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Mechanism of Action of 1,25-Dihydroxyvitamin D3 on Intestinal Calcium Absorption and Renal Calcium Transport

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Vitamin D

Part of the book series: Nutrition and Health ((NH))

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Abstract

In mammals the plasma calcium concentration under normal conditions is maintained at 2.5 mM or 10 mg/dL. Ionized calcium represents approx 45% of the total plasma calcium. An equal portion of the plasma calcium is bound to proteins, and approx 10% is complexed with small anions. Vitamin D is a principle factor that maintains the plasma calcium level within the normal range, and the intestine, kidney, and bone are the three target organs of vitamin D action primarily responsible for maintaining calcium homeostasis (1). This chapter focuses on how vitamin D [and specifically the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)] acts at times of increased calcium demand to increase the efficiency of calcium absorption from the intestine and to enhance the tubular reabsorption of calcium from the kidney.

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Authors
  1. Mihali Raval-Pandya
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  2. Angela R. Porta
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  3. Sylvia Christakos
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Editors and Affiliations

  1. Boston University Medical Center, Boston, MA, USA

    Michael F. Holick PhD, MD

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Raval-Pandya, M., Porta, A.R., Christakos, S. (1999). Mechanism of Action of 1,25-Dihydroxyvitamin D3 on Intestinal Calcium Absorption and Renal Calcium Transport. In: Holick, M.F. (eds) Vitamin D. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2861-3_10

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  • DOI: https://doi.org/10.1007/978-1-4757-2861-3_10

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-2863-7

  • Online ISBN: 978-1-4757-2861-3

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