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The Dopamine Receptors pp 383–424Cite as

Regulation of Dopamine Receptor Function and Expression

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Part of the book series: The Receptors ((REC))

Abstract

Regulation of receptor responsiveness by neurotransmitters and hormones is a well-recognized phenomenon that has been demonstrated for most receptor systems (1). Such regulation can involve desensitization, the tendency of receptor responsiveness to wane over time despite the presence of a stimulus of constant intensity; or amplification, in which the receptor system becomes supersensitive to agonist stimulation. Regulation of receptor function and expression may limit the efficacy of numerous pharmacological agents, and thus the investigation of such phenomena may have a major impact in refining and developing therapeutic agents.

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Authors
  1. David R. Sibley
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  2. Kim A. Neve
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Editors and Affiliations

  1. Department of Behavioral Neuroscience, Oregon Health Sciences University and VA Medical Center, Portland, OR, USA

    Kim A. Neve

  2. Department of Genetics, Harvard Medical School, McLean Hospital, Belmont, MA, USA

    Rachael L. Neve

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© 1997 Springer Science+Business Media New York

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Sibley, D.R., Neve, K.A. (1997). Regulation of Dopamine Receptor Function and Expression. In: Neve, K.A., Neve, R.L. (eds) The Dopamine Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2635-0_13

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  • DOI: https://doi.org/10.1007/978-1-4757-2635-0_13

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-2637-4

  • Online ISBN: 978-1-4757-2635-0

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