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The GABA Receptors pp 271–296Cite as

Chemistry of GABAB Modulators

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Part of the book series: The Receptors ((REC))

Abstract

An important step toward understanding the diverse roles of the ubiquitous inhibitory neurotransmitter g-aminobutyric acid (GABA) was Bowery’s discovery that baclofen 1 (Fig. 1) stereospecifically decreases neurotransmitter release in the mammalian central nervous system (CNS) by action at a novel GABA receptor, an effect that was not blocked by bicuculline or other GABA antagonists (Bowery et al., 1980; Hill and Bowery, 1981).

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Authors
  1. Wolfgang Froestl
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  2. Stuart J. Mickel
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Editors and Affiliations

  1. Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical School, Kansas City, KS, USA

    S. J. Enna

  2. Department of Pharmacology, The Medical School Edgbaston, University of Birmingham, UK

    Norman G. Bowery

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© 1997 Springer Science+Business Media New York

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Froestl, W., Mickel, S.J. (1997). Chemistry of GABAB Modulators. In: Enna, S.J., Bowery, N.G. (eds) The GABA Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2597-1_10

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  • DOI: https://doi.org/10.1007/978-1-4757-2597-1_10

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-2599-5

  • Online ISBN: 978-1-4757-2597-1

  • eBook Packages: Springer Book Archive

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