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Thyroid Disease in Infancy, Childhood, and Adolescence

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Diseases of the Thyroid

Part of the book series: Contemporary Endocrinology ((COE,volume 2))

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Abstract

Unlike in the adult, thyroid disease in the child is associated with important effects on growth and development. Although thyroid disorders often are subtle in presentation, the deleterious consequences of late or inappropriate diagnosis and treatment may be irreversible. In general, severe congenital abnormalities present in infancy whereas less severe defects or acquired abnormalities, particularly autoimmune thyroid disease, develop later in childhood and adolescence. In the newborn infant, thyroid disease may result not only from an abnormality in the child but as a result of the transplacental passage from the mother of factors that affect the fetal thyroid gland.

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References

  1. Fisher DA, Dussault JH, Foley TP, et al. Screening for congenital hypothyroidism: Results of screening one million North American infants. J Pediatr 1979; 94: 700–705.

    Article  PubMed  CAS  Google Scholar 

  2. Fort P, Lifshitz F, Bellisario R, et al. Abnormalities of thyroid function in infants with Down syndrome. J Pediatr 1984; 104: 545–549.

    Article  PubMed  CAS  Google Scholar 

  3. Dussault JH, Letarte J, Guyda H, Laberge C. Lack of influence of thyroid antibodies on thyroid function in the newborn infant and on a mass screening program for congenital hypothyroidism. J Pediatr 1980; 96: 385–389.

    Article  PubMed  CAS  Google Scholar 

  4. van der Gaag RD, Drexhage HA, Dussault JH. Role of maternal immunoglobulins blocking TSH-induced thyroid growth in sporadic forms of congenital hypothyroidism. Lancet 1985; 1: 246–250.

    Article  PubMed  Google Scholar 

  5. Bogner U, Gruters A, Sigle B, Helge H, Schleusener H. Cytotoxic antibodies in congenital hypothyroidism. J Clin Endocrinol Metab 1989; 68: 671–675.

    Article  PubMed  CAS  Google Scholar 

  6. Brown RS, Keating P, Mitchell E. Maternal thyroid-blocking immunoglobulins in congenital hypothyroidism. J Clin Endocrinol Metab 1990; 70: 1341–1346.

    Article  PubMed  CAS  Google Scholar 

  7. Lever EG, Medeiros-Neto GA, DeGroot LJ. Inherited disorders of thyroid metabolism. Endocr Rev 1983; 4: 213–239.

    Article  PubMed  CAS  Google Scholar 

  8. Bikker H, den Hartog MT, Baas F, Gons MH, Vulsma T, de Vijlder JJ. J Clin Endocrinol Metab 1994; 79: 248–252.

    Article  PubMed  CAS  Google Scholar 

  9. Medeiros-Neto G, Targovnik MH, Vassart G. Defective thyroglobulin synthesis and secretion causing goiter and hypothyroidism. Endocr Rev 1994; 14: 165–183.

    Google Scholar 

  10. Targovnik HM, Vono J, Billerbeck AE, et al. A 138-nucleotide deletion in the thyroglobulin-ribonucleic acid messenger in a congenital goiter with defective thyroglobulin synthesis. 1995; 80: 3356–3360.

    CAS  Google Scholar 

  11. Brown RS, Bhatia V, Hayes E. An apparent cluster of congenital hypopituitarism in central Massachusetts: Magnetic resonance imaging and hormonal studies. J Clin Endocrinol Metab 1991; 72: 12–18.

    Article  PubMed  CAS  Google Scholar 

  12. Wit JM, Drayer NM, Jansen M, et al. Total deficiency of growth hormone and prolactin, and partial deficiency of thyroid stimulating hormone in two Dutch families: a new variant of hereditary pituitary deficiency. Horm Res 1989; 32: 170–177.

    Article  PubMed  CAS  Google Scholar 

  13. Weiss RE, Balzano S, Scherberg NH, Refetoff S. Neonatal detection of generalized resistance to thyroid hormone. JAMA 1990; 264: 2245–2250.

    Article  PubMed  CAS  Google Scholar 

  14. McDermott MT, Ridgway EC. Thyroid hormone resistance syndromes. Am J Med 1993; 94: 424–432.

    Article  PubMed  CAS  Google Scholar 

  15. Castaing H, Fournet JP, Leger FA, et al. Thyroid du nouveau-ne et surcharge en iode apres la naissance. Arch Franc Pediat 1979; 56: 356–368.

    Google Scholar 

  16. Smerdely P, Lim A, Boyages SC, et al. Topical iodine-containing antiseptics and neonatal hypothyroidism in very-low-birthweight infants. Lancet 1989; 2: 661–664.

    Article  PubMed  CAS  Google Scholar 

  17. Delange F. Iodine nutrition and congenital hypothyroidism. In: Delange F, Fisher DA, Glinoer D, eds. Research in Congenital Hypothyroidism. New York, Plenum Press, 1989, pp. 173–185.

    Chapter  Google Scholar 

  18. Brown RS, Bellisario RL, Botero D, et al. Incidence of transient congenital hypothyroidism due to maternal thyrotropin receptor-blocking antibodies in over one million babies. J Clin Endocrinol Metab 1996; 81: 1147–1151.

    Article  PubMed  CAS  Google Scholar 

  19. a.Brown RS. Autoimmune thyroid disease in pregnant women and their offspring. Endocrine Practice 1996; 2: 53–61.

    Google Scholar 

  20. Matsuura N, Konishi J, and the transient hypothyroidism study group in Japan. Endocrinol Japon 1990; 37: 369–379.

    Article  CAS  Google Scholar 

  21. Czernichow P, Vandalem JL, Hennen G. Transient neonatal hyperthyrotropinemia: A factitious syndrome due to the presence of heterophilic antibodies in the plasma of infants and their mothers. J Clin Endocrinol Metab 1981; 53: 387–393.

    Article  PubMed  CAS  Google Scholar 

  22. Miki K, Nose O, Miyai K, Yabuuchi H, Haradi T. Transient infantile hyperthyrotropinemia. Arch Dis Child 1989; 64: 177–182.

    Article  Google Scholar 

  23. Fisher DA. Clinical Review 19: Management of congenital hypothyroidism. J Clin Endocrinol Metab 1991; 72: 523–529.

    Article  PubMed  CAS  Google Scholar 

  24. Reuss ML, Paneth N, Pinto-Martin JA, Lorenz JM, Susser J. The relation of transient hypothyroxinemia in preterm infants to neurologic development at two years of age. N Engl J Med 1996; 334: 821–827.

    Article  PubMed  CAS  Google Scholar 

  25. LaFranchi SH, Hanna CE, Krainz PL, Skeels MR, Miyahira RS, Sesser DE. Screening for congenital hypothyroidism with specimen collection at two time periods: Results of the northwest regional screening program. Pediatrics 1985; 76: 734–740.

    PubMed  CAS  Google Scholar 

  26. Mitchell ML, Pitischman N, Larsen PR, Klein RZ. Screening very-low-birthweight infants for congenital hypothyroidism. Lancet 1994; 343: 60–61.

    Article  PubMed  CAS  Google Scholar 

  27. LaFranchi S, Dussault JH, Fisher DA, et al. American Academy of Pediatrics American Thyroid Association Newborn screening for congenital hypothyroidism: Recommended guidelines. Pediatrics 1993; 91: 1203–1209.

    Google Scholar 

  28. New England Congenital Hypothyroidism Collaborative. Effects of neonatal hypothyroidism: prevention of mental retardation by treatment before clinical manifestations. Lancet 1981; 2: 1095–1098.

    Google Scholar 

  29. Dubuis J-M, Glorieux J, Richer F, Deal CL, Dussault JH, Van Vliet G. Outcome of severe congenital hypothyroidism: closing the developmental gap with early high dose levothyroxine treatment. J Clin Endocrinol Metab 1996; 81: 222–227.

    Article  PubMed  CAS  Google Scholar 

  30. Chorazy PA, Himelhoch S, Hopwood NJ, Greger NC, Postellon DC. Persistent hypothyroidism in an infant receiving a soy formula: Case report and review of the literature. Pediatrics 1995; 96: 148–150.

    PubMed  CAS  Google Scholar 

  31. Zakarija M, McKenzie JM. Pregnancy-associated changes in the thyroid-stimulating antibody of Graves’ disease and the relationship to neonatal hyperthyroidism. J Clin Endocrinol Metab 1983; 57: 1036–1040.

    Article  PubMed  CAS  Google Scholar 

  32. Burrow GN. The management of thyrotoxicosis in pregnancy. N Engl J Med 1985; 313: 562–565.

    Article  PubMed  CAS  Google Scholar 

  33. Fort P, Lifshitz F, Pugliese M, Klein I. Neonatal thyroid disease: Differential expression in three successive offspring.J Clin Endocrinol Metab 1988; 66: 645–647.

    Article  CAS  Google Scholar 

  34. Daneman D, Howard NH. Neonatal thyrotoxicosis: Intellectual impairment and craniosynostosis in later years. J Pediatr 1980; 97: 257–259.

    Article  PubMed  CAS  Google Scholar 

  35. Fisher DA. Neonatal thyroid disease in the offspring of women with autoimmune thyroid disease. Thyroid Today 1986; 9 (4): 1–7.

    Google Scholar 

  36. Zakarija M, McKenzie JM. Immunoglobulin G inhibitor of thyroid-stimulating antibody is a cause of delay in the onset of neonatal Graves’ disease. J Clin Invest 1983; 72: 1352–1356.

    Article  PubMed  CAS  Google Scholar 

  37. Tamaki H, Amino N, Takeoka K, et al. Prediction of later development of thyrotoxicosis or central hypothyroidism from the cord serum thyroid-stimulating hormone level in neonates born to mothers with Graves’ disease. J Pediatr 1989; 115: 318–321.

    Article  PubMed  CAS  Google Scholar 

  38. Karpman BA, Rapoport B, Filetti S, Fisher DA. Treatment of neonatal hyperthyroidism due to Graves’ disease with sodium ipodate. J Clin Endocrinol Metab 1987; 64: 119–123.

    Article  PubMed  CAS  Google Scholar 

  39. Hollingsworth DR, Mabry CC. Congenital Graves’ disease: Four familial cases with long-term follow-up and perspective. Am J Dis Child 1976; 130: 148–155.

    PubMed  CAS  Google Scholar 

  40. Kopp P, van Sande J, Parma J, et al. Brief report: Congenital hyperthyroidism caused by a mutation in the thyrotropin-receptor gene. N Engl J Med 1995; 332: 150–154.

    Article  PubMed  CAS  Google Scholar 

  41. Foley TP, Abbassi V, Copeland KC, Draznin MB. Brief report: Hypothyroidism caused by chronic autoimmune thyroiditis in very young infants. N Engl J Med 1994; 330: 466–468.

    Article  PubMed  Google Scholar 

  42. Gilani BB, MacGillivray MH, Voorhees ML, et al. Thyroid hormone abnormalities in diagnosis of insulin-dependent diabetes mellitus in children. J Pediatr 1984; 105: 218–222.

    Article  PubMed  CAS  Google Scholar 

  43. Neufeld M, MacLaren N, Blizzard R. Autoimmune polyglandular syndromes. Pediatr Ann 1980; 9: 154–162.

    PubMed  CAS  Google Scholar 

  44. LaFranchi S. Thyroiditis and acquired hypothyroidism. Pediatr Ann 1992; 21: 29–39.

    PubMed  CAS  Google Scholar 

  45. Leznoff A, Josse RG, Denburg J, Dolovich J. Association of chronic urticaria and angioedema with thyroid autoimmunity. Arch Dermatol 1983; 119: 636–640.

    Article  PubMed  CAS  Google Scholar 

  46. O’Regan S, Fong JSC, Kaplan BS, de Chadarivian J-P, Lapointe N, Drummond KN. Thyroid antigen-antibody nephritis. Clin Immunol Immunopathol 1976; 6: 341–346.

    Article  PubMed  Google Scholar 

  47. Matsuura N, Konishi J, Yuri K, et al. Comparison of atrophic and goitrous autoimmune thyroiditis in children: clinical, laboratory and TSH-receptor antibody studies. Eur J Pediatr 1990; 149: 529–533.

    Article  PubMed  CAS  Google Scholar 

  48. Takasu N, Yamada T, Takasu K, et al. Disappearance of thyrotropin-blocking antibodies and spontaneous recovery from hypothyroidism in autoimmune thyroiditis. N Engl J Med 1992; 326: 513–518.

    Article  PubMed  CAS  Google Scholar 

  49. Brown RS. Editorial: Immunoglobulins affecting thyroid growth: A continuing controversy. J Clin Endocrinol Metab 1995; 80: 1506–1508.

    PubMed  CAS  Google Scholar 

  50. Rallison ML, Dobyns BM, Keating FR, Rall JE, Tyler FH. Occurrence and natural history of chronic lymphocytic thyroiditis in childhood. J Pediatr 1975; 86: 675–682.

    Article  PubMed  CAS  Google Scholar 

  51. Maenpaa J, Raatikka M, Rasanen J, Taskinen E, Wager O. Natural course of juvenile autoimmune thyroiditis. J Pediatr 1985; 107: 898–904.

    Article  PubMed  CAS  Google Scholar 

  52. Surks MI, Sievert R. Drugs and thyroid function. N Engl J Med 1995; 333: 1688–1694.

    Article  PubMed  CAS  Google Scholar 

  53. Barsano CP. Other forms of primary hypothyroidism. In: Braverman LE, Utiger RD, eds. Werner and Ingbar’s The Thyroid: A Fundamental and Clinical Text, 6th ed. Lippincott, Philadelphia, 1991, pp. 956–967.

    Google Scholar 

  54. Hauser P, Zametkin AJ, Martinez P, et al. Attention deficit-hyperactivity disorder in people with generalized resistance to thyroid hormone. N Engl J Med 1993; 328: 997–1001.

    Article  PubMed  CAS  Google Scholar 

  55. Alos N, Huot C, Lambert R, Van Vliet G. Thyroid scintigraphy in children and adolescents with Hashimoto disease. J Pediatr 1995; 127: 951–953.

    Article  PubMed  CAS  Google Scholar 

  56. Rovet JF, Daneman D, Bailey JD. Psychological and psychoeducational consequences of thyroxine therapy for juvenile acquired hypothyroidism. J Pediatr 1993; 122: 543–549.

    Article  PubMed  CAS  Google Scholar 

  57. Van Dop C, Conte FA, Koch TK, Clark SJ, Wilson-Davis SL, Grumbach M M. Pseudotumor cerebri associated with initiation of levothyroxine therapy for juvenile hypothyroidism. N Engl J Med 1983; 308: 1076–1080.

    Article  PubMed  Google Scholar 

  58. van der Gaag RD, Drexhage HA, Wiersinga WM, et al. Further studies in thyroid growthimmunoglobulins in euthyroid non-endemic goiter. J Clin Endocrinol Metab 1985; 60: 972–979.

    Article  PubMed  Google Scholar 

  59. Rother KI, Zimmerman D, Schwenk WF. Effect of thyroid hormone treatment on thyromegaly in children and adolescents with Hashimoto disease. J Clin Endocrinol Metab 1994; 124: 599–601.

    CAS  Google Scholar 

  60. Foley TP. Thyrotoxicosis in childhood. Pediatr Ann 1992; 21: 43–49.

    PubMed  Google Scholar 

  61. Tahara K, Ban T, Minegishi T, Kohn L. Immunoglobulin from Graves’ disease patients interact with different sites on TSH receptor/LH-CG chimeras than either TSH or immunoglobulins from idiopathic myxoedema. Biochem Biophys Res Commun 1991; 179: 70–77.

    Article  PubMed  CAS  Google Scholar 

  62. Bellur S, Tahara K, Saji M, Grollman EF, Kohn LD. Repeatedly passed FRTL-5 rat thyroid cells can develop insulin and insulin-like growth factor-l-sensitive cyclooxygenase and prostaglandin E, isomerase-like activities together with altered basal and thyrotropin-responsive thymidine incorporation into DNA. J Clin Endocrinol Metab 1990; 127: 1526–1540.

    CAS  Google Scholar 

  63. Cohen RJ, Landaw EM, Kaplan SA, Lippe BM. Remission rates of children and adolescents with thyrotoxicosis treated with antithyroid drugs. Pediatrics 1980; 65: 550–555.

    Google Scholar 

  64. Hashizume K, Ichikawa K, Sakurai A, et al. Administration of thyroxine in treated Graves’ disease. Effects on the level of antibodies to thyroid-stimulating hormone receptors and on the risk of recurrence of hyperthyroidism. N Engl J Med 1991; 324: 947–953.

    Article  PubMed  CAS  Google Scholar 

  65. McIver B, Rae P, Beckett G, Wilkinson E, Gold A, Toft A. Lack of effect of thyroxine in patients with Graves’ hyperthyroidism who are treated with an antithyroid drug. N Engl J Med 1996; 334: 220–224.

    Article  PubMed  CAS  Google Scholar 

  66. Levy WJ, Schumacher OP, Gupta M. Treatment of childhood Graves’ disease. Cleve Clin J Med 1988; 55: 373–382.

    PubMed  CAS  Google Scholar 

  67. Hung W, Anderson KD, Chandra RS, et al. Solitary thyroid nodules in 71 children and adolescents. J Pediatr Surg 1992; 27: 1407–1409.

    Article  PubMed  CAS  Google Scholar 

  68. Kazakov KS, Demidchik EP, Astakhova LN. Thyroid cancer after Chernobyl. Nature 1992; 359: 21.

    Article  PubMed  CAS  Google Scholar 

  69. Hung W. Well-differentiated thyroid carcinomas in children and adolescents: A review. The Endocrinologist 1994; 4: 117–126.

    Article  Google Scholar 

  70. Gorlin JB, Sallan SE. Thyroid cancer in childhood. Endocrinol Metab Clin North Am 1990; 19: 649–662.

    PubMed  CAS  Google Scholar 

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Authors
  1. Rosalind S. Brown MD, CM, FRCP(C)
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Editors and Affiliations

  1. Division of Endocrinology and Metabolism, University of Massachusetts Medical Center, Worcester, Massachusetts, USA

    Lewis E. Braverman MD

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Brown, R.S. (1997). Thyroid Disease in Infancy, Childhood, and Adolescence. In: Braverman, L.E. (eds) Diseases of the Thyroid. Contemporary Endocrinology, vol 2. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2594-0_6

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  • DOI: https://doi.org/10.1007/978-1-4757-2594-0_6

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-2596-4

  • Online ISBN: 978-1-4757-2594-0

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