Abstract
The basic idea of gene transfer arose in the late 1950s, after the discovery that viruses have an intrinsic capability to transfer their genetic material into infected cells. By this mechanism, some viruses, such as retroviruses, are able to establish life-long expression of a foreign gene in cells of diverse origins. Unfortunately, it is not possible to infect nondividing cells with retroviruses. This has led to the development of nontoxic mutants of other viruses, such as adenovirus and herpesvirus, to infect other cell types, such as neurons, which are refractory to infection by retroviruses.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Further Reading
Friedmann, T. (1994), Gene therapy for neurological disorders. Trends Genet, 10, 210–214.
Glorioso, J. C., DeLuca, N. A., and Fink, D. J. (1995), Development and application of herpes simplex virus vectors for human gene therapy. Annu. Rev. Microbiol. 49, 675–710.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Dyer, A.P., Tufaro, F. (1997). Herpes Simplex Virus Vectors for Gene Therapy of the Nervous System. In: Fedoroff, S., Richardson, A. (eds) Protocols for Neural Cell Culture. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2586-5_13
Download citation
DOI: https://doi.org/10.1007/978-1-4757-2586-5_13
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-0-89603-454-9
Online ISBN: 978-1-4757-2586-5
eBook Packages: Springer Book Archive