Abstract
The catalytic cycle of cytochrome P450 (see Chapters 3 and 8) traverses three steps that are particularly vulnerable to inhibition: (1) the binding of substrates, (2) the binding of molecular oxygen subsequent to the first electron transfer, and (3) the catalytic step in which the substrate is actually oxidized. This chapter focuses on inhibitors that act at one of these three steps. Inhibitors that act at other steps in the catalytic cycle, such as agents that interfere with the electron supply to the hemoprotein by accepting electrons directly from cytochrome P450 reductase,1–3 are not discussed here.
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de Montellano, P.R.O., Correia, M.A. (1995). Inhibition of Cytochrome P450 Enzymes. In: de Montellano, P.R.O. (eds) Cytochrome P450. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2391-5_9
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