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Anatomical Distribution of Metabotropic Glutamate Receptors in Mammalian Brain

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The Metabotropic Glutamate Receptors

Part of the book series: The Receptors ((REC))

Abstract

Metabotropic glutamate receptors (mGluRs) are linked to second messengers through G-proteins and play an important role in normal neuronal functions, as well as plasticity and response to injury. Until recently, it has not been possible to examine the detailed localization of mGluRs in mammalian brain because of the lack of specific agonists and antagonists amenable to ligand binding studies and the lack of cloned cDNA sequences for the development of specific in situ hybridization probes or antibodies for immunocytochemistry. In the past few years, many of these reagents have become available, yielding data from several avenues that have indicated marked regional heterogeneity in the distributions of mGluR subtypes. In this chapter, we will review the regional expression of the five mGluR genes that have been most thoroughly characterized, the second-messenger systems associated with these receptors, and the autoradiographic binding studies of pharmacological subtypes.

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Authors
  1. Claudia M. Testa
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  2. Maria Vincenza Catania
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  3. Anne B. Young
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Editors and Affiliations

  1. Department of Pharmacology, Emory University, Atlanta, GA, USA

    P. Jeffrey Conn

  2. Zeneca Pharmaceuticals Group, Wilmington, DE, USA

    Jitendra Patel

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Testa, C.M., Catania, M.V., Young, A.B. (1994). Anatomical Distribution of Metabotropic Glutamate Receptors in Mammalian Brain. In: Conn, P.J., Patel, J. (eds) The Metabotropic Glutamate Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2298-7_4

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  • DOI: https://doi.org/10.1007/978-1-4757-2298-7_4

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-006-9

  • Online ISBN: 978-1-4757-2298-7

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