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Protein Kinase C and Contraction of Vascular Smooth Muscle

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The Resistance Arteries

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 26))

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Abstract

Protein Kinase C (PKC) is a Ca++ and phosphatidylserine (PS) dependent serine/threonine kinase that functions as a ubiquitous cellular mediator of signal transduction initiated by a variety of agonists (1).

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References

  1. Nishizuka, Y. Intracellular signalling by hydrolysis of phospholipids and activation of PKC. Science 258: 607–613, 1992

    Article  PubMed  CAS  Google Scholar 

  2. Pears, C.J, and Parker, P.J. Domain interactions in protein kinase C. J.Cell Science 100: 683–686, 1991

    PubMed  CAS  Google Scholar 

  3. Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361: 315–325, 1993

    Article  PubMed  CAS  Google Scholar 

  4. Crabos, M., Fabbro, D., Stabel, S, and Erne P. Effect of phorbol ester, thrombin and vasopressin in translocation of three distinct protein kinase C isoforms in human platelets. Biochem J. 288: 891–896, 1992

    PubMed  CAS  Google Scholar 

  5. Mochly-Rosen, D., Henrich, C., Cheever, L., Khmer, H., and Simpson, P. A protein kinase C isozyme is translocated to cytoskeletal elements on activation. Cell Reg. 1: 693–706, 1990

    CAS  Google Scholar 

  6. Kiley, S., Schaap, D., Parker, P., Hsieh, L-L, and Jaken, S. Protein kinase C heterogeneity in GH4C1 rat pituitary cells. J.Biol.Chem. 265: 15704–15712, 1990

    PubMed  CAS  Google Scholar 

  7. Kiley, S., Parker, P., Fabbro, D., and Jaken, S. Differential regulation of protein kinase C isozymes by Thyrotropin releasing hormone in GH4C, cells. J.Biol Chem. 266: 23761–23768, 1991

    PubMed  CAS  Google Scholar 

  8. Griendling, K.K., Rittenhouse, S.E., Brock, T.A., Ekstein, L.S., Gimbrone, M.A. JR., Alexander, R.W. Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells. J.Biol.Chem. 261: 5901–5906, 1986

    PubMed  CAS  Google Scholar 

  9. Ohanian, J., Izzard AS, Littlewood M, Heagerty AM. Regulation of diacylglycerol metabolisms by vasoconstrictor hormones in intact small arteries. Circ. Res. 72: 1163–1171, 1993

    Article  PubMed  CAS  Google Scholar 

  10. Danthuluri, NR and Deth, R.C. Phorbol-ester-induced contractions of arterial smooth muscle and inhibition of aadrenergic response. Biochim Biophys Res Commun. 125: 1103–1109, 1984

    Article  CAS  Google Scholar 

  11. Park, S., and Rasmussen, H. Carbachol-induced protein phosphorylation changes in bovine tracheal smooth muscle. J.Biol.Chem. 261: 15734–15739, 1986

    PubMed  CAS  Google Scholar 

  12. Andrea, J.E and Walsh, M.P. Protein kinase C of smooth muscle. Hypertens. 20: 585–595, 1992

    Article  CAS  Google Scholar 

  13. Shaw, L, White, S., Ohanian, J., Parker, P.J., Ohanian, V and Heagerty, A.M. Down regulation of protein kinase C does not markedly alter the contractile response to agonists in small arteries. J.Vasc. Res. 31, S1: 46, 1994

    Google Scholar 

  14. Collins, E.M., Walsh, M.P., and Morgan, K.G. Contraction of single vascular smooth muscle cells by phenylephrine. Am.J. Physiol 262: H754 - H762, 1992

    PubMed  CAS  Google Scholar 

  15. Ohanian, J., Ollerenshaw J.D., Collins, P., and Heagerty, AM. Agonist-induced production of 1,2-diacylglycerol and phosphatidic acid in intact resistance arteries. J. Biol. Chem. 256: 8921–8928, 1990

    Google Scholar 

  16. Exton, J. Signalling through phosphatidylcholine breakdown. J.Biol. Chem. 265: 1–4, 1990

    PubMed  CAS  Google Scholar 

  17. Jones, A.W., Shivendra, D., Shukla, and Geisbuhler, B.B. Stimulation of phospholipase D activity and phosphatidic acid production by norepinephrine in rat aorta. Am. J. Physiol, 264: C609 - C616, 1993

    CAS  Google Scholar 

  18. Liu, Y., Geisbuhler, B., and Jones, A.W. Activation of multiple mechanisms including phospholipase D by endothelin-1 in rat aorta. Am. J. Physiol. 262: C941 - C949, 1992

    CAS  Google Scholar 

  19. Gu, H., Trajkovic, S., and LaBelle, E.F. Norepinephrineinduced phsophatidylcholine hydrolysis by phospholipases D and C in rat tail artery. Am.J.Physiol. 262: C1376 - C1383, 1992

    PubMed  CAS  Google Scholar 

  20. Ward, D., Ohanian, J., Ohanian, V., and Heagerty, A.M. Stimulation of phospholipase D hydrolysis of phosphatidylcholine by noradrenaline in rat small arteries. J.Vasc.Res. 31, Si: 54, 1994

    Google Scholar 

  21. Jackowski, S., and Rock, C.O. Stimulation of phosphatidylinos itol 4,5 bisphosphate phospholipase C activity by phosphatidic acid. Arch. Biochem. Biophys. 268: 516 - 524, 1989

    Article  CAS  Google Scholar 

  22. Salmon, D.M and Honeyman, T.W. Proposed mechanism of cholinergic action in smooth muscle. Nature, 284: 344–347, 1980

    Article  PubMed  CAS  Google Scholar 

  23. Thibonnier, M, Bayer, A.L., Simonson, M.S., and Kester, M. Multiple signalling pathways of V,-vascular vasopressin receptors of A7rs cells. Endocrinology, 129: 2845–2856, 1991

    Article  PubMed  CAS  Google Scholar 

  24. Cadena, D.L, and Gill, G.N. Receptor tyrosine kinases. FASEB J. 6: 2332–2337, 1992

    PubMed  CAS  Google Scholar 

  25. Hughes, A.D. The action of platelet derived growth factor on tone and intracellular Cat+ in isolated rabbit ear artery. J. V asc. Res. 31, S 1: 17, 1994

    Google Scholar 

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© 1994 Springer Science+Business Media New York

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Ohanian, J., Statham, F., Shaw, L., White, S., Heagerty, A.M., Ohanian, V. (1994). Protein Kinase C and Contraction of Vascular Smooth Muscle. In: Halpern, W., Bevan, J., Brayden, J., Dustan, H., Nelson, M., Osol, G. (eds) The Resistance Arteries. Experimental Biology and Medicine, vol 26. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2296-3_6

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  • DOI: https://doi.org/10.1007/978-1-4757-2296-3_6

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-008-3

  • Online ISBN: 978-1-4757-2296-3

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