Abstract
The concept that inositol phospholipid hydrolysis is a very early event and is responsible for transducing the effect of hormone-receptor stimulation to the cell interior is now widely accepted. The activation of these specific receptors stimulates phospholipase C which degrades membrane-bound phosphatidylinositol 4,5-bisphosphate to produce two second messengers: inositol 1,4,5-trisphosphate, which can liberate Ca2+ from intracellular stores, and 1,2-diacylglycerol, which activates protein kinase C. The membrane-bound transducer that relates the message from the receptor to the phospholipase C seems to be a specific GTP-binding protein, that is referred to as Gp, where p stands for phosphoinositide.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
M.J. Berridge, Inositol trisphosphate and diacylglycerol: two interacting secondary messengers. Annu. Rev. Biochem., 56: 159 - 193 (1987).
Y. Nishizuka, The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature, 308: 693 - 698 (1984).
S. Cockcroft and B.D. Gomperts, Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase. Nature, 314: 534 - 536 (1985).
I. Litosch and J.N. Fain, Regulation of phosphoinositide breakdown by guanine nucleotides. Life Sci. 39: 187 - 194 (1986).
E.G. Lapetina, Inositide-dependent and independent mechanisms in platelet activation. In: Phosphoinositides and Receptor Mechanisms, edited by J.W. Putney, Jr., p. 271. Alan R. Liss, New York (1986).
E.G. Lapetina, Regulation of arachidonic acid production: Role of phospholipases C and A2, Trends in Pharmacol. Sci. 3: 115 - 118, (1982).
M.F. Crouch and E.G. Lapetina, No direct correlation between Ca2+ mobilization and dissociation of Gi during phospholipase A2 activation. Biochem. Biophys. Res. Commun. 153: 21 - 30 (1988).
M.M. Billah and E.G. Lapetina, Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets. J. Biol. Chem., 257: 12705 - 12708 (1982).
S. Rittenhouse-Simmons, Production of diglyceride from phosphatidylinositol in activated human platelets. J. Clin. Invest., 63: 580 - 587 (1979).
P.W. Majerus, D.B. Wilson, T.M. Connolly, T.E. Bross and E.J. Neufeld, Phosphoinositide turnover provides a link in stimulus-response coupling. TIBS. 10: 168 - 171 (1985).
H. Streb, R.F. Irvine, M.J. Berridge and I. Schulz, Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature, 306: 67 - 69 (1983).
L. Molina y Vedia and E.G. Lapetina, Phorbol 12,13-dibutyrate and 1-oleyl, 2-acetyl-diacylglycerol stimulate inositol trisphosphate dephosphorylation in human platelets. J. Biol. Chem. 261: 10493 - 10495 (1986).
L. Molina y Vedia and E.G. Lapetina, Subcellular localization of the enzymes that dephosphorylate myoinositol phosphates in human platelets. Biochem. J. 255: 795 - 800 (1988).
T.M. Connolly, T.E. Bross and P.W. Majerus, Isolation of a phosphomonoesterase from human platelets that specifically hydrolyses the 5-phosphate of inositol 1,4,5-trisphosphate. J. Biol. Chem., 260: 7868 - 7874 (1985).
R.F. Irvine, A.J. Letcher, J.P. Heslop and M.J. Berridge,The inositol tris/tetrakisphosphate pathway: demonstration of Ins (1,4,5) P3 3-kinase activity in animal tissues. Nature, 320: 631 - 634 (1986).
T.J. Giden, M. Comte, J.A. Cox and C.B. Wollheim, Calcium calmodulin stimulates inositol 1,4,5-trisphosphate kinase activity from insulin-secreting RINm 5F cells. J. Biol. Chem., 262: 9437 - 9440 (1987).
A.E. Traynor-Kaplan, A.L. Harris, B.L. Thompson, P. Taylor and L.A. Sklar, An inositol tetrakisphosphate-containing phospholipid in activated neutrophils. Nature 334:353 - 356 (1988).
M. Whitman, C.P. Downes, M. Keeler, T. Keller and L. Cantley, Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 332:644 - 646 (1988).
T. Balla, G. Guillemette, A.J. Baukal and K.J. Catt, Metabolism of inositol 1,3,4-trisphosphate to a new tetrakisphosphate isomer in angiotensin-stimulated adrenal glomerulosa cells. J. Biol. Chem. 262: 9952 - 9955 (1987).
M.F. Crouch and E.G. Lapetina, A role for Gi in control of thrombin receptor-phospholipase C coupling in human platelets. J. Biol Chem., 263: 3363 - 3371 (1988).
E.G. Lapetina, J.C. Lacal, B.R. Reep and L. Molina y Vedia, A ras-related protein is phosphorylated and translocated by agonists that increase cyclic AMP levels in human platelets, Proc. Natl. Acad. Sei. U.S.A. 86: 3131 - 3134 (1989).
S.P. Watson, R.T. McConnell and E.G. Lapetina, The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin. J. Biol. Chem., 259: 13199 - 13203 (1984).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer Science+Business Media New York
About this chapter
Cite this chapter
Lapetina, E.G. (1989). The Inositide and Arachidonic Acid Signal System. In: Ekholm, R., Kohn, L.D., Wollman, S.H. (eds) Control of the Thyroid Gland. Advances in Experimental Medicine and Biology, vol 261. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2058-7_11
Download citation
DOI: https://doi.org/10.1007/978-1-4757-2058-7_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-2060-0
Online ISBN: 978-1-4757-2058-7
eBook Packages: Springer Book Archive