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Dietary w-3 and w-6 Fatty Acids in Cancer

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Book cover Dietary ω3 and ω6 Fatty Acids

Abstract

The evidence that dietary fat relates to cancers of the breast and colon, and probably other types of cancer, has been built on descriptive and metabolic epidemiology, correlation studies, migrant studies, case-control studies, and experimental animal studies1. This overall evidence has led to recommendations that dietary fat intake be reduced to decrease the risk of developing certain types of cancer.2,3

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References

  1. E. L. Wynder, Amount and type of fat/fiber in nutritional carcinogenesis, Prev. Med. 16: 451 (1987).

    Article  PubMed  CAS  Google Scholar 

  2. B. Armstrong and R. Doll, Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices, Int. J. Cancer 15: 617 (1975).

    Article  PubMed  CAS  Google Scholar 

  3. National Academy of Sciences, Committee on Diet, Nutrition and Cancer, Diet, Nutrition and Cancer, Natl. Acad. Press, Washington, D.C. (1982).

    Google Scholar 

  4. M. Kurihara, K. Aoki, S. Tominaga, eds., Cancer Mortality Statistics in the World, University of Nogoya Press, Nagoya, Japan (1984).

    Google Scholar 

  5. L. A. Cohen, D. O. Thompson, K. Choi, R. A. Karnali, and D. P. Rose, Dietary fat and mammary cancer. II. Modulation of serum and tumor lipid composition and tumor prostaglandins by different dietary fats: association with tumor incidence patterns, J. Natl. Cancer Inst. 77: 43 (1986).

    PubMed  CAS  Google Scholar 

  6. T. Hirayama, Epidemiology of prostatic cancer with special reference to the role of diet, Natl. Cancer Inst. Monogr. 53: 149 (1979).

    PubMed  Google Scholar 

  7. L. N. Kolonel, J. H. Hankin, J. Lee, S. Y. Chu, A. M. Y. Nomura, M. W. Hinds, Nutrition intakes in relation to cancer incidence in Hawaii, Br. J. Cancer 44: 332 (1981).

    Article  PubMed  CAS  Google Scholar 

  8. A. Hirai, T. Hamazaki, and T. Terano, Eicosapentaenoic acid and platelet function in Japanese, Lancet 2: 1132 (1980).

    Article  PubMed  CAS  Google Scholar 

  9. H. O. Bang, J. Dyerberg, and N. Hjorne, The composition of food consumed by Greenland Eskimos, Acta Med. Scand. 200: 69 (1976).

    Article  PubMed  CAS  Google Scholar 

  10. N. H. Nielsen and J. P. H. Hansen, Breast cancer in Greenland-selected epidemiological, clinical and histological features, J. Cancer Res. Clin. Oncol. 98: 287 (1980).

    Article  PubMed  CAS  Google Scholar 

  11. E. L. Wynder, D. P. Rose, and L. A. Cohen, Breast cancer in causation and therapy, Cancer 58 (Suppl.): 1804 (1986).

    Article  PubMed  CAS  Google Scholar 

  12. K. K. Carroll and H. T. Khor, Dietary fat in relation to tumorigenesis, Prog. Biochem. Pharmacol. 10: 308 (1975).

    PubMed  CAS  Google Scholar 

  13. A. E. Rogers, B. H. Conner, C. L. Bonlanger, S. Y. Lee, F. A. Carr, and W. H. DuMouchil, Enhancement of mammary carcinogenesis in rats fed a high lard diet only before or before and after DMBA, in: Basic and Clinical Aspects of Dietary Fiber, G. Vahouny and D. Kritchevski, eds., Plenum Press (1985).

    Google Scholar 

  14. G. J. Hopkins, T. G. Kennedy, and K. K. Carroll, Polyunsaturated fatty acids as promoters of mammary carcinogenesis induced in Sprague-Dawley rats by 7,12,dimethylbenz(a)anthracene, J. Natl. Cancer Inst. 66: 517 (1981).

    PubMed  CAS  Google Scholar 

  15. R. Kalaneghan and K. K. Carroll, Reversal of the promotional effect of high-fat diet on mammary tumorigenesis by subsequent lowering of dietary fat, Nutr. Cancer 6: 22 (1984).

    Article  Google Scholar 

  16. C. Ip, C. A. Carter, and M. M. Ip, Requirement of essential fatty acid for mammary tumorigenesis in the rat, Cancer Res. 45: 1997 (1985).

    Google Scholar 

  17. R. A. Karmali, Do tissue culture and animal model studies relate to human diet and cancer?, Prog. Lipid Res. 25: 533 (1986).

    Article  PubMed  CAS  Google Scholar 

  18. R. A. Karmali, J. Marsh, and C. Fuchs, Effect of omega-3 fatty acids on growth of a rat mammary tumor, J. Natl. Cancer Inst. 73: 457 (1984).

    PubMed  CAS  Google Scholar 

  19. H. Gabor and S. Abraham, Effect of dietary menhaden oil on growth and cell loss of transplantable mammary adenocarcinoma in BALB/c mice, J. Natl. Cancer Inst. 76: 1223 (1986).

    PubMed  CAS  Google Scholar 

  20. J. J. Jurkowski and W. T. Cave, Jr., Dietary effects of menhaden oil on the growth and membrane lipid composition of rat mammary tumors. J. Natl. Cancer Inst. 74: 1145 (1985).

    PubMed  CAS  Google Scholar 

  21. K. K. Carroll and L. M. Braden, Dietary fat and mammary carcinogenesis, Nutr. Cancer 6: 254 (1985).

    Article  Google Scholar 

  22. C. Ip, M. M. Ip, and P. Sylvester, Relevance of trans fatty acids and fish oil in animal tumorigenesis studies, in: Dietary Fat and Cancer, E. Ip, D. F. Birt, A.E. Rogers, and C. Mettlin, eds., Alan R. Liss, Inc. (1986).

    Google Scholar 

  23. R. A. Karmali, R. U. Doshi, L. Adams, and K. Choi, Effect of n-3 fatty acids on mammary tumorigenesis, Adv. Prost. Thromb. Leukotr. Res. 17: 886 (1987).

    Google Scholar 

  24. T. P. O’Connor, B. D. Roebuck, F. Peterson, and T. C. Campbell, Effect of dietary intake of fish oil and fish protein on the development of L-azaserine-induced preneoplastic lesions in the rat, J. Natl. Cancer Inst. 75: 959 (1985).

    PubMed  Google Scholar 

  25. B. S. Reddy and H. Maruyama, Effect of fish oil on azoxymethaneinduced colon carcinogenesis in male F344 rats, Cancer Res. 46: 3367 (1986).

    PubMed  CAS  Google Scholar 

  26. T. P. O’Connor, F. Peterson, B. Lokesh, J. Kinsella, B. D. Roebuck, and T. C. Campbell, Effect of dietary omega-3:omega-6 ratio on prostaglandin metabolism, membrane fatty acid composition and preneoplastic pancreatic lesion development in rats, Fed. Proc. 46:582, Abs. 1548 (1986).

    Google Scholar 

  27. R. A. Karmali, P. Reichel, L. A. Cohen, T. Terano, A. Hirai, Y. Tamura, and S. Yoshida, The effects of dietary w-3 fatty acids on the DU-145 transplantable human prostatic tumor, Anticancer Res. 7: 1173 (1987).

    PubMed  CAS  Google Scholar 

  28. S. A. Broitman, F. Cannizzo, A. Rogers, and L. S. Gottlieb, Comparison of dietary marine oil and safflower oil on growth and pulmonary colonization of CT-26 implanted into bowel of mice, Fed. Proc. 46:437, Abs. 704 (1987).

    Google Scholar 

  29. L. M. Adams and R. A. Karmali, Inhibition of artificial metastasis in rat mammary tumor 13762 by dietary fish oil, Fed. Proc. 46:437, Abs. 703 (1987).

    Google Scholar 

  30. W. J. Kort, I. M. Weijma, A. M. Bijma, W. P. van Schalkwijk, A. J. Vegroesen, and D. L. Westbroek, Omega-3 fatty acids inhibiting the growth of a transplantable rat mammary adenocarcinoma, J. Natl. Cancer Inst. 79: 593 (1987).

    PubMed  CAS  Google Scholar 

  31. E. B. Katz and E. S. Boylan, Stimulatory effect of high polyunsaturated fat diet on lung metastasis from 13762 mammary adenocarcinoma in female retired breeder rats. J. Natl. Cancer Inst. 79: 351 (1987).

    PubMed  CAS  Google Scholar 

  32. K. V. Honn, R. S. Bockman, and L. J. Marnett, Prostaglandins and cancer: a review of tumor initiation through tumor metastasis, Prost. 21: 833 (1981).

    CAS  Google Scholar 

  33. N. T. Telang, A. Basu, M. J. Modak, and M. P. Osborne, Modulatory influence of fatty acids on induction and promotion of preneoplasia in adult mouse mammary gland organ cultures, Fed. Proc 46:582, Abs. 1546 (1987).

    Google Scholar 

  34. H. Zarbl, S. Sukunar, A. V. Arthur, D. Martin-Zanca, and M. Barbacid, Direct mutagenesis of Ha-ras-1 oncogenes by N-nitro-N-methylurea during initiation of mammary carcinogenesis in rats, Nature (London) 315: 382 (1985).

    Article  CAS  Google Scholar 

  35. M. Barbacid, Mutagens, oncogenes and cancer, in: Oncogenes and Growth Factors, R. A. Bradshaw and S. Prentis eds., pp. 90–99, Elsevier Science Publishers (1987).

    Google Scholar 

  36. S. H. Reynolds, S. J. Stowers, R. R. Maronpot, M. W. Anderson, and S. A. Aaronson, Detection and identification of activated oncogenes in spontaneously occurring benign and malignant hepatocellular tumors of the B6C3F1 mouse, Proc. Natl. Acad. Sci. 83: 33 (1986).

    Article  PubMed  CAS  Google Scholar 

  37. N. J. Agnantis, C. Petraki, P. Markoulatos, and D. A. Spandidas, Immunohistochemical study of the ras oncogene expression in human breast lesions, Anticancer Res. 6: 1157 (1986).

    PubMed  CAS  Google Scholar 

  38. J. Schneider, D. Kinne, A. Fracchia, V. Pierce, K. Anderson, H. L. Bradlow, and J. Fishman, Abnormal metabolism of estradiol in women with breast cancer. Proc. Natl. Acad. Sci. USA 79: 3047 (1982).

    Article  PubMed  CAS  Google Scholar 

  39. M. P. Osborne, H. L. Bradlow, R. Hershkopf, and J. Fishman, A potential marker for the risk of breast cancer: abnormal estradiol 16-alpha-hydroxylation, (Abs.) 37th Annual Meeting of Soc. of Surgical Oncol., New York (1986).

    Google Scholar 

  40. M. P. Osborne, R. A. Karmali, R. J. Hershcopf, H. L. Bradlow, I. Kourides, W. Williams, P. P. Rosen, and J. Fishman, Omega-3 fatty acids, modulation of estrogen metabolism and potential for breast cancer prevention, Cancer Invest. (in press).

    Google Scholar 

  41. S. H. Abou-El-Ela, K. W. Prasse, R. Carroll, and O. R. Bunce, Effects of dietary primrose oil on mammary tumorigenesis by 7,12-dimethylbenz(a)anthracene, Lipids 22: 1041 (1987).

    Article  CAS  Google Scholar 

  42. R. A. Karmali, J. Marsh, C. Fuchs, W. Hare, and M. Crawford, Effects of dietary enrichment with gamma-linolenic acid upon growth of the R3230AC mammary adenocarcinoma, Nutr. Growth Cancer 2: 41 (1985).

    CAS  Google Scholar 

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Karmali, R.A. (1989). Dietary w-3 and w-6 Fatty Acids in Cancer. In: Galli, C., Simopoulos, A.P. (eds) Dietary ω3 and ω6 Fatty Acids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2043-3_32

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  • DOI: https://doi.org/10.1007/978-1-4757-2043-3_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-2045-7

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