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Linoleic Acid and Epidermal Water Barrier

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Abstract

The (n−6)-fatty acids appear to be essential dietary components for mammals and birds (Holman, 1971; Mead and Fulco, 1976), whereas their nutritive importance in fish (Greene and Selvivonchick, 1987) and insect nutrition (de Renobales et al., 1987) are not yet clear. Some insects seem to be able to grow and develop without any polyunsaturated fatty acids’(Sohal et al., 1984; Rapport et al., 1984).

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References

  • Abraham, W., Wertz, P.W., and Downing, D.T, 1985, Linoleate-rich acylglucos•.-lceramides of pig epidermis. Structure detenmrl tion by proton magnetic resonance. J. -d Res., G6: 76.

    Google Scholar 

  • Basnayake, V., and Sinclair, H M 1956, The et deficiency essential fatty acids anon the skin Kcal Problems fr ds G. Pop ak and F,m, eds., Butterworth Scientific Publisher, London.

    Google Scholar 

  • Bowser, P.A., Nugteren, D.H., White, R.J., Houtsmuller, U.M.T., and Prottey, C., 1985, Identification, isolation and characterization of epidermal lipids containg linoleic acid, Biochim. Biophys. Acta 834: 419.

    Google Scholar 

  • Bowser, P.A., and White, R.J., 1985, Isolation, barrier properties and lipid analysis of stratum compactum, a discrete region of stratum corneum, Brit. J. Dermatol. 112: 1.

    Google Scholar 

  • Burr, G.O., and Burr, M.M., 1929, A new deficiency disease produced by rigid exclusion of fat from the diet, J. Biol. Chem. 82: 345.

    Google Scholar 

  • Burr, G.O., and Burr, M.M., 1930, On the nature and role of the fatty acids essential in nutrition, J. Biol. Chem. 86: 587.

    Google Scholar 

  • Cox, P., and Squier, C.A., 1986, Variations in lipids in different layers of porcine epidermis, J. Invest. Dermatol. 87: 741.

    Google Scholar 

  • Renobales, M., Cripps, C., Stanley-Samuelson, D.W., Jurenka, R.A., and Blomquist, G.J., 1987, Biosynthesis of linoleic acid in insects, Trends Biochem. Sci. 12: 364.

    Google Scholar 

  • Elias, P.M., 1981, Lipids and the epidermal permeability barrier, Arch. Dermatol. Res. 270: 95.

    Google Scholar 

  • Elias, P.M., 1983, Epidermal lipides, barrier function, and desquamation, J. Invest. Dermatol. 80: 44.

    Google Scholar 

  • Elias, P.M., 1985, The essential fatty acid deficient rodent - evidence for a direct role of intercellular lipid in barrier function, in: “Models in Dermatology” vol. 1, H.I.Maibach and N.J.Lowe, eds., Karger, Basel.

    Google Scholar 

  • Elias, P.M., Brown, B.E., and Ziboh, V.A., 1980, The permeability barrier in essential fatty acid deficiency. Evidence for a direct role for linoleic acid in barrier function. J. Invest. Dermatol. 74: 230.

    Google Scholar 

  • Elias, P.M., Menon, G.K., Grayson, S., Brown, B.E., and Rehfeld, S.J., 1987, Avian sebokeratinocytes and marine mammal lipokeratinocytes: structural, lipid biochemical, and functional considerations, Am. J. Anatomy 180: 161.

    Google Scholar 

  • Elliott, W.J., Morrison, A.R., Sprecher, H.W., and Needleman, P., 1985a, The metabolic transformations of columbinic acid and the effect of topical application of the major metabolites on rat skin, J. Biol. Chem. 260: 987.

    Google Scholar 

  • Elliott, W.J., Sprecher, H., and Needleman, P., 1985b, Physiologic effects of columbinic acid and its metabolites on rat skin. Biochim. Biophys. Acta 835: 158.

    Google Scholar 

  • Friberg, S.E., and Osborne, D.W., 1985, Small angle X-ray diffraction patterns of stratum corneum and a model structure for its lipids, J. Dispersion Sci. Technol. 6: 485.

    Google Scholar 

  • Golden, G.M., Guzek, D.B., Kennedy, A.H., McKnie, J.E., and Potts, R. O., 1987, Stratum corneum lipid phase transitions and water barrier properties, Biochemistry 26: 2382.

    Article  PubMed  CAS  Google Scholar 

  • Gray, G.M., White, R.J., and Majer, J.R., 1978, 1-(3“-O-acyl)-ßglucosyl-N-dihydroxypentatriacontadienoylsphingosine, a major component of the glucosylceramides of pig and human epidermis, Biochim. Biophys. Acta 528: 127.

    Google Scholar 

  • Greene, D.H.S., and Selivonchick, D.P., 1987, Lipid metabolism in fish, Prog. Lipid Res. 26: 53.

    Google Scholar 

  • Gurr, M.I., 1984, “Role of Fat in Food and Nutrition”, Elsevier Appl. Sci. Publ., London.

    Google Scholar 

  • Hammarlund, K., Nilsson, G.E., Oberg, P.A., and Sedin, G., 1977, Transepidermal water loss in newborn infants. Relation to ambient humidity and site of measurement and estimation of total transepidermal water loss. Acta Padiatr. Scand. 66: 553.

    Google Scholar 

  • Hammarlund, K., Strömberg, B., and Sedin, G., 1986, Heat loss from the skin of preterm and fullterm newborn infants during the first weeks after birth, Biol. Neonate 50: 1.

    Google Scholar 

  • Hansen, H.S., 1986, The essential nature of linoleic acid in mammals, Trends Biochem. Sci. 11: 263.

    Google Scholar 

  • Hansen, H.S., and Jensen, B., 1983, Urinary prostaglandin E2 and vasopressin excretion in essential fatty acid-deficient rats: effect of linolenic acid supplementation, Lipids 18: 682.

    Article  PubMed  CAS  Google Scholar 

  • Hansen, H.S., and Jensen, B., 1985, Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and a-linolenate, Biochim. Biophys. Acta 834: 357.

    Google Scholar 

  • Hansen, H.S., and Jensen, B., 1987, Why is linoleic acid essential ? in: “Proc. AOCS Short Course on Polyunsaturated Fatty Acids and Eicosanoids”, W.E.M.Lands, ed., American Oil Chemists“ Society, Champaign, Illinois.

    Google Scholar 

  • Hansen, H.S., Jensen, B., and von Wettstein-Knowles, P., 1986, Apparent in vivo retroconversion of dietary arachidonic to linoleic acid in essential fatty acid-deficient rats, Biochim. Biophys. Acta 878: 284.

    Google Scholar 

  • Hartop, P.J., and Prottey, C., 1976, Changes in transepidermal water loss and the composition of epidermal lecithin after applications of pure fatty acid triglycerides to the skin of essential fatty acid-deficient rats, Br. J. Dermatol. 95: 255.

    Google Scholar 

  • Holman, R.T., 1971, Essential fatty acid deficiency, Prog. Chem. Fats Lipids9: 275.

    Google Scholar 

  • Houtsmuller, U.M.T., 1975, Specific biological effects of polyunsaturated fatty acids, in: “The Role of Fat in Human Nutrition”, A.J.Vergroesen, ed., Academic Press, London.

    Google Scholar 

  • Houtsmuller, U.M.T., and van der Beek, A., 1981, Effects of topical application of fatty acids, Prog. Lipid Res. 20: 219.

    Google Scholar 

  • Jelenko, C., Wheeler, M.L., and Scott, T.H., 1972a, Studies in burns, X. Ethyl linoleate: the water holding lipid of skin, J. Trauma. 12: 968.

    Article  PubMed  Google Scholar 

  • Jelenko, C., Wheeler, M.C., and Scott, T.H., 1972b, Studies in burns, XI. Ethyl linoleate: effects on in vivo burn eschar, J. Trauma. 12: 974

    Article  PubMed  Google Scholar 

  • Lampe, M.A., Burlingame, A.L., Whitney, J., Williams, M.L., Brown, B. E., Roitman, E., and Elias, P.M., 1983, Human stratum corneum lipids: characterization and regional variations, J. Lipid Res. 24: 120.

    PubMed  CAS  Google Scholar 

  • Landmann, L., 1984, The epidermal permeability barrier. Comparison between in vivo and in vitro lipid structures Eur. J. Cell. Biol. 33: 258.

    Google Scholar 

  • Landmann, L., Wertz, P.W., and Downing, D.T., 1984, Acylglucosylceramide causes flattening and stacking of liposomes. An analogy for assembly of the epidermal permeability barrier. Biochim. Biophys. Acta 778: 412.

    Google Scholar 

  • Madison, K.C., Swartzendruber, D.C., Wertz, P.W., and Downing, D.T., 1988, Lamellar granule extrusion and stratum corneum intercellular lamellae in murine keratinocyte cultures. J. Invest. Dermatol. 90: 110.

    Google Scholar 

  • Mead, J.F., and Fulco, A.J., 1976, “The Unsaturated and Polyunsaturated Fatty Acids in Health and Disease”, Charles C. Thomas Publisher, Springfiled, U.S.A.

    Google Scholar 

  • Melton, J.L., Wertz, P.W., Swartzendruber, D.C., and Downing, D.T., 1987, Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs, Biochim. Biophys. Acta 921: 191.

    Google Scholar 

  • Nugteren, D.H., Christ-Hazelhof, E., van der Beek, A., and Houtsmuller, U.M.T., 1985, Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat, Biochim. Biophys. Acta 834: 429.

    Google Scholar 

  • Nugteren, D.H., and Kivits, G.A.A., 1987, Conversion of linoleic acid and arachidonic acid by skin epidermal lipoxygenases, Biochim. Biophys. Acta 921: 135.

    Google Scholar 

  • Prottey, C., 1977, Investigation of functions of essential fatty acids in the skin, Br. J. Dermatol. 97: 29.

    Google Scholar 

  • Rapport, E.W., Stanley-Samuelson, E., and Dadd, R.H., 1984, Ten generations of drosophila melanogaster reared axenically on a fatty acid-free holidic diet, Arch. Insect Biochem. Physiol. 1: 243.

    Google Scholar 

  • Scheuplein, R.J., 1976, Permeability of the skin: a review of major concepts and some new developments, J. Invest. Dermatol. 67: 672.

    Google Scholar 

  • Sinclair, H.M., 1952, Essential fatty acids and their relation to pyridoxine, in: “Lipid Metabolism”, R.T.Williams, ed., The University Press, Cambridge, UK.

    Google Scholar 

  • Sohal, R.S., Bridges, R.G., and Howes, E.A., 1984, Relationship between lipofuscin granules and polyunsaturated fatty acids in the house fly, Musca Domestica, Mechanism Age. Develop. 25: 355.

    Google Scholar 

  • Squier, C.A., and Hall, B.K., 1985, The permeability of skin and oral mucosa to water and horseradish peroxidase as related to the tickness of the permeability barrier, J. Invest. Dermatol. 84: 176.

    Google Scholar 

  • Thomasson, H.J., 1953, Biological standardization of essential fatty acids (a new method), Int. Rev. Vitamin Res. 25: 62

    Google Scholar 

  • Thomasson, H.J., 1962, Essential fatty acids, Nature 194: 973.

    Article  PubMed  CAS  Google Scholar 

  • Wertz, P.W., Cho, E.S., and Downing, D.T., 1983, Effect of essential fatty acid deficiency on the epidermal sphingolipids of the rat, Biochim. Biophys. Acta 753: 350.

    Google Scholar 

  • Wertz, P.W., Cox, P.S., Squier, C.A., and Downing, D.T., 1986, Lipids of epidermis and keratinized and non-keratinized oral epithelia, Comp. Biochem. Physiol. 83B: 529.

    Google Scholar 

  • Wertz, P.W., and Downing, D.T., 1982, Glycolipids in mammalian epidermis: structure and function in the water barrier, Science 217: 1261.

    Article  PubMed  CAS  Google Scholar 

  • Wertz, P.W., and Downing, D.T., 1983, Ceramides of pig epidermis. Structure determination, J. Lipid Res. 24: 759.

    Google Scholar 

  • Wertz, P.W., and Downing, D.T., 1986, Linoleate content of epidermal acylglucosylceramide in newborn, growing and mature mice, Biochim. Biophys. Acta 876: 469.

    Google Scholar 

  • Wertz, P.W., Donald, C., Swartzendruber, C., Abraham, W., Madison, K.C., and Downing, D.T., 1987, Essential fatty acids and epidermal integrity, Arch. Dermatol. 123: 1381.

    Google Scholar 

  • Yardley, H.J., and Goldstein, D.J., 1976, Changes in dry weight and projected area of human epidermal cells undergoing keratinization as determined by scanning interference microscopy, Br. J. Dermatol. 95: 621.

    Google Scholar 

  • Yardley, H.J., and Summerly, R., 1981, Lipid composition and metabolism in normal and diseased epidermis, Pharmac. Ther. 13: 357.

    Google Scholar 

  • Ziboh, V.A., and Hsia, S.L., 1972, Effects of prostaglandin E2 on rat skin: Inhibition of sterol ester biosynthesis and clearing of scaly lesions in essential fatty acid deficiency, J. Lipid Res. 13: 458.

    Google Scholar 

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© 1989 Springer Science+Business Media New York

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Hansen, H.S. (1989). Linoleic Acid and Epidermal Water Barrier. In: Galli, C., Simopoulos, A.P. (eds) Dietary ω3 and ω6 Fatty Acids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2043-3_30

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  • DOI: https://doi.org/10.1007/978-1-4757-2043-3_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-2045-7

  • Online ISBN: 978-1-4757-2043-3

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