Abstract
The retina and brain contain exceptionallyy high concentrations of docosahexaenoic acid (DHA, or 22:6 omega-3).1–3 This fatty acid is a component of the phospholipids, especially phosphatidylethanolamine and phosphatidylserine, which are basic structural constituents of cell membranes. Particularly rich in DHA are specialized neural membrans, such as those of synaptic endings4’5 and photoreceptor outer segments.6,7
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References
R.E. Anderson. Lipids of ocular tissues. IV. A comparison of the phospholipids from the retina of six mammalian species. Exp. Eye Res. 10: 339–344 (1970).
J.S. O’Brien and E.L. Sampson. Fatty acid and fatty aldehyde composition of the major brain lipids in normal human gray matter, white matter, and myelin. J. Lipid Res. 6: 545–551 (1965).
L. Svennerholm. Distribution and fatty acid composition of phosphoglycerides in normal human brain. J. Lipid Res. 9: 570–579 (1968).
W.C. Breckenridge, I.G. Morgan, J.P. Zanetta, and G. Vincendon. Adult rat brain synaptic vesicles. II. Lipid composition. Biochim. Biophys. Acta 320: 681–686 (1973).
C. Cotman, M.L. Blank, A. Moehl, and F. Snyder. Lipid composition of synaptic plasma membranes isolated from rat brain by zonal ultracentrifugation. Biochemistry 8: 4606–4612 (1969).
R.E. Anderson, R.M. Benolken, P.A. Dudley, D.J. Landis, and T.G. Wheeler. Polyunsaturated fatty acids of photoreceptor membranes. Exp. Eye Res. 18: 205–213 (1974).
W.L. Stone, C.C. Farnsworth, and E.A. Dratz. A reinvestigation of the fatty acid content of bovine, rat and frog retinal rod outer segments. Exp. Eye Res. 28: 387–397 (1979).
F.J.M. Daemen. Vertebrate rod outer segment membranes. Biochim. Biophys. Acta 300:255–288 (1973).
R.E. Anderson and L. Sperling. Lipids of ocular tissues. VII. Positional distribution of the fatty acids in the phospholipids of bovine retina rod outer segments. Arch. Biochem. Biophys. 144:673–677 (1971).
R.D. Wiegand and R.E. Anderson. Phospholipid molecular species of frog rod outer segment membranes. Exp. Eye Res. 37: 159–173 (1983).
R.E. Anderson and L.D. Andrews. Biochemistry of retinal photoreceptor membranes in vertebrates and invertebrates, in: “Visual Cells in Evolution,” J. Westfall, ed., Raven Press, New York (1982).
M.I. Aveldano and N.G. Bazan. Molecular species of phosphatidylcholine, -ethanolamine, -serine, and -inositol in microsomal and photoreceptor membranes of bovine retina. J. Lipid Res. 24: 620–627 (1983).
N.M. Giusto, M.I. De Boschero, H. Sprecher and M.I. Aveldano. Active labeling of phosphatidylcholines by [1-14C]docosahexaenoate in isolated photoreceptor membranes. Biochim. Biophys. Acta 860:137148 (1986).
N.P. Rotstein and M.I. Aveldano. Labeling of lipids of retina subcellular fractions by [1-14C]eicosatetraenoate (20:4(n-6)), docosapentaenoate (22:5(n-3)) and docosahexaenoate (22:6(n-3)). Biochim. Biophys. Acta 921:221–234 (1987).
J. Tinoco, P. Miljanich and B. Medwadowski. Depletion of docosahexaenoic acid in retinal lipids of rats fed a linolenic acid-deficient, linoleic acid-containing diet. Biochim. Biophys. Acta 486:575–578 (1977).
R.D. Wiegand, C.D. Joel, L.M. Rapp, J.C. Nielsen, M.B. Maude and R.E. Anderson. Polyunsaturated fatty acids and vitamin E in rat rod outer segments during light damage. Invest. Ophthalmol. Vis. Sci. 27: 727–733 (1986).
R.D. Wiegand, L.M. Rapp and R.E. Anderson. Ferrous ion-induced retinal degeneration: Biochemical changes in photoreceptor membranes. Invest. Ophthalmol. Vis. Sci. 26 (Supp1.3): 65 (1985).
R.W. Young. The renewal of photoreceptor cell outer segments. J. Cell Biol. 33: 61–72 (1967).
R.J. Mullen and M.M. LaVail. Inherited retinal dystrophy: Primary defect in pigment epithelium determined with experimental rat chimeras. Science 192: 799–801 (1976).
S.J. Fliesler and R.E. Anderson. Chemistry and metabolism of lipids in the vertebrate retina. Prog. Lipid Res. 22: 79–131 (1983).
M.L. Applebury and P.A. Hargrave. Molecular biology of the visual pigments. Vision Res. 26: 1881–1896 (1986).
A.A. Lamola, T. Yamane and A. Zipp. Effects of detergents and high pressures upon the metarhodopsin I to metarhodopsin II equilibrium. Biochemistry 15: 738–745 (1974).
R.A. Cone and W.H. Cobbs. Rhodopsin cycle in the living eye of the rat. Nature 221: 820–822 (1969).
P.K. Brown. Rhodopsin rotates in the visual receptor membrane. Nature New Biology 236: 35–38 (1972).
R.A. Cone. Rotational diffusion of rhodopsin in the visual receptor membrane. Nature New Biology 236: 39–43 (1972).
K.P. Coolbear, C.B. Bearde, and K.M.W. Keough. Gel to liquid-crystalline phase transitions of aqueous dispersions of polyunsaturated mixed acid phosphatidylcholines. Biochemistry 22: 1466–1473 (1983).
E.A. Dratz and A.J. Deese. The role of docosahexaenoic acid (22:6n-3) in biological membranes: Examples from photoreceptors and model membrane bilayers, in: “Health Effects of Polyunsaturated Fatty Acids in Seafoods,” A.P. Simopoulos, ed., Academic Press, New York (1986).
T.S. Weidmann, R.D Pates, J.M. Beach, A. Salmon, and M.F. Brown. Lipid-protein interactions mediate the photochemical function of rhodopsin. Biochemistry 27: 6469–6474 (1988).
E.A. Dratz, N. Ryba, A. Watts, and A.J. Deese. Studies of the essential role of docosahexaenoic acid (DHA), 22:6 omega-3, in visual excitation. Invest. Ophthalmol. Vis. Sci. 28 (Supp1.3): 96 (1987).
M.R. Paddy and F.W. Dahlquist. Simultaneous observation of order and dynamics at several defined positions in the single acyl chain using 2H NMR of single acyl chain perdeuterated phosphatidylcholines. Biochemistry 24: 5988–5995 (1985).
F. Millett, P.A. Hargrave, and M.A. Raftery. Natural abundance 13C nuclear magnetic resonance spectra of the lipid in intact bovine retinal rod outer segment membranes. Biochemistry 12: 3591–3592 (1973).
C. Arus, W.M. Westler, M. Barany, and J.L. Markley. Observation of the terminal methyl group in fatty acids of the linolenic series by a new 1H NMR pulse sequence providing spectral editing and solvent suppression. Application to excised frog muscle and rat brain. Biochemistry 25: 3346–3351 (1986).
C.D. Stubbs and A.D. Smith. The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochim. Biophys. Acta 779: 87–137 (1984).
A.A. Spector and M.A. Yorek. Membrane lipid composition and cellular function. J. Lipid Res. 26: 1015–1035 (1985).
J. Bernsohn and F.J. Spitz. Linoleic and linolenic acid dependency of some brain membrane-bound enzymes after lipid deprivation in rats. Biochem. Biophys. Res. Commun. 57: 293–298 (1974).
A. Orlacchio, C. Maffei, L. Binaglia, and G. Porcellati. The effect of membrane phospholipid acyl-chain composition on the activity of brain B-N-acetyl-D-glucosaminidase. Biochem. J. 195: 383–388 (1981).
R. Tanaka. Comparison of lipid effects on K+-Mg2+ activated pnitrophenyl phosphatase and Na+-K+-Mg2+ activated adenosine triphosphatase of membrane. J. Neurochem. 16: 1301–1307 (1969).
M. Foot, T.F. Cruz, and M.T. Clandinin. Effect of dietary lipid on synaptosomal acetylcholinesterase activity. Biochem. J. 211: 507–509 (1983).
N. Salem, H.-Y. Kim, and J.A. Yergey. Docosahexaenoic acid: Membrane function and metabolism, in: “Health Effects of Polyunsaturated Fatty Acids in Seafoods,” A.P. Simopoulos, ed., Academic Press, New York (1986).
V.A. Tyurin and N.V. Gorbunov. Fatty acid composition of aminophospholipids in protein microenvironment of plasmatic synaptic membranes of the brain in rat (in Russian). J. Evol. Biochem. Physiol. 591–594 (1983).
A.J. Deese, E.A. Dratz, F.W. Dahlquist, and M.R. Paddy. Interaction of rhodopsin with two unsaturated phosphatidylcholines: A deuterium nuclear magnetic resonance study. Biochemistry 20: 6420–6427 (1981).
M.A. Yorek, R.R. Bohnker, D.T. Dudley, and A.A. Spector. Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y79 retinoblastoma cells. Biochim. Biophys. Acta 795:277–285, (1984).
N.G. Bazan, D.L. Birkle, and T.J. Reddy. Docosahexaenoic acid (22:6n-3) is metabolized to lipoxygenase reaction products in the retina. Biochem. Biophys. Res. Commun. 125: 741–747 (1984).
E.L. Berson. Electroretinographic testing as an aid in determining visual prognosis in families with hereditery retinal degenerations, in: “Retina Congress,” R.C. Pruett and C.D.J. Regan, eds., Appleton-Century-Crofts, New York (1974).
R.M. Benolken, R.E. Anderson, and T.G. Wheeler. Membrane fatty acids associated with the electrical response in visual excitation. Science 182: 1253–1254 (1973).
T.G. Wheeler, R.M. Benolken, and R.E. Anderson. Visual membranes: Specificity of fatty acid precursors for the electrical response to illumination. Science 188: 1312–1314 (1975).
A. Nouvelot, E. Dedonder, P. Dewailly, and J.M. Bourre. Influence des n-3 exogenes sur la composition en acides gras polyinsatures de la retine, aspects structural et physiologique. Cah. Nutr. Diet. 20: 123–125 (1985).
I. Watanabe, M. Kato, H. Aonuma, A. Hasimoto, Y. Naito, A. Moriuchi, and H. Okuyama. Effect of dietary alpha-linolenate/linoleate balance on the lipid composition and electroretinographic responses in rats. Adv. Biosciences 62: 563–570 (1987).
M.A. Lamptey and B.L. Walker. A possible essential role for dietary linolenic acid in the development of the young rat. J. Nutr. 106: 86–93 (1976).
N. Yamamoto, M. Saitoh, A. Moriuchi, M. Nomura, and H. Okuyama. Effect of dietary alpha-linoleate/linoleate balance on brain lipid compositions and learning ability of rats. J. Lipid Res. 28: 144–151 (1987).
M. Neuringer, W.E. Connor, C. Van Petten, and L. Barstad. Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. J. Clin. Invest. 73: 272–276 (1984).
M. Neuringer, W.E. Connor, D.S. Lin, L. Barstad, and S. Luck. Biochemical and functional effects of prenatal and postnatal omega-3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc. Natl. Acad. Sci. USA. 83: 4021–4025 (1986).
W.E. Connor, M. Neuringer, and D. Lin. The incorporation of docosahexaenoic acid into the brain of monkeys deficient in omega-3 essential fatty acids. Clin. Res. 33: 598A (1985).
M. Neuringer, W.E. Connor, D. Daigle, and L. Barstad. Electroretinogram abnormalities in young infant rhesus monkeys deprived of omega-3 fatty acids during gestation and postnatal development or only postnatally. Invest. Ophthalmol. Vis. Sci. 29 (Suppl. 3): 145 (1988).
B.L. Walker. Maternal diet and brain fatty acids in young rats. Lipids 2: 497–500 (1967).
S.E. Carlson, P.G. Rhodes, and M.G. Ferguson. Docosahexaenoic acid status of preterm infants at birth and following feeding with human milk or formula. Am. J. Clin. Nutr. 44: 798–804 (1986)
S.E. Carlson, P.G. Rhodes, V. S. Rao, and D.E. Goldgar. Effect of fish oil supplementation on the n-3 fatty acid content of red blood cell membranes in preterm infants. Pediatr. Res. 21: 507–510 (1987).
M.A. Crawford, A.G. Hassam, and B.M. Hall. Metabolism of essential fatty acids in the human fetus and neonate. Nutr. Metab. 21: 187188 (1977).
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Neuringer, M., Connor, W.E. (1989). Omega-3 Fatty Acids in the Retina. In: Galli, C., Simopoulos, A.P. (eds) Dietary ω3 and ω6 Fatty Acids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2043-3_16
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DOI: https://doi.org/10.1007/978-1-4757-2043-3_16
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