Abstract
Renal papillary necrosis (RPN) in man can follow the abuse of non narcotic analgesics or nonsteroidal anti-inflammatory drugs (NSAIDs). Secondary cortical interstitial nephritis may also occur. In extreme cases affected kidneys can progress to end-stage renal failure (ESRF) or upper urothelial carcinoma (UUC).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Bach, P.H., Bridges, J.W. Chemical associated renal papillary necrosis. In: Nephrotoxicity: Assessment and Pathogenesis, eds: P.H. Bach, F.W. Bonner, J.W. Bridges, E.A. Lock. pp 437–459 John Wiley, Chichester, 1982.
Bach, P.H., Bridges, J.W. The role of metabolic activation of analgesics and nonsteroidal anti-inflammatory drugs in the development of renal papillary necrosis and upper urothelial carcinoma. Prostaaland Leuk Med 15:251–274, 1984.
Bach, P.H., Hardy, T.L. Relevance of animal models to analgesic-associated renal papillary necrosis in humans. Kidney Int 28:605–613, 1985.
Bokelman, D.L., Bagdon, W.J., Mattis, P.A., Stonier, P.F. Strain-dependent renal toxicity of a nonsteroid anti-inflammatory agent. Toxicol Appl Pharmacol 19:111–124, 1971.
Emerson, J.L., Gibson, W.R., Pierce, E.C., Todd, G.E. Pre-clinical toxicology of fenoprofen. Toxicol Appl Pharmacol 25:444 Abstract, 1973.
Emerson, J.L. Chronic oral toxicity of a nonsteroidal anti-inflammatory reagent in rhesus monkeys. Toxicol Appl Pharmacol 37:184, 1976.
Goodwin, J.W. Immunologic effects of nonsteroidal anti-inflammatory drugs. Amer J Med 77:7–15, 1984. Gunson, D.E. Renal papillary necrosis in horses. J Am Med Ass 182:2 63–266, 1983.
Hobbs, D.C., Twomey, T.M. Piroxicam pharmacokinetics in man: aspirin and antacid studies. J Clin Pharmacol 19:270–281, 1979.
Hobbs D.C., Twomey, T.M. Metabolism of piroxicam by laboratory animals. Drugs Metab Disp 9:114–118, 1981.
Kaump, D.H. Pharmacology of the fenamates II. Toxicology in animals. Ann Phvsiol Med (Suppl) pp 16–23, 1966.
Mazue, G., Vallee, E., Genet, P., Navorro, J., Brunaud, M. Studies of Buxcloxic acid (804 CB). Arzneim-Forsch (Drug Res) 9a:1398–1413, 1974.
Mazue, G., Berthe, J., Richer, G., Vallee, E. Parsalmide: A new anti-inflammatory agent. Note IX: Toxicological study of parsalmide; oral toxicity study in baboons. Boll Clin Farma 115:216–229, 1976.
Rosner, I. Experimental analgesic nephropathy. CRC Crit Rev Toxicol 4: 331–352, 1976.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer Science+Business Media New York
About this chapter
Cite this chapter
Skelton-Stroud, P.N. (1989). The Renal Response of a Nonhuman Primate (Baboon) to Certain Nonsteroidal Anti-Inflammatory Drugs. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_62
Download citation
DOI: https://doi.org/10.1007/978-1-4757-2040-2_62
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-2042-6
Online ISBN: 978-1-4757-2040-2
eBook Packages: Springer Book Archive