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Investigations on the Nephrotoxic Potential Of Recombinant Human Tumour Necrosis Factor

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Nephrotoxicity

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Abstract

Tumour necrosis factor (TNF) is a protein produced by macrophages and monocytes after induction with endotoxin. It has the same primary structure as cachectin which is an important mediator of toxic shock and both substances are probably identical.

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References

  1. B. Beutler, A. Cerami, Cachectin: More than a tumor necrosis factor, N Enal J Med. 316:379–384 (1987).

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  2. R. Munker, H.Ph. Koeffler, Tumor necrosis factor, Recent Adv Klin Wochenschr. 65:345–352 (1987)

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  3. D. Maruhn, I. Fuchs, G. Mues, K.D. Bock, Normal limits of urinary excretion of eleven enzymes, Clin Chem. 22:1567–1574 (1976)

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Author information

Authors and Affiliations

  1. Department of Renal and Hypertensive Diseases, University Medical School, Hufelandstr. 55, D-4300, Essen, Germany

    Ulrike Metz-Kurschel

  2. West German Tumour Centre, University Medical School, Hufelandstr.55, D-4300, Essen, Germany

    Erhard Kurschel & Norbert Niederle

Authors
  1. Ulrike Metz-Kurschel
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  2. Erhard Kurschel
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  3. Norbert Niederle
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Editor information

Editors and Affiliations

  1. The Robens Institute of Industrial and Environmental Health and Safety, University of Surrey, Guildford, Surrey, UK

    P. H. Bach

  2. ICI Central Toxicology Laboratory, Macclesfield, Cheshire, UK

    E. A. Lock

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© 1989 Springer Science+Business Media New York

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Metz-Kurschel, U., Kurschel, E., Niederle, N. (1989). Investigations on the Nephrotoxic Potential Of Recombinant Human Tumour Necrosis Factor. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_105

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  • DOI: https://doi.org/10.1007/978-1-4757-2040-2_105

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-2042-6

  • Online ISBN: 978-1-4757-2040-2

  • eBook Packages: Springer Book Archive

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