Abstract
The potent diuretic, natriuretic, vasorelaxant and endocrine effects of atrial natriuretic peptides isolated from several mammals (rat, monkey, pig, man) have been extensively investigated (1–5) and this knowledge is being applied in the treatment of cardiorenal disease (6, 7). The evidence as to the mechanisms underlying these effects is still incomplete (5). In an attempt to establish the existence and actions of a natriuretic factor we assayed the biological activity of a partially purified fraction isolated in our laboratory from bovine heart atria (AF) on diuresis and natriuresis in the anaesthetised dog, on mammalian vascular smooth muscle, small intestine, on the rate of active sodium transport in isolated toad skin, and on the response of the skin to aldosterone and to angiotensin II (Agt II). The action of synthetic atrial natriuretic peptide (Atriopeptin III, ANP) on the isolated toad skin was also examined.
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References
A.J. DeBold, H.B. Borensteia, A.T. Veress and H. Sonnenberg, A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats, Life Sci 28:89 (1981).
U. Ackerman, Structure and function of atrial natriuretic peptides, Clin Chem 32:214 (1986).
H.D. Kleinert and T. Maack, Renal and cardiovascular effects of atrial natriuretic factor, Biochem Pharmacol 35:2057 (1986).
J.H. Laragh, The endocrine control of blood volume, blood pressure and sodium balance: atrial hormone and renin system interactions, Hypertension 4:S143 (1986).
R. Gerzer, J.M. Heim, B. Schutte and J. Weil, Cellular mechanism of action of atrial natriuretic factor, Klin Wochenschr 65: 109 (1987).
J.H. Laragh, Endocrine mechanisms in congestive failure. Renin, aldosterone and atrial natriuretic hormone, Drugs 31:1 (1986).
G. Thibault, R. Garcia, J. Gutkowska, J. Genest and M. Cantin, Atrial natriuretic factor. A newly discovered hormone with Significant clinical implications, Drugs 31:369 (1986).
B.C. Norris, C. Pantoja, J.B. Concha and L.Ch. Chiang, Effect of bovine heart atrial natriuretic and diuretic fractions on sodium transport in isolated toad skin, Pharmacology 33:157 (1986).
H.H. Ussing and K. Zerahn, Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. Acta Physiol Scand 23: 110 (1951).
L.C. Isaacson, Resolution of parameters in the equivalent electrical circuit of the sodium transport mechanism across toad skin, J. Membrane Biol 30:301 (1977).
B.A. Breuhaus, H.H. Saneil, M.A. Brandt and J.E. Chimoskey, Atriopeptin II lowers cardiac output in conscious sheep, Am J Physiol 249:R776 (1985).
J.C. Burnett, J.P. Granger and T.J. Opgenorth, Effects of synthetic atrial natriuretic factor on renal function and renin release, Am J Physiol 247:F863 (1984).
H. Sonnenberg, On the physiological role of atrial natriuretic factor, Klin Wochenschr 65 (Suppl VIII): 8 (1987).
D.M. Tal, S. Katchalsky, D. Lichtstein and J.D. Karlish, Endogenous “Ouabain-like” activity in bovine plasma, Biochem Biophvs Res Commun 135: 1 (1986).
M. Hropot, E. Klaus, J. Knolle, W. Konig and W. Scholz, Klin Wochenschr 64 (Suppl VI):58 (1986).
B. Leckie, How the heart rules the kidneys, Nature 326: 644 (1987).
P. Bolli, F.B. Muller, L. Linder, A.E.G. Raine, T.J. Resink, P. Erne, W. Kioski, R. Hitz and F.R. Buhler, The vasodilator potency of atrial natriuretic peptide in man, Circulation 75:221 (1987).
T.G. Hammond, A.N. Yusufi, F.G. Knox and T.P. Dousa, Administration of atrial natriuretic factor inhibits sodium-coupled transport in proximal tubules, J Clin Invest 75:1983 (1985).
C.V. Pantola, L.Ch. Chiang, B.C. Norris and J.B. Concha, Rapid method for the partial purification of atrial natriuretic factor, IRCS Med Sci 14: 611 (1986).
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© 1989 Springer Science+Business Media New York
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Norris, B., Concha, J., Cuiang, L., Pantoja, C. (1989). Partially Purified Bovine Atrial Fraction on Animal Kidney, Smooth Muscle and Sodium Transport in Toad Skin. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_104
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DOI: https://doi.org/10.1007/978-1-4757-2040-2_104
Publisher Name: Springer, Boston, MA
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