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Biology of Growth Factors pp 65–73Cite as

Regulation of Cell Growth and Transformation by the Epidermal Growth Factor Receptor

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 234))

Abstract

Epidermal growth factor (EGF) is a small peptide growth factor which mediates its response by a membrane glcoprotein denoted as the EGF-receptor,(reviewed in 1–2). Following the purification of the EGF-receptor,3 and its partial sequencing,4 the complete primary structure of the EGF-receptor was deduced from nucleotide sequence of cDNA clones.5 The mature receptor is composed of 1,186 amino acid residues that are preceded at the NH2-terminal end by a signal peptide of 24 hydrophobic amino acids. The signal peptide is cleaved after insertion of the nascent receptor into the membrane of the endoplasmic reticulum. Cotranslationally, the receptor is glycosylated and transported through the Golgi apparatus to the plasma membrane. The mature receptor is composed of three major structural elements. An extracellular EGF-binding domain composed of 621 amino acid residues, anchored to the plasma membrane by a single transmembrane region of 23 hydrophobic amino acids. The transmembrane region is followed by a sequence of mostly basic residues; a feature common to many membrane proteins.

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Author information

Authors and Affiliations

  1. Rorer Biotechnology, Inc., 4 Research Court, Rockville, Maryland, 20850, USA

    Joseph Schlessinger

  2. Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel

    Joseph Schlessinger

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  1. Joseph Schlessinger
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Editor information

Editors and Affiliations

  1. Department of Clinical Biochemistry and Medicine and Banting and Best Diabetes Centre, University of Toronto General Hospital, Toronto, Ontario, Canada

    Jeffrey E. Kudlow

  2. Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada

    David H. MacLennan

  3. Department of Medical Genetics and Medical Biophysics, University of Toronto and Division of Molecular and Developmental Biology Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada

    Alan Bernstein

  4. Department of Pathology and Banting and Best Diabetes Centre, University of Toronto and Toronto General Hospital General Hospital, Toronto, Ontario, Canada

    Avrum I. Gotlieb

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© 1988 Springer Science+Business Media New York

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Schlessinger, J. (1988). Regulation of Cell Growth and Transformation by the Epidermal Growth Factor Receptor. In: Kudlow, J.E., MacLennan, D.H., Bernstein, A., Gotlieb, A.I. (eds) Biology of Growth Factors. Advances in Experimental Medicine and Biology, vol 234. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1980-2_6

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  • DOI: https://doi.org/10.1007/978-1-4757-1980-2_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1982-6

  • Online ISBN: 978-1-4757-1980-2

  • eBook Packages: Springer Book Archive

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