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Criteria for Standardizing and Judging Viability Placental Perfusions in Animals

A Workshop Report

  • Chapter
Cellular Biology and Pharmacology of the Placenta

Part of the book series: Trophoblast Research ((TR))

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Abstract

The recommendations in this manuscript are derived from a workshop which was held on October 7, 1985. In addition to input supplied by the participants, a number of articles published between 1967 and 1985 were examined for trends in criteria reported. These articles did not comprise an exhaustive literature search; rather they represented a very selective survey. The purpose of this manuscript is to describe criteria which the participants felt should used to determine the viability of placentae during perfusions.

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References

  • Bailey, D.J., Bradbury, M.W., France, U.M., Hedley, R., Naik, S., and Parry, H. (1979) Cation transport across the guinea-pig placenta perfused in situ. J. Physiol. (Lond.) 287, 45–56.

    Google Scholar 

  • Baker, E. and Morgan, E.H. (1970) Iron transfer across the perfused rabbit placenta. Life Sci. 9, 773–779.

    Google Scholar 

  • Bissonnette, J.M. (1975) Control of vascular volume in sheep umbilical circulation. J. Appl. Physiol. 38,1057–1061.

    Google Scholar 

  • Bissonnette, J.M. and Farrell, R.C. (1973) Pressure-flow and pressure-volume relationships in the fetal placental circulation. J. Appl. Physiol. 35, 355–360.

    CAS  PubMed  Google Scholar 

  • Bissonnette, J.M. and Gurtner, G.H. (1972) Transfer of inert gases and tritiated water across the sheep placenta. J. Appl. Physiol. 32, 64–69.

    Google Scholar 

  • Bloxam, D.L., Tyler, C.F., and Young, M. (1981) Foetal glutamate as a possible precursor of placental glutamine in the guinea pig. Biochem. J. 198, 397–401.

    Google Scholar 

  • Carroll, M.J. (1981) Short communication: The influence of perfusion in situ on lactate and pyruvate levels in guinea pig placenta. Placenta 2, 271–272.

    Article  CAS  PubMed  Google Scholar 

  • Carstensen, M.H., Leichtweiss, H.P., and Schröder, H. (1982a) The metabolism of the isolated artificially perfused guinea pig placenta. II. Difference of excretion of hydrogen ions, ammonia, carbon dioxide, and lactate into maternal and fetal veins. J. Perinat. Med. 10, 154–160.

    Article  CAS  PubMed  Google Scholar 

  • Carstensen, M.H., Leichtweiss, H.P., and Schröder, H. (1982b) The metabolism of the isolated artificially perfused guinea pig placenta. I. Excretion of hydrogen ions, ammonia, carbon dioxide, and lactate, and the consumption of oxygen and glucose. J. Perinat. Med. 10, 147–153.

    Article  CAS  PubMed  Google Scholar 

  • Eaton, B.M. and Yudilevich, D.L. (1981) Uptake and asymmetric efflux of amino acids at maternal and fetal sides of placenta. Am. Physiol. Soc. 241, C106 - C112.

    CAS  Google Scholar 

  • Faber, J.J., Hart, F.M., and Poutala, A.C. (1968) Diffusional resistance of the innermost layer of the placental barrier of the rabbit. J. Physiol. (Loud.) 197, 381–393.

    CAS  Google Scholar 

  • Fenton, E. (1977) Technique for in situ perfusion of the guinea pig placenta. Biol. Neonate 32, 1–4.

    Article  CAS  PubMed  Google Scholar 

  • Fenton, E., Britton, H.G., and Nixon, D.A. (1976) A study of the permeability of the guinea pig placenta to citrate using recirculating placental perfusion technique. Biol. Neonate 29, 299–305.

    Article  CAS  PubMed  Google Scholar 

  • Forsling, M.L. and Fenton, E. (1977) Permeability of the foetal guinea-pig placental to arginine-vasopressin. J. Endocrinol. 72, 409–410.

    Article  CAS  PubMed  Google Scholar 

  • Hanshaw-Thomas, A., Roserson, N., and Reynolds, F. (1984) Transfer of bupivacaine, lignocaine, and pethidine across the rabbit placenta: Influence of maternal protein binding and fetal flow. Placenta 5, 61–70.

    Article  Google Scholar 

  • Hedley, R. and Bradbury, M.W.B. (1980) Transport of polar non-electrolytes across the intact and perfused guinea-pig placenta. Placenta 1, 277–285.

    Article  CAS  PubMed  Google Scholar 

  • Herberger, J. and Moll, W. (1976) The flow resistance of the material placental vascular bed of anesthetized guinea pigs. Z. Geburtshilfe. Perinatol. 180, 61–66.

    CAS  PubMed  Google Scholar 

  • Kastendieck, E., Kuenzel, W., and Kurz, C.S. (1980) Placental clearance of lactate and bicarbonate in sheep. Gynecol. Obstet. Invest. 10, 9–22.

    Article  Google Scholar 

  • Kastendieck, E. and Moll, W. (1977) The placental transfer of lactate and biocarbonate in the guinea-pig. Pflüegers Arch. 370, 165–171.

    Article  CAS  Google Scholar 

  • Kelman, B.J. (1977) Inorganic mercury movements across the perfused guinea pig placenta in late gestation. Toxicol. Appl. Pharmacol. 41, 659–665.

    Article  CAS  PubMed  Google Scholar 

  • Kelman, B.J. (1979) Effects of toxic agents on movements of materials across the placenta. Fed. Proc. 38, 2246–2250.

    CAS  PubMed  Google Scholar 

  • Kelman, B.J. and Sasser, L.B. (1977) Methylmercury movements across the perfused guinea pig placenta in late gestation. Toxicol. Appl. Pharmacol. 39, 119–127.

    Article  CAS  PubMed  Google Scholar 

  • Kelman, B.J. and Sikov, M.R. (1981) Plutonium movements across the hemochorial placenta of the guinea pig. Placenta 3, 319–326.

    CAS  PubMed  Google Scholar 

  • Kelman, B.J. and Springer, D.L. (1982) Movements of benzo(a)pyrene across the hemochorial placenta of the guinea pig. Proc. Soc. Exp. Biol. Med. 169, 58–62.

    Article  CAS  PubMed  Google Scholar 

  • Kelman, B.J. and Sikov, M.R. (1986) Effects of ultrasound on placental function. UFFC 2, 218–224.

    Article  Google Scholar 

  • Kelman, B.J. and Walter, B.K. (1977) Passage of cadmium across the perfused guinea pig placenta. Proc. Soc. Exp. Biol. Med. 156, 68–71.

    Article  CAS  PubMed  Google Scholar 

  • Kelman, B.J. and Walter, B.K. (1980a) Fetal to maternal cadmium movements across the perfused hemochorial placenta of the guinea pig. Toxicol. Appl. Pharmacol. 52, 440–406.

    Google Scholar 

  • Kelman, B.J. and Walter, B.K. (1980b) Transplacental movements of inorganic lead from mother to fetus. Proc. Soc. Exp. Biol. Med. 163, 278–282.

    Article  CAS  PubMed  Google Scholar 

  • Kilstrom, I. (1983) Placental transfer of diethylhexyl phathalate in the guinea-pig placenta perfused in situ. Acta Pharmacol. Toxicol. 53, 23–27.

    Article  Google Scholar 

  • Leichtweiss, H.P. and Schröder, H. (1971) Investigations of glucose transport across the isolated artificially perfused placenta of the guinea-pig. Pflüegers Arch. Eur. J. Physiol. 325, 139–148.

    Article  CAS  Google Scholar 

  • Leichtweiss, H.P. and Schröder, H. (1971) Glucose transport through the isolated, bilaterally artifically perfused placenta of the guinea pig. Arch Gynecol. 211, 146–147.

    CAS  Google Scholar 

  • McKercher, H.G., Derewlany, L.O., and Radde, I.C. (1982) Free calcium concentrations in Krebs-Ringer biocarbonate buffer: effects on 45Ca and 32P-transport across the perfused guinea pig placenta. Biochem. Biophys. Res. Comm. 105, 841–846.

    Article  CAS  PubMed  Google Scholar 

  • Moll, W. and Kastendieck, E. (1977) Transfor of N2O, CO and HTO in the artifically perfused guinea-pig placenta. Respir. Physiol. 29, 283–302.

    Article  CAS  PubMed  Google Scholar 

  • Nixon, D.A. (1972) Carbohydrate metabolism in fetal life. Phys. Biochem. of the Fetus Symposium XIV, 96–116.

    Google Scholar 

  • Nixon, D.A., Alexander, D.P., and Hugget, A.S. (1966) Influence of umbilical blood fructose on the production of fructose by the perfused placenta of sheep. Nature (Lond). 209, 918–919.

    Article  CAS  Google Scholar 

  • Powers, G.G. and Jenkins, F. (1975) Factors affecting 02 transfer in sheep and rabbit placenta perfused in situ. Am. J. Physiol. 229, 1147–1153.

    Google Scholar 

  • Reynolds, M. and Young, M. (1968) Transfer of amino-acids across the guinea-pig placenta perfused in situ. Proc. Int. Union Physiol. Sci. 7, 365.

    Google Scholar 

  • Rubio, V., Tan, C.B., Andrews, W.H., Nixon, D.A., Alexander, D.P., and Britton, H.G. (1983) Nitrogen metabolism in the sheep fetus. Observations on the liver and placenta. Biol. Neonate 43, 86–91.

    Article  CAS  PubMed  Google Scholar 

  • Schröder, H. and Leichtweiss, H.P. (1977) Perfusion rates and the transfer of water across isolated guinea pig placenta. Am. J. Physiol. 232, 666–670.

    Google Scholar 

  • Schröder, H., Paul, W., and Leichtweiss, H.P. (1981) Vascular volumes in isolated perfused guinea pig placenta. Am. Physiol. Soc. 241, H73 - H77.

    Google Scholar 

  • Schröder, H., Stolp,W., and Leichtweiss, H.P. (1972) Measurements of Na+ transport in the isolated, artificially perfused guinea pig placenta. Am. J. Obstet. Gynecol. 114, 51–57.

    PubMed  Google Scholar 

  • Sibley, C.P., Bauman, K.F., and Firth, J.A. (1981) Ultrastructural study of the permeability of the guinea-pig placenta to horseradish peroxidase. Cell Tissue Res. 219, 637–647.

    CAS  PubMed  Google Scholar 

  • Stulc, J. and Svihovec, B. (1979) Lack of effect of ouabain on sodium transport across the rat placenta. Pfliiegers Arch. 381, 79–81.

    Article  CAS  Google Scholar 

  • Stulc, J. and Svihovec, B. (1984) Transport of inorganic phosphate by the fetal border of the guinea-pig placenta perfused in situ. Placenta 5, 9–19.

    Article  CAS  PubMed  Google Scholar 

  • Stulc, J. and Svihovec, J. (1973) Effects of potassium cyanide, strophanthin or sodium-free perfusion fluid on the electrical potential difference across the guinea-pig placenta perfused in situ. J. Physiol. (Loud) 231, 403–415.

    CAS  Google Scholar 

  • Stulc, J. and Svihovec, J. (1977) Placental transport of sodium in the guinea-pig. J. Physiol. (Loud) 265, 691–703.

    CAS  Google Scholar 

  • Svihovec, J. and Stulc, J. (1972) Electrical potential difference between maternal and fetal side on the guinea pig placenta perfused in utero. Cesk. Fysiol. 21.

    Google Scholar 

  • Sweiry, J.H. and Yudilevich, D.L. (1984) Assymetric calcium influx and efflux at maternal and fetal sides of the guinea-pig placenta: Kinetics and specificity. J. Physiol. (Loud) 355, 295–311.

    CAS  Google Scholar 

  • Thomsen, K., Schniewind, H., Schultze-Mosgau, H., Kramer, M., and Born, H. (1967) Effect and passage of vasoactive drugs in the in vitro perfused placenta of guinea pigs. Arch. Gynecol. 204, 51–58.

    CAS  Google Scholar 

  • van Dijk, J.P. and van Kreel, B.K. (1978) Transport and accumulation of aaminoisobutyric acid (AIB) in the guinea pig placenta. P/lüegers Arch. 377, 217–224.

    Article  Google Scholar 

  • van Dijk, J.P. and van Kreel, B.K. (1982) Electric potential differences in the isolated guinea-pig placenta. J. Dew. Physiol. (Oxf.) 4, 23–28.

    Google Scholar 

  • van Dijk, J.P., van Kreel, B.K., and Heeren, J.W. (1985) Studies on the mechanisms involved in iron transfer across the isolated guinea pig placenta by means of bolus experiments. J. Dew. Physiol. (Oxf.) 7, 1–16.

    Google Scholar 

  • van Kreel, B.K. and van Dijk, J.P. (1977a) Transport of uric acid and hypoxanthine across the isolated guinea pig placenta. Biol. Neonate 32, 260–265.

    Article  PubMed  Google Scholar 

  • van Kreel, B.K. and van Dijk, J.P. (1977b) The influence of flow rates and flow distributions on diffusion controlled transport across the isolated guinea pig placenta. J. Comp. Physiol. B115, 255–264.

    Google Scholar 

  • Weatherley, A.J., Ross, R., Pickard, D.W., and Care, A.D. (1983) The transfer of calcium during perfusion of the placenta in intact and thyroparathyroidectomized sheep. Placenta 4, 271–278.

    Article  CAS  PubMed  Google Scholar 

  • Wong, C.T. and Morgan, E.H. (1973) Placental transfer of iron in the guinea pig. J. Exp. Physiol. 58, 47–58.

    CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Biology and Chemistry Department, Battelle Pacific Northwest Laboratories, Richland, Washington, 99352, USA

    Bruce J. Kelman

  2. Department of Chemical Pathology, Erasmus University, Rotterdam, 3000 Dr, The Netherlands

    Bernard K. van Kreel

Authors
  1. Bruce J. Kelman
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  2. Bernard K. van Kreel
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Editor information

Editors and Affiliations

  1. University of Rochester Medical Center, Rochester, New York, USA

    Richard K. Miller  & Henry A. Thiede  & 

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© 1987 Springer Science+Business Media New York

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Kelman, B.J., van Kreel, B.K. (1987). Criteria for Standardizing and Judging Viability Placental Perfusions in Animals. In: Miller, R.K., Thiede, H.A. (eds) Cellular Biology and Pharmacology of the Placenta. Trophoblast Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1936-9_36

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  • DOI: https://doi.org/10.1007/978-1-4757-1936-9_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1938-3

  • Online ISBN: 978-1-4757-1936-9

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