Skip to main content
SpringerLink
Log in

Placental Steroid Dehydrogenases: Assessment with a Nonhuman Primate in Situ Placental Perfusion Model

  • Chapter
Cellular Biology and Pharmacology of the Placenta

Part of the book series: Trophoblast Research ((TR))

  • 27 Accesses

Abstract

The oxidoreductase activity of 17β-hydroxysteroid dehydrogenase (17β-HSD) has been demonstrated in human placenta and catalyzes the interconversion of estradiol-17β (E2) and estrone (E1) (Langer and Engel, 1958; Jarabak and Sack, 1969; Strickler and Tobias, 1982). Preimplantation rat and mouse embryos have also been reported to possess 17β-HSD activity (Wu and Lin, 1982; Wu and Matsumoto, 1985). It has been postulated that 17β-HSD is responsible for the conversion of the potent estrogen, E2, to the less potent E1 in later-term non-human primate pregnancy (Slikker et al., 1982a) and regulates the ratio of E2 and E1 throughout the preimplantation period in the rodent (Wu and Matsumoto, 1985).

This work was presented in part at the 1984 Primatology Society Meetings.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Althaus, Z.R., Bailey, J.R., Leakey, J.E.A., and Slikker, W., Jr. (1986) Transplacental metabolism of dexamethasone and cortisol in the late gestational age monkey (Macaca mulatta). Develop. Pharmacol. Ther.,in press.

    Google Scholar 

  • Althaus, Z.R., Rowland, J.R., Freeman, P., and Slikker, W., Jr. (1982) Separation of some natural and synthetic corticosteroids by high performance liquid chromatography. J. Chromatog. 227 (1), 11–23.

    Article  CAS  Google Scholar 

  • Badawy, A.A.-B. and Evans, M. (1981) The mechanism of the antagonism by naloxone of acute alcohol intoxication. Br. J. Pharmacol. 74, 514–516.

    Article  CAS  PubMed  Google Scholar 

  • Berliner, D.L. and Ruhmann, A.G. (1969) Comparison of the growth of fibroblasts under the influence of 1 lß-hydroxy and 11-keto corticosteroids. Endocrinol. 78, 373–382.

    Article  Google Scholar 

  • Bernal, A.L., Flint, A.P.F., Anderson, A.B.M., and Turnbull, A.C. (1980) 1113hydroxysteroid dehydrogenase activity (E.C. 1.1.1.146) in human placenta and decidua. J. Steroid Biochem. 13, 1081–1087.

    Google Scholar 

  • Blomquist, C.H., Lindemann, N.J., and Hakanson, E.Y. (1984) Inhibition of 17ßhydroxysteroid dehydrogenase (17ß-HSD) activities of human placenta by steroids and non-steroidal hormone agonists and antagonists. Steroids 43 (5), 571–586.

    Article  CAS  PubMed  Google Scholar 

  • Hill, D.E., Slikker, W., Jr., Goad, P.T., Bailey, J.R., Szisazk, T.J., and Hendrickx, A.G. (1983) Maternal, fetal, and neonatal elimination of ethanol in nonhuman primates. Develop. Pharmacol. Ther. 6, 259–268.

    CAS  Google Scholar 

  • Jarabak, J. and Sack, G.H., Jr. (1969) A soluble 173-hydroxysteroid dehydrogenase from human placenta. The binding of pyridine nucleotides and steroids. Biochemistry 8, 2203–2211.

    Article  CAS  PubMed  Google Scholar 

  • Leakey, J.E.A., Althaus, Z.R., Bailey, J.R., and Slikker, W., Jr. (1985) Dexamethasone increases UDP-glucuronyltransferase activity towards bilirubin, oestradiol and testosterone in foetal liver from rhesus monkey during late gestation. Biochem. J. 225, 183–188.

    CAS  PubMed  Google Scholar 

  • Leakey, J.E.A., Althaus, Z.R., Bailey, J.R., and Slikker, W., Jr. (1986) Dexamethasone induces hepatic cytochrome P-450 content and increases certain monooxygenase activities in rhesus monkey foetuses. Biochem. Pharmacol. 35, 1389–1391.

    Article  CAS  PubMed  Google Scholar 

  • Murphy, B.E.P. (1979) Cortisol and cortisone in human fetal development. J. Steroid Biochem. 11, 509–513.

    Article  CAS  PubMed  Google Scholar 

  • Murphy, B.E.P., Sebenick, M., and Patchell, M.E. (1980) Cortisol production and metabolism in the human fetus and its reflection in the maternal urine. J. Steroid Biochem. 12, 37–45.

    Article  CAS  PubMed  Google Scholar 

  • Osinski, P.A. (1960) Steroid 110-ol dehydrogenase in human placenta. Nature 187, 777.

    Article  CAS  PubMed  Google Scholar 

  • Pares, X., Farres, J., and Vallee, B.L. (1984) Organ specific alcohol metabolism: Placental X-ADH. Biochem. Biophys. Res. Comm. 199 (3), 1047–1055.

    Article  Google Scholar 

  • Salaspuro, M.P., Shaw, S., Jayatilleke, E., Ross, W.A., and Lieber, C.S. (1981) Attenuation of the ethanol-induced hepatic redox change after chronic alcohol consumption in baboons: metabolic consequences in vivo and in vitro. Hepatol. 1 (1), 33–38.

    Article  CAS  Google Scholar 

  • Slikker, W., Jr., Lipe, G.W., and Newport, G.D. (1981) High-performance liquid chromatographic analysis of estradiol-170 and metabolites in biological media. J. Chromatog. 224 (2), 205–219.

    Article  CAS  Google Scholar 

  • Slikker, W., Jr., Hill, D.E., and Young, J.F. (1982a) Comparison of the transplacental pharmacokinetics of 1713-estradiol and diethylstilbestrol in the subhuman primate. J. Pharmacol. Exp. Ther. 221 (1), 173–182.

    CAS  PubMed  Google Scholar 

  • Slikker, W., Jr., Althaus, Z.R., Rowland, J.M., Hill, D.E., and Hendrickx, A.G. (1982b) Comparison of the transplacental pharmacokinetics of cortisol and triamcinolone acetonide in the rhesus monkey. J. Pharmacol. Exp. Ther. 223 (2), 368–374.

    CAS  PubMed  Google Scholar 

  • Slikker, W., Jr., Bailey, J.R., Newport, G.D., Lipe, G.W., and Hill, D.E. (1982c) Placental transfer and metabolism of 17a-ethynylestradiol-170 and estradiol170 in the rhesus monkey. J. Pharmacol. Exp. Ther. 223 (2), 483–489.

    CAS  PubMed  Google Scholar 

  • Slikker, W., Jr., Althaus, Z.R., Rowland, J.M., Hendrickx, A.G., and Hill, D.E. (1984a) Comparison of the metabolism of cortisol and triamcinolone acetonide in the early, mid and late gestation age rhesus monkey (Macaca mulatta). Develop. Pharmacol. Ther. 7, 319–333.

    CAS  Google Scholar 

  • Slikker, W., Jr., Lipe, G.W., Sziszak, J., and Bailey, J.R. (1984b) Changes in estrogen metabolism after chronic oral contraceptive administration in the rhesus monkey. Drug Metab. Dispos. 12 (2), 148–153.

    CAS  PubMed  Google Scholar 

  • Stolte, L.A.M. (1975) Pregnancy in the rhesus monkey. In: The Rhesus Monkey, vol. II, (ed.), G.W. Bourne, pp. 171–230.

    Google Scholar 

  • Strickler, R.C. and Tobias, B. (1982) 20a-hydroxysteroid dehydrogenase and 17ßestradiol dehydrogenase localize in cytosol of human term placenta. Am. J. Physiol. 242(3), 178–183.

    Google Scholar 

  • Wu, J.-T. and Lin, G.-M. (1982) The presence of 17f3-hydroxysteroid dehydrogenase activity in preimplantation rat and mouse blastocysts. J. Exp. Zool. 200, 121–124.

    Article  Google Scholar 

  • Wu, J.-T. and Matsumoto, P.S. (1985) Changing 17ß-hydroxysteroid dehydrogenase activity in preimplantation rat and mouse embryos. Biol. Reprod. 32, 561–566.

    Article  CAS  PubMed  Google Scholar 

  • Zahlten, R.N., Nejtek, M.E., and Jacobsen, C. (1982) Ethanol metabolism in guinea pig: ethanol oxidation and its effect on NAD/NADH ratios, oxygen consumption, and ketogenesis in isolated hepatocytes of fed and fasted animals. Arch. Biochem. Biophys. 213 (1), 200–231.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pharmacodynamics Branch, Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, 72079, USA

    William Slikker Jr., John R. Bailey, George W. Lipe, Zelda Althaus & Julian E. A. Leakey

  2. Department of Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA

    John R. Bailey, George W. Lipe, Zelda Althaus & Julian E. A. Leakey

Authors
  1. William Slikker Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John R. Bailey
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. George W. Lipe
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zelda Althaus
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Julian E. A. Leakey
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Rochester Medical Center, Rochester, New York, USA

    Richard K. Miller  & Henry A. Thiede  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer Science+Business Media New York

About this chapter

Cite this chapter

Slikker, W., Bailey, J.R., Lipe, G.W., Althaus, Z., Leakey, J.E.A. (1987). Placental Steroid Dehydrogenases: Assessment with a Nonhuman Primate in Situ Placental Perfusion Model. In: Miller, R.K., Thiede, H.A. (eds) Cellular Biology and Pharmacology of the Placenta. Trophoblast Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1936-9_33

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-1936-9_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1938-3

  • Online ISBN: 978-1-4757-1936-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation