Abstract
Although not widely appreciated, nuclear magnetic resonance (NMR) spectroscopy has been used as a research tool in obstetrics and gynecology for many years. Odeblad and colleagues have used NMR to characterize the structure of water in human vaginal cells (Odeblad, 1959), human milk (Odeblad and Westin, 1958), myometrium (Odeblad and Ingelman-Sundberg, 1965) and cervical mucus (Odeblad and Bryhn, 1957). Recently, with the growing availability of magnetic resonance imaging (MRI) units there has been an interest in exploring the technique in obstetrics (Smith et al., 1983; Johnson et al., 1984) and gynecology (Thickman et al., 1984). Indeed, a recent report suggests that MRI may be useful in prenatal evaluation of intrauterine growth retardation — by virtue of its ability to quantitate subcutaneous fat (Stark et al., 1985).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alger, J.R. and Shulman, R.G. (1984) Metabolic application of high-resolution 13C nuclear magnetic resonance spectroscopy. Br. Med. Bull. 40, 160–164.
Beall, P.T., Amtey, S.R., and Kasturi, S.R. (1984) NMR Data Handbook for Biomedical Applications, Pergamon Press, New York, pp. 101–153.
Behar, K.L., DenHollander, J.A., Stromshi, M.E., Ogino, T., Shulman, R.G., Petroff, O.A.C., and Prichard, J.W. (1983) High resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo. Proc. Natl. Acad. Sci. USA 80, 4945–4948.
Bene, G.J., Borcard, B., Graf, V., Hiltbrand, E., Magnin, P., and Noach, F. (1982) Proton NMR-relaxation dispersion in meconium solutions and healthy amniotic fluid: possible applications to medical diagnosis. Z. Naturforsch 37, 394–398.
Bock, J.L. (1985) Recent developments in biochemical nuclear magnetic resonance spectroscopy. Methods Bioch. Analy. 31, 259–315.
Borcard, B., Hiltbrand, E., Magnin, P., Rone, G.J., Briguet, A., Duplan, J.C., Delman, J., Guibaud, S., Bonnet, M., Dumont, M., and Fara, J.F. (1982) Estimating meconium (fetal feces) concentration in human amniotic fluid by nuclear magnetic resonance. Physiol. Chem. Phy. 14, 189–192.
Cady, E.B., Costello, A.M., Dawson, M.J., Delpy, D.T., Hope, P.L., Reynolds, E.O.R., Tofts, P.S., and Wilkie, D.R. (1983) Non-invasive investigation of cerebral metabolism in newborn infants by phosphorous nuclear magnetic resonance spectroscopy. Lancet 1, 1059–1062.
Cohen, J.S., Knop, R.H., Navon, G., and Foxall, D. (1983) Nuclear magnetic resonance in biology and medicine. Life Chem. Rep. 1, 281–457.
Damadian, R. (1981) NMR in Medicine, Springer-Verlag, New York.
Foster, M.A. (1984) Magnetic Resonance in Biology and Medicine, Pergamon Press, New York.
Fukushima, E. and Roeder, S.B.W. (1981) Experimental Pulse NMR. A Nuts and Bolts Approach. Addison-Wesley, Reading, MA.
Gadian, D.G. (1982) Nuclear Magnetic Resonance and its Applications to Living Systems. Oxford University Press, New York.
Gore, J.C. and Smith, F.W. (1985) Contrast Agents. Magnetic Resonance Imaging 3, 1–97.
Johnson, I.R., Symond, E.M., Kean, D.M., Worthington, B.S., Broughton, Pipkin, F., Hawkes, R.C., and Gyngell, M. (1984) Imaging the pregnant human uterus with nuclear magnetic resonance. Am. J. Obstet. Gynecol. 148, 1136–1139.
Kay, H.H. and Mattison, D.R. (1986) Magnetic Resonance Imaging in Nonhuman Primates. In: Animals in Perinatal Research,(ed.), P.W. Nathanielsz, in press.
Maudsley, A.A. and Hilal, S.K. (1984) Biological aspects of sodium-23 imaging. Br. Med. Bull. 40, 165–166.
Meis, P.J., Hall, M., Marshall, J.R., and Hobel, C.J. (1978) Meconium passage: a new classification for risk assessment during labor. Am. J. Obstet. Gynecol. 131, 509–513.
Mitchell, M.R., Conturo, T.E., Gruber, T.J., and Jones, J.P. (1984) Two computer models for selection of optimal magnetic resonance imaging (MRI) pulse sequence timing. Invest. Radiol. 19, 350–360.
Moore, W.S. (1984) Basic physics and relaxation mechanisms. Br. Med. Bull. 40, 120–125
Odeblad, E. (1959) Studies on vaginal contents and cells with proton magnetic resonance. Ann. NY Acad. Sci. 3, 189–206.
Odeblad, E. and Bryhn, U. (1957) Proton magnetic resonance of human cervical mucus during the menstrual cycle. Acta Radiol. 47, 315–320.
Odeblad, E. and Ingelman-Sundberg, A. (1965) Proton magnetic resonance studies on the structure of water in the myometrium. Acta Obstet. Gynec. Scand. 44, 117–120
Odeblad, E. and Westin, B. (1958) Proton magnetic resonance of human milk. Acta Radiologica 49, 389–392.
Partain, C.L., James, A.E., Rollo, F.D., and Price, R.R. (eds.) (1983) Nuclear Magnetic Resonance (NMR) Imaging, Saunders, Philadelphia.
Pople, J.A., Schneider, W.G., and Bernstein, H.J. (1959) High Resolution Nuclear Magnetic Resonance, McGraw-Hill, New York.
Prichard, J.W., Alger, J.R., Behar, K.L., Petroff, O.A.C., and Shulman, R.G. (1983) Cerebral metabolic studies in vivo by 3113 NMR. Proc. Natl. Acad. Sci. USA 80, 2748–2751.
Radda, G.K., Bore, P.J., and Rajagopalan, B. (1984) Clinical aspects of 3113 NMR spectroscopy. Br. Med. Bull. 40, 155–159.
Smith, F.W., Adams, A., and Phillips, W.P. (1983) NMR imaging in pregnancy. Lancet 1, 61–62.
Stark, D.D., Hricak, H., and Paver, J.T. (1985) Intrauterine growth retardation: evaluation by magnetic resonance. Radiol. 155, 425–427.
Steiner, R.E. and Radda, G.K. (1984) Nuclear magnetic resonance and its clinical applications. Br. Med. Bull. 40, 113–206.
Thickman, D., Kressel, H., Gussman, D., Axel, L., and Hogan, M. (1984) Nuclear magnetic resonance imaging in gynecology. Am. J. Obstet. Gynecol. 149, 835–840.
Weisman, I.D., Bennett, L.H., Maxwell, L.R., and Henson, D.E. (1981) Cancer detection by NMR in the living animal. In: NMR in Medicine, (ed.), R. Damadian, Springer-Verlag, New York, pp. 17–37.
Wolf, G.L. (1984) Contrast enhancement in biomedical NMR: A symposium. Physiol. Chem. Phys. Med. NMR 16, 89–172.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer Science+Business Media New York
About this chapter
Cite this chapter
Thomford, P.J., Jordan, J., Angtuaco, T., Cockrill, H.H., Mattison, D.R. (1987). Characterization of Magnetic Resonance Parameters in the Pregnant Uterus. In: Miller, R.K., Thiede, H.A. (eds) Cellular Biology and Pharmacology of the Placenta. Trophoblast Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1936-9_27
Download citation
DOI: https://doi.org/10.1007/978-1-4757-1936-9_27
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-1938-3
Online ISBN: 978-1-4757-1936-9
eBook Packages: Springer Book Archive