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Cellular Biology and Pharmacology of the Placenta pp 289–304Cite as

Regional and Differential Sensitivity of Umbilico-Placental Vasculature to 5-Hydroxytryptamine, Nicotine, and Ethyl Alcohol

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Part of the book series: Trophoblast Research ((TR))

Abstract

The fetal blood concentration of 5-hydroxytryptamine (5-HT) increases before birth (Jones and Rowsell, 1973). 5-HT decreases perfusion flow through umbilicoplacental vasculature in isolated human placenta (Gautieri and Ciuchta, 1962). Nicotine is known to release 5-HT from nervous tissues (Goodman and Weiss, 1973; Balfour, 1973; Hery et al., 1977). Among tobacco smokers, nicotine enters fetal circulation from maternal blood. Therefore, a question arises as to whether nictoine releases 5-HT which decreases fetal blood flow through placenta and contributes to fetal hypoxia and growth retardation in tobacco smokers.

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Authors and Affiliations

  1. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232, USA

    B. V. Rama Sastry & L. K. Owens

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  1. B. V. Rama Sastry
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  2. L. K. Owens
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Editors and Affiliations

  1. University of Rochester Medical Center, Rochester, New York, USA

    Richard K. Miller  & Henry A. Thiede  & 

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© 1987 Springer Science+Business Media New York

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Sastry, B.V.R., Owens, L.K. (1987). Regional and Differential Sensitivity of Umbilico-Placental Vasculature to 5-Hydroxytryptamine, Nicotine, and Ethyl Alcohol. In: Miller, R.K., Thiede, H.A. (eds) Cellular Biology and Pharmacology of the Placenta. Trophoblast Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1936-9_21

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  • DOI: https://doi.org/10.1007/978-1-4757-1936-9_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1938-3

  • Online ISBN: 978-1-4757-1936-9

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