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Cellular Biology and Pharmacology of the Placenta pp 3–15Cite as

Biochemical and Immunological Aspects of the Human Trophoblast Cell Surface

A Review

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Part of the book series: Trophoblast Research ((TR))

Abstract

Following blastocyst implantation, the outer layer of human trophoblast rapidly proliferates and several anatomically distinct populations of trophoblast develop in the placenta and extraembryonic membranes as gestation progresses (Hertig et al., 1954; Boyd and Hamilton, 1970; Bulmer and Johnson, 1985). The major trophoblast population covers chorionic villi (or conversely lines intervillous spaces) and is therefore in intimate contact with maternal blood. This villous trophoblast layer is organized into an inner cytotrophoblast and an outer syncytiotrophoblast layer with numerous microvilli on the maternal-facing surface. Also of relevance to this review is extravillous cytotrophoblast which proliferates into maternal uterine tissue from the implantation site. Since high purity preparations of syncytiotrophoblast surface microvillous plasma membrance (StMPM) can be readily obtained from term placentae (Smith et al., 1974; Ogbimi et al., 1979), the majority of biochemical and immunological studies have centered on syncytiotrophoblast.

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Authors and Affiliations

  1. Pregnancy Immunology Group Department of Immunology, University of Liverpool, PO Box 147, Liverpool, L69 3BX, UK

    Paul D. Webb, Nicholas Hole, P. Jeremy McLaughlin, Peter L. Stern & Professor Peter M. Johnson

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  1. Paul D. Webb
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  2. Nicholas Hole
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  3. P. Jeremy McLaughlin
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  4. Peter L. Stern
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  1. University of Rochester Medical Center, Rochester, New York, USA

    Richard K. Miller  & Henry A. Thiede  & 

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Webb, P.D., Hole, N., McLaughlin, P.J., Stern, P.L., Johnson, P.M. (1987). Biochemical and Immunological Aspects of the Human Trophoblast Cell Surface. In: Miller, R.K., Thiede, H.A. (eds) Cellular Biology and Pharmacology of the Placenta. Trophoblast Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1936-9_1

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  • DOI: https://doi.org/10.1007/978-1-4757-1936-9_1

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