Abstract
A number of epidemiologic and angiographic studies have established that the risk of developing ischemic heart disease (IHD) and the extent of coronary atherosclerosis bear a direct relationship to plasma LDL cholesterol concentration but are inversely correlated to HDL cholesterol.1,2 The latter association seems to be mostly mediated by the HDL2 subfraction.3 The question on the possible additional role of elevated plasma triglyceride and VLDL levels in increasing the risk of IHD has remained controversial.4 Many authors agree that hypertriglyceridemia is common among patients with IHD and alsopredicts the risk of developing new IHD5, 6 but multivariate HDL analyses considering also plasma HDL have consistently eliminated triglycerides as an independent risk factor.4 In other words, elevated VLDL indicates an increased risk of IHD only because of its close inverse association with HDL. Thus, high VLDL is not atherogenic if not accompanied by low HDL. It is also evident that the significance of HDL as a protective factor of IHD increases with increasing LDL cholesterol concentration. Accordingly, among populations with low LDL levels (usually due to diet) a simultaneous low HDL cholesterol is not atherogenic.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
G. J. Miller, The epidemiology of plasma lipoproteins and atherosclerotic disease, in: “Lipoproteins, Atherosclerosis and Coronary Heart Disease,” N. E. Miller and B. Lewis, eds., Elsevier/North Holland, Biomedical Press (1981).
N. E. Miller, Coronary atherosclerosis and plasma lipoproteins: Epidemiology and pathophysiology considerations, J.Cardiovasc. Pharmacol. 4: suppl. 2:190 (1982).
N. E. Miller, F. Hammet, S. Rao, H. van Zeller, J. Coltart, and B. Lewis, Relation of angiographically defined coronary artery disease to plasma lipoprotein subfractions and apolipoproteins, Br.Med.J. 282:1741 (1981).
K. Lippel, H. Tyroler, H. Eder, A. Gotto Jr., and G. Vahouny, Relationship of hypertriglyceridemia to atherosclerosis, Arteriosclerosis 1:406 (1981).
L. A. Carlson, L. E. Böttiger, and P. -E. Åhfeldt, Risk factors for myocardial infarction in the Stockholm Prospective Study, Acta Med.Scand. 206:351 (1979).
R. Pelkonen, E. A. Nikkilä, S. Koskinen, K. Penttinen, and S. Sarna, Association of serum lipids and obesity with cardiovascular mortality, Br.Med.J. 2:1185 (1977).
C. J. Fielding and P. E. Fielding, Evidence for a lipoprotein carrier in human plasma catalyzing sterol efflux from cultured fibroblasts, and its relationship to lecithin: cholesterol acyltransferase activity, Proc. Natl.Acad.Sci.USA 78:3911 (1981).
J. R. Patsch, A. M. Gotto Jr., T. Olivecrona, and S. Eisenberg, Formation of high density lipoprotein-like particles during lipolysis of very low density lipoproteins in vitro, Proc. Natl.Acad. Sci.USA 75: 4519 (1978).
N. E. Miller, S. N. Rao, P. Alaupovic, N. Noble, L. Slack, J. Brunzell, and B. Lewis, Familial apolipoprotein C II deficiency: Plasma lipoproteins and apolipoproteins in heterozygous and homozygous subjects and the effects of plasma infusion, Eur.J.Clin.Invest. 11:69 (1981).
E. A. Nikkilä, M. -R. Taskinen, and M. Kekki, Relation of plasma high-density lipoprotein cholesterol to lipoprotein lipase activity in adipose tissue and skeletal muscle of man, Atherosclerosis 29:497 (1978).
M. -R. Taskinen and E. A. Nikkilä, High density lipoprotein subfractions in relation to lipoprotein lipase activity of tissues in man — evidence for reciprocal regulation of HDL2 and HDL3 levels by lipoprotein lipase, Clin.Chim.Acta 112: 325 (1981).
E. A. Nikkilä, M. -R. Taskinen, S. Rehunen, and M. Härkönen, Lipoprotein lipase activity in adipose tissue and skeletal muscle of runners: Relation to serum lipoproteins, Metabolism 27:1661 (1978).
P. D. Wood and W. L. Haskell, The effect of exercise on plasma high density lipoproteins, Lipids 14:417 (1979).
E. A. Nikkilä, T. Kuusi, and P. Myllynen, High density lipoprotein and apolipoprotein A-I during physical inactivity: Demonstration of low levels in patients with spine fracture, Atherosclerosis 37:457 (1980).
T. Kuusi, P. K. J. Kinnunen, and E. A. Nikkilä, Hepatic endothelial lipase antiserum influences rat plasma low and high density lipoproteins in vivo, FEBS Lett. 104:384 (1979).
A. van Tol, T. van Gent, and H. Jansen, Degradation of high density lipoprotein by heparin-releasable liver lipase, Biochem.Biophys.Res.Commun. 94:101 (1980).
K. Shirai, R. L. Barnhart, and R. L. Jackson, Hydrolysis of human plasma high density lipoprotein2-phospholipids and triglycerides by hepatic lipase, Biochem.Biophys.Res.Commun. 100:591 (1981).
T. Kuusi, P. Saarinen, and E. A. Nikkilä, Evidence for the role of hepatic endothelial lipase in the metabolism of plasma high density lipoprotein2 in man, Atherosclerosis 36:589 (1980).
M. J. Tikkanen, E. A. Nikkilä, T. Kuusi, and S. Sipinen, Different effects of two progestins on plasma high density lipoprotein (HDL2) and postheparin plasma hepatic lipase activity, Atherosclerosis 40:365 (1981).
C. Ehnholm, J. K. Huttunen, P. K. Kinnunen, T. A. Miettinen, and E. A. Nikkilä, Effect of oxandrolone treatment on the activity of lipoprotein lipase, hepatic lipase and phospholipase Al of postheparin human plasma, N.Engl.J.Med. 292:1314 (1975).
T. Tamai, T. Nakai, S. Yamada, T. Kobayashi, T. Hayashi, Y. Kutsumi, and R. Takeda, Effects of oxandrolone on plasma lipoproteins in patients with type IIa, IIb and IV hyperlipoproteinemia: Occurrence of hypo-high density lipoproteinemia, Artery 5:125 (1979).
E. A. Nikkilä, T. Kuusi, and M. -R. Taskinen, Role of lipoprotein lipase and hepatic endothelial lipase in the metabolism of high density lipoproteins: A novel concept on cholesterol transport in HDL cycle, in: “Metabolic Risk Factor in Ischemic Cardiovascular Disease,” L. A. Carlson, and B. Pernow, eds., Raven Press, New York (1982).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer Science+Business Media New York
About this chapter
Cite this chapter
Nikkilä, E.A. (1984). Regulation of Plasma High Density Lipoprotein Concentration by Lipoprotein Lipase and Hepatic Endothelial Lipase. In: Chazov, E.I., Smirnov, V.N., Oganov, R.G. (eds) Cardiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1824-9_32
Download citation
DOI: https://doi.org/10.1007/978-1-4757-1824-9_32
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-1826-3
Online ISBN: 978-1-4757-1824-9
eBook Packages: Springer Book Archive