Abstract
Although it is now nearly half a century since Goldblatt and his colleagues demonstrated that hypertension could be produced experimentally by the application of a constriction to a renal artery,1 the pathogenesis of this condition remains imperfectly understood. The issue is clinically relevant, because in man hypertension is often associated with renal artery stenosis, and in a proportion of such patients, although by no means all, blood pressure can be lowered either by renal arterial reconstruction or by excision of the kidney distal to the stenosis. The importance of the renin-angiotensin system in initiating and maintaining renovascular hypertension remains particularly controversial.
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Brown, J.J. et al. (1984). Renovascular Hypertension: New Aspects of Pathogenesis and Treatment. In: Chazov, E.I., Smirnov, V.N., Oganov, R.G. (eds) Cardiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1824-9_29
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DOI: https://doi.org/10.1007/978-1-4757-1824-9_29
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