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Control and Treatment of Arterial Hypertension

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Cardiology
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Abstract

Control of hypertension can be interpreted in two ways. According to the WHO Technical Report “Arterial Hypertension” (1978), “the term ‘hypertension control’ includes all measures for health protection and promotion related to high blood pressure”, and “control programs” refer to public health actions aimed at hypertension control. The other meaning applies to the efficacy of therapy in the sense that high blood pressure of the patient should be kept under control. In other words, aspects of community programs of hypertension and of individual antihypertensive treatment have to be considered when we speak of hypertension control. This lecture will mainly deal with effective drug treatment of high blood pressure. However, in view of the large number of subjects who have elevated blood-pressure levels and the possible public health and economic consequences that may arise if drug therapy is generally recommended, it is advisable to discuss, at the beginning, some of the large controlled studies in which the significance of effective blood-pressure control for the community was investigated.

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References

  • Amery, A., and De Schaepdryver, A., 1981, Antihypertensive therapy in patients above age 60. Fifth interim report of the European Working Party on High Blood Pressure in the Elderly (EWPHE). Current Concepts in Hypertension and Cardiovascular Disorders, 2:14–20.

    Google Scholar 

  • Anavekar, S. N., Ludbrooke, A., Louis, W. J., and Doyle, A. E., 1979, Evaluation of indapamide in the treatment of hypertension, J.Cardiovasc.Pharmacol., 1:389–394.

    Article  PubMed  CAS  Google Scholar 

  • Andrews, G., Macmahon, S. W., Austin, A., and Byrne, D. G., 1982 Hypertension: Comparison of drug and non-drug treatments, Brit.Med.J., 284: 1523–26.

    Article  CAS  Google Scholar 

  • Atkinson, A. B., Lever, A. F., Brown, J. J., and Robertson, J. I. S., Combined treatment of severe intractable hypertension with Captopril and diuretic, Lancet 1980/11, 105–107.

    Article  Google Scholar 

  • Australian National Blood Pressure Study Management Committee, The Australian therapeutic trial in mild hypertension, Lancet 1980/1, 1261–1267.

    Google Scholar 

  • Bauer, G. E., and Hunyor, S. N., 1978, Mild hypertension: Is treatment worthwhile? Drugs, 15:80–86.

    Article  PubMed  CAS  Google Scholar 

  • Bolli, P., Amann, F. W., and Bühler, F. R., 1980, Antihypertensive response to postsynaptic a-blockade with prazosin in low- and normal-renin hypertension, J.Cardiovasc.Pharmacol., 2:Suppl.3, 399–405.

    Article  Google Scholar 

  • Brogden, R. N., Heel, R. C., Speight, T. M., and Avery, G. S., 1977, Prazosin: A review of its pharmacological properties and therapeutic efficacy in hypertension, Drugs, 14:163–197.

    Article  PubMed  CAS  Google Scholar 

  • Bühler, F. R., Laragh, J. H., Baer, L., Vaughan, E. D., Jr., and Brunner, H. R., 1972, Propranolol inhibition of renin secretion. A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases, New Engl.J.Med., 287: 1209–1214.

    Article  PubMed  Google Scholar 

  • Bühler, F. R., Hulthén, U. L., Kiowski, W., Müller, F., and Bolli, P., 1982, The place of the calcium antagonist verapamil in antihypertensive therapy, J.Cardiovasc.Pharmacol., 4:Suppl.3, in press.

    Google Scholar 

  • Bulpitt, C. J., Daymond, M. J., and Dollery, C. T., 1982, Community care compared with hospital outpatient care for hypertensive patients, Brit.Med.J., 284:554–556.

    Article  CAS  Google Scholar 

  • DeCree, J., Verhaegen, H., and Symoens, J., Acute blood pressure lowering effect of ketanserin, Lancet 1981/1, 1161–1162.

    Article  CAS  Google Scholar 

  • Day, J. L., Metcalfe, J., and Simpson, C. N., 1982, Adrenergic mechanisms in control of plasma lipid concentrations, Brit.Med.J., 284:1145–1148.

    Article  CAS  Google Scholar 

  • Fozard, J. R., The hypotensive effect of ketanserin in anaesthetized normotensive rats, Proc.Brit.Pharmacol.Soc., December 1981, Abstracts, P 63.

    Google Scholar 

  • Gross, F., 1982a, Present concepts and perspectives of antihypertensive therapy, Clin.Exp.Hypertension, A4:1–25.

    Article  Google Scholar 

  • Gross, F., 1982b, The place of a-adrenoceptor and ß-adrenoceptor blockade in the treatment of hypertension, Brit.J.Clin.Pharmacol., 13:Suppl.l, 5–11.

    Article  CAS  Google Scholar 

  • Helgeland, A., 1980, Treatment of mild hypertension: A five year controlled drug trial. The Oslo study, Am.J.Med., 69:725–732.

    Article  PubMed  CAS  Google Scholar 

  • Hulthén, U. L., Bolli, P., Amann, S. W., Kiowski, W., and Bühler, F. R., 1982, Enhanced vasodilatation in essential hypertension by calcium-channel blockade with verapamil, Hypertension, 4: Suppl., 26–31.

    PubMed  Google Scholar 

  • Hypertension Detection and Follow-up Program Cooperative Group, 1979, Five-year findings of the hypertension detection and follow-up program, I. Reduction in mortality of persons with high blood pressure, including mild hypertension, J.Am.Med.Assoc., 242:2562–2571.

    Article  Google Scholar 

  • Krebs, R., Graefe, K. -H., and Ziegler, R., 1982, Effects of calcium-entry antagonists in hypertension, Clin.Exp.Hypertension, A4:271–284.

    Article  Google Scholar 

  • Ledingham, J. G. G., and Rajagopalan, B., 1979, Cerebral complications in the treatment of accelerated hypertension, Quart.J.Med., (N.S.) 48:25–41.

    CAS  Google Scholar 

  • Leonetti, G., Pasotti, C., Ferrari, G. P., and Zanchetti, A., 1981, Double-blind comparison of the antihypertensive effects of verapamil and propranolol, in: “Calcium Antagonism in Cardiovascular Therapy.” Internat. Symp. Florence, October 1980, A. Zanchetti and D. M. Krikler, eds., Excerpta Medica, Amsterdam-Oxford-Princeton, p. 260–267.

    Google Scholar 

  • Leren, P., Foss, P. O., Helgeland, A., Hjermann, I., Holme, I., and Lund-Larsen, P. G., 1980, Effect of propranolol and Prazosin on blood lipids, Lancet 2:4–6.

    Article  PubMed  CAS  Google Scholar 

  • Lowe, J., Gray, J., Henry, D. A., and Lawson, D. H., 1979, Adverse reactions to frusemide in hospital inpatients, Brit.Med.J., 2:360–362.

    Article  PubMed  CAS  Google Scholar 

  • MacGregor, G. A., Markandu, N. D., Banks, R. A., Bayliss, J., Roulston, J. E., and Jones, J. C., 1982, Captopril in essential hypertension: contrasting effects of adding hydrochlorothiazide or propranolol, Brit.Med.J., 284:693–696.

    Article  CAS  Google Scholar 

  • McFate Smith, W., Edlavitch, S. A., and Krushar, W. M., 1979, U.S. Public Health Service hospitals intervention trial in mild hypertension, in: “Hypertension — Determinants, Complications and Intervention,” G. Onesti and C. R. Klimt, eds., Grune and Stratton, New York, p. 381–399.

    Google Scholar 

  • Morgan, T., 1976, Beta-adrenoceptor blocking drugs in the treatment of hypertension, Australia and New Zealand Journal of Medicine, 6:612.

    Google Scholar 

  • Morgan, T., Adam, W. R., Hodgson, M., and Myers, J., 1979, Duration of effect of different diuretics, Medical Journal of Australia, 2:315–316.

    PubMed  CAS  Google Scholar 

  • M.R.C. Working Party on Mild to Moderate Hypertension, Adverse reactions to bendrofluazide and propranolol used in the treatment of mild hypertension, Lancet 1981/11, 539–543.

    Google Scholar 

  • Muiesan, G., Agabiti-RoSci, E., Alicandri, C., Beschi, M., Castellano, M., Corea, L., Fariello, R., Romanelli, G., Pasini, C., and Platto, L., 1981, Influence of verapamil on catecholamines, renin and aldosterone in essential hypertensive patients, in: “Calcium Antagonism in Cardiovascular Therapy,” Internat. Symp. Florence, October 1980, A. Zanchetti and D. M. Krikler, eds., Excerpta Medica, Amsterdam-Oxford-Princeton, p. 238–249.

    Google Scholar 

  • Van Nueten, J. M., Janssen, P. A. J., Van Beek, J., Xhonneur, R., Verbeuren, T. J., and Vanhoutte, P. M., 1981, Vascular effects of R 41.468, a novel antagonist of 5-HT serotonergic receptors, J.Pharmacol.Exp.Ther., 218:217–230.

    PubMed  Google Scholar 

  • Passeron, J., Pauly, N., and Desprat, J., 1981, International multi-center study of indapamide in the treatment of essential arterial hypertension, Postgrad.Med.J., 57:Suppl,2, 57–59.

    Article  PubMed  Google Scholar 

  • Patel, C., 1975a, Yoga and biofeedback in the management of ‘stress’ in hypertensive patients, Clin.Sci.Mol.Med., 48:Suppl.2, 171–174.

    Google Scholar 

  • Patel, C., 12-month follow-up of yoga and bio-feedback in the management of hypertension, Lancet 1975b/l, 62–65.

    Article  Google Scholar 

  • Prichard, B. N. C., and Richards, D. A., 1982, Comparison of labetalol with other anti-hypertensive drugs, Brit,J.Clin.Pharmacol., 13:Suppl.l, 41–47.

    Article  CAS  Google Scholar 

  • Report on Round Table, 1975, On renin suppression and the hypotensive action of beta-adrenergic-blocking drugs, Clin.Sci.Mol.Med., 48:Suppl.2, 109–115.

    Google Scholar 

  • Report of a WHO Expert Committee, 1978, Arterial Hypertension, Technical Report Series No.628, World Health Organization, Geneva.

    Google Scholar 

  • Report by the Management Committee of the Australian Therapeutic Trial in Mild Hypertension, Untreated mild hypertension, Lancet 1982/1, 185–191.

    Google Scholar 

  • Rose, G., 1981, Strategy of prevention: lessons from cardiovascular disease, Brit.Med.J., 282:1847–1851.

    Article  CAS  Google Scholar 

  • Swales, J. D., Bing, R. F., Heagerty, A., Pohl, J. E. F., Russell, G. I., and Thurston, H., Treatment of refractory hypertension, Lancet 1982/1, 894–896.

    Article  PubMed  CAS  Google Scholar 

  • Tenschert, W., Studer, A., Záruba, K., Reuteler, H., Siebenschein, R., Siegenthaler, W., and Vetter, W., 1980, Minoxidil in hypertension, in: “Symposium: Clinical Pharmacology of Antihypertensive Agents.” K. H. Rahn and H. A. J. Struyker-Boudier, eds., Arch. Int. Pharmacodyn. Ther., p.104–115.

    Google Scholar 

  • Turner, P., Volans, N. G., and Rogers, H. J., 1977, Initial controlled evaluation of antihypertensive drugs: a study with indapamid, Curr.Med.Res.Opin., 5:Suppl.l, 124–128.

    Article  Google Scholar 

  • Veterans Administration Cooperative Study Group on Antihypertensive Agents, 1967, Effects of treatment on morbidity in hypertension: Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg, J.Am.Med.Assoc., 202:1028–1034.

    Article  Google Scholar 

  • Veterans Administration Cooperative Study Group on Antihypertensive Agents, 1970, Effects of treatment on morbidity in hypertension II, Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg, J.Am.Med.Assoc., 213:1143–1152.

    Article  Google Scholar 

  • Waal-Manning, H. J., 1976, Hypertension: Which beta-blocker? Drugs 12:412–441.

    Article  PubMed  CAS  Google Scholar 

  • Wenting, G. J., Manin’t Veld, A. J., Woittiez, A. J., Boomsma, F., Schalekamp, M. A. D. H., 1982, Treatment of hypertension with ketanserin, a new selective 5-HÏ2 receptor antagonist, Clin. Res., 284:537–539.

    CAS  Google Scholar 

  • Wheeley, M. St. G., Bolton, J. C., and Campbell, D. B., 1982, Indapamide in hypertension: a study in general practice of new or previously poorly controlled patients, Pharmathera-peutica 2:143–152.

    Google Scholar 

  • White, N. J., Yahaya, H., Rajagopalan, B., and Ledingham, J. G. G., Captopril and frusemide in severe drug-resistant hypertension, Lancet 1980/11, 108–110.

    Article  Google Scholar 

  • Withworth, J. A., and Kiticaid-Smith, P., 1982, Diuretics or 3-blockers first for hypertension? Drugs 23:394–402.

    Article  Google Scholar 

  • W.H.O./I.S.H. Mild Hypertension Liaison Committee, Trials of the treatment of mild hypertension, An Interim Analysis, Lancet 1982/1, 149–156.

    Google Scholar 

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Gross, F. (1984). Control and Treatment of Arterial Hypertension. In: Chazov, E.I., Smirnov, V.N., Oganov, R.G. (eds) Cardiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1824-9_2

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  • DOI: https://doi.org/10.1007/978-1-4757-1824-9_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1826-3

  • Online ISBN: 978-1-4757-1824-9

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