Abstract
The regression of atherosclerosis in various animal species has been reviewed by several investigators.1–4 The study of this phenomenon in nonhuman primates stemmed from the observations of Armstrong et al. in rhesus macaques (Macaca mulatta).5 They demonstrated that in advanced coronary atherosclerotic lesions induced by a high-cholesterol diet there is a remarkable decrease in lumen stenosis when the animals are shifted to a low-cholesterol diet. Their observations have been confirmed in the same species by Clarkson et al.,6 Stary,7 Eggen et al.,8 and Wissler,9 and have been extended to cynomolgus macaques (Macaca fascicularis) by others.10–12
This work has been carried out with the collaboration of P. McLaughlin, A. L. Livingston, G. O. Kohler, W. P. McNulty, and H. C. Stary. Publication No. 1274 of the Oregon Regional Primate Research Center, partially supported by grants RR-00163 and HL-16587 of the National Institutes of Health.
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Malinow, M.R. (1984). Plant Glycosides: Effects on Atherosclerosis Regression in Macaca Fascicularis . In: Malinow, M.R., Blaton, V.H. (eds) Regression of Atherosclerotic Lesions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1773-0_6
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