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Membrane Physiology pp 357–367Cite as

Genes and Membranes

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Abstract

It is now generally accepted that the composition of biological membranes is under genetic control. For each membrane protein, each enzyme involved in the biosynthesis of membrane lipids, and each enzyme that modifies either proteins or lipids (e.g., by adding carbohydrate residues to make glycoproteins or glycolipids), there must be a structural gene whose nucleotide sequence specifies the appropriate amino acid sequence. In addition, there are assumed to be regulatory genes which govern the rates at which the various proteins are made. The purpose of this chapter is to survey the ways in which genetic studies can contribute to our understanding of membrane structure and function. Successive sections of the chapter will discuss the criteria for establishing that differences in membrane properties are genetically determined, the kinds of information that can come from biochemical and physiological studies on membrane mutants, and the information that can be gained by genetic analysis. First, however, it will be important to define the various mutational events that can occur, and the effects of each on the structure or rate of synthesis of the corresponding protein.

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Authors and Affiliations

  1. Departments of Human Genetics and Physiology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Edward A. Adelberg & Carolyn W. Slayman

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  1. Edward A. Adelberg
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  2. Carolyn W. Slayman
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, University of Texas Medical School at Houston, 77025, Houston, TX, USA

    Thomas E. Andreoli M.D. (Professor and Chairman) (Professor and Chairman)

  2. Department of Physiology, Yale University School of Medicine, 06510, New Haven, CT, USA

    Joseph F. Hoffman Ph.D. (Eugene Higgins Professor and Chairman) (Eugene Higgins Professor and Chairman)

  3. Division of Nephrology, University of California, San Diego, 92037, La Jolla, CA, USA

    Darrell D. Fanestil M.D. (Professor of Medicine, and Head) (Professor of Medicine, and Head)

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© 1980 Springer Science+Business Media New York

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Adelberg, E.A., Slayman, C.W. (1980). Genes and Membranes. In: Andreoli, T.E., Hoffman, J.F., Fanestil, D.D. (eds) Membrane Physiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1718-1_19

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  • DOI: https://doi.org/10.1007/978-1-4757-1718-1_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1720-4

  • Online ISBN: 978-1-4757-1718-1

  • eBook Packages: Springer Book Archive

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