Skip to main content

Anatomic Pathology of Glomerulonephritis

  • Chapter
  • 156 Accesses

Abstract

Glomerulonephritis (GN) is a complex subject to study and understand. The complexity has emerged from a combination of numerous perplexing features of this pathological entity: (1) lack of unanimity in the classifications of glomerulonephritis, (2) our persistent inability in most cases to identify the direct cause or causes of glomerulonephritis, (3) limitations of light microscopy (LM) resolution in delineating finer changes, (4) wide variability in the interpretations of light microscopy findings by different individuals, and (5) the narrow scope of electron and immunofluorescence microscopy techniques around the world.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   109.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Allen, A. C.: The clinicopathologic meaning of the nephrotic syndrome. Am. J. Med. 18: 277, 1955

    Article  PubMed  CAS  Google Scholar 

  • Allen, A. C.: Glomerulonephritis. In The Kidney. An International Academy of Pathology Monograph. ( F. K. Mostofi, ed) Williams & Wilkins, Baltimore, 1966, p. 114.

    Google Scholar 

  • Allen, A. C.: Acute lobular (membranoproliferative) glomerulonephritis with hyperuricemia and obstructive uric acid nephropathy. Am. J. Clin. Pathol. 65: 109, 1976.

    PubMed  CAS  Google Scholar 

  • Avasthi, P. S.: Benign monoclonal gammaglobulinemia and glomerulonephritis. Am. J. Med. 62: 324, 1977.

    Article  Google Scholar 

  • Baldwin, D. S.: Poststreptococcal glomerulonephritis. Am. J. Med. 62: 1, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Burkholder, P. M.: Classification of renal glomerular diseases. In Atlas of Human Glomerular Pathology. Harper & Row, New York, 1974, p. 32.

    Google Scholar 

  • Cameron, J.S.: A clinician’s view of the classification of glomerulonephritis. In Glomerulonephritis: Perspectives in Nephrology and Hypertension ( P. Kincaid-Smith, T. H. Mathew, and E. L. Becker, eds.). Wiley, New York, 1972, p. 63.

    Google Scholar 

  • Churg, J., and Grishman, E.: Ultrastructure of glomerular disease: A review. Kidney Int. 7: 254, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Churg, J., Habib, R., and White, R. H.: Pathology of the nephrotic syndrome in children. Lancet 1: 1299, 1970.

    Article  Google Scholar 

  • Cordonnier, D., Martin, H., Groslambert, P., Micouin, C., Chenais, F., and Stoeber, P.: Mixed IgGIgM cryoglobulinemia with glomerulonephritis. Am. J. Med. 59: 867, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Davis, B. K., and Cavallo, T.: Membranoproliferative glomerulonephritis. Am. J. Pathol. 84: 283, 1976.

    PubMed  CAS  Google Scholar 

  • Gairdner, D.: The Schonlein-Henoch syndrome (anaphylactoid purpura). Q. J. Med. 17: 95, 1948.

    PubMed  CAS  Google Scholar 

  • Gianantonio, C. A., Vitacco, M., Mendilaharzu, F., and Gallo, G.: The hemolytic-uremic syndrome: Renal studies of 76 patients at long-term follow-up. J. Pediatr. 72: 757, 1968.

    Article  PubMed  CAS  Google Scholar 

  • Glasser, R. J., Velosh, J. A., and Michael, A. F.: Experimental model of focal sclerosis. Lab. Invest. 36: 519, 1977.

    PubMed  CAS  Google Scholar 

  • Gluck, M. C., Gallo, G., Lowenstein, J., and Baldwin, D. S.: Membranous glomerulonephritis: Evolution of clinical and pathologic features. Ann. Intern. Med. 78: 1, 1973.

    PubMed  CAS  Google Scholar 

  • Gotoff, S. P.: The laboratory and the diagnosis of glomerulonephritis. Med. Times 97: 125, 1969.

    PubMed  CAS  Google Scholar 

  • Grishman, E., and Churg, J.: Focal glomerular sclerosis in nephrotic patients: An electron microscopic study of glomerular podocytes. Kidney Int. 7: 111, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Grishman, E., Potash, J. G., Lee, S. L., and Churg, J.: Renal biopsies in lupus nephritis. Nephron 10: 25, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Gutman, R. A., Striker, G. E., Gilliland, B. C., and Cutler, R. E.: The immune complex glomerulonephritis of bacterial endocarditis. Medicine 51: 1, 1972.

    Article  PubMed  CAS  Google Scholar 

  • Habib, R.: Focal glomerular sclerosis. An editorial. Kidney Int. 4: 355, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Herdman, R. C., Pickering, R. J., Michael, A. F., Vernier, R. L., Fish, A. J., Gerwiz, H., and Good, R. A.: Chronic glomerulonephritis associated with low serum complement activity (chronic hypocomplementemic glomerulonephritis). Medicine 49 (3): 207–226, 1970.

    Article  PubMed  Google Scholar 

  • Herdson, P. B., Jennings, R. B., and Earle, D. P.: Glomerular fine structure in poststreptococcal acute glomerulonephritis. Arch. Pathol. 81: 117, 1966.

    PubMed  CAS  Google Scholar 

  • Hinglais, N., Garcia-Tones, R., and Kleinknecht, D.: Long-term prognosis in acute glomerulonephritis. Am. J. Med. 56: 52, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Hyman, L. R., and Burkholder, P. M.: Focal sclerosing glomerulopathy with segmental hyalinosis, a clinicopathological analysis. Lab. Invest. 28: 533, 1973.

    PubMed  CAS  Google Scholar 

  • Jones, D. B.: Membranoproliferative glomerulonephritis, one or many diseases? Arch. Pathol. 101: 457, 1977.

    CAS  Google Scholar 

  • Kimmelstiel, P., Kim, O. J., and Beres, J.: Studies on renal biopsy specimens with the aid of the electron microscope. II. Glomerulonephritis and glomerulonephrosis. Am. J. Clin. Pathol. 38: 280, 1962.

    PubMed  CAS  Google Scholar 

  • Lange, K., and Treser, G.: Acute poststreptococcal glomerulonephritis. Clin. Nephrol. 1: 55, 1973.

    Google Scholar 

  • Mandai, A. K., Mask, D. R., Nordquist, J., Chrysant, K., and Lindeman, R. D.: Membranous glomerulonephritis: Virus-like inclusions in glomerular basement membrane. Ann. Intern. Med. 80(4):554, 1974 (April).

    Google Scholar 

  • Mandai, A. K., Chrysant, K., and Nordquist, J. A.: Glomerulonephritis; current concepts of pathogenesis and pathology. J. Indian Med. Assoc. 65: 165, 1975.

    Google Scholar 

  • Mandai, A. K., Chrysant, K., Nordquist, J. A., Kraikitpanitch, S., Xoung, D. T., and Lindeman, R. D.: Focal glomerular sclerosis. South. Med. J. 69: 997, 1976.

    Article  Google Scholar 

  • Mandai, A. K., Kraikitpanitch, S., Nordquist, J. A., Haygood, C. C., Yunice, A. A., Oleinick, S. R., and Lindeman, R. D.: Rapid development of glomerular crescents in epinephrine infused dogs. Ann. Clin. Lab. Sci. 7: 433, 1977.

    Google Scholar 

  • McCluskey, R. T.: Human renal diseases presumed or known to result from immunologic mecha-nisms. In Cornell Seminars in Nephrology ( E. L. Becker, ed.). Wiley, New York, 1973, p. 163.

    Google Scholar 

  • McCluskey, R. T.: Lupus nephritis. In Kidney Pathology Decennial (1966–1975) ( S. C. Sommers, ed.). Appleton, New York, 1975, p. 435.

    Google Scholar 

  • McLean, R. H., Geiger, H., Burke, B., Simmons, R., Najarian, J., Vernier, R. L., and Michael, A. F.: Recurrence of membranoproliferative glomerulonephritis following kidney transplantation. Am. J. Med. 60: 60, 1976.

    Article  PubMed  CAS  Google Scholar 

  • Merrill, J. P.: Glomerulonephritis (2nd of 3 parts). N. Engl. J. Med. 290: 313, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Matalon, R., Katz, L., Gallo, G. Waldo, E., Cabaluna, C., and Eisinger, R. P.: Glomerular sclerosis in adults with nephrotic syndrome. Ann. Intern. Med. 80: 488, 1974.

    PubMed  CAS  Google Scholar 

  • Michael, A. F., Drummond, K. N., Good, R. A., and Vernier, R. L.: Acute poststreptococcal glomerulonephritis: Immune deposit disease. J. Clin. Invest. 45: 237, 1966.

    Article  PubMed  Google Scholar 

  • Morel-Maroger, L., Basch, A., Danon, F., Verroust, P., and Richet, G.: Pathology of the kidney in Waldenström’s macroglobulinemia: Study of 16 cases. N. Engl. J. Med. 283: 123, 1970.

    Article  PubMed  CAS  Google Scholar 

  • Muehrcke, R. C., Copek, A., Mandal, A. K., and Gotoff, S. P.: An auto-antibody mechanism for membranous glomerulonephritis due to renal vein thrombosis (Abstract). Ann. Intern. Med. 68: 1179, 1968.

    Google Scholar 

  • Nagi, A. H., Alexander, F., and Lannigan, R.: Light and electron microscopic studies of focal glomerular sclerosis. J. Clin. Pathol. 24: 846, 1971.

    Article  PubMed  CAS  Google Scholar 

  • Osler, W.: Erythema group of skin diseases. Am. J. Med. Sci. 127: 1, 1904.

    Article  Google Scholar 

  • Pirani, C. L., and Manaligod, J. R.: The kidneys in collagen diseases. In The Kidney. International Academy of Pathology Monograph ( F. K. Mostofi and D. E. Smith, eds.). Williams & Wilkins, Baltimore, 1966, p. 147.

    Google Scholar 

  • Pollack, V. E., and Mendoza, N.: Rapidly progressive glomerulonephritis. Med. Clin. North Am. 55: 1397, 1971.

    Google Scholar 

  • Rich, A. R.: A hitherto undescribed vulnerability of the juxtamedullary glomeruli in lipoid-nephrosis. Bull. Johns Hopkins Hosp. 100: 173, 1957.

    PubMed  CAS  Google Scholar 

  • Richet, G., Fillastre, J. P., Morel-Maroger, L., and Bariety, J.: Change from diffuse proliferative to membranous glomerulonephritis. Serial biopsies in four cases. Kidney Int. 5: 57, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Rosen, S.: Crescentic glomerulonephritis: Occurrence, mechanisms, and prognosis. In Kidney Pa-thology Decennial (1966–1975) ( S. C. Sommers, ed.). Appleton, New York, 1975, p. 361.

    Google Scholar 

  • Rosenmann, E., Dwarka, L., and Boss, J. H.: Proliferative glomerulopathy in rheumatic heart disease and chronic lung disease. Am. J. Med. Sci. 264: 213, 1972.

    PubMed  CAS  Google Scholar 

  • Turner, D. R., Whitworth, J. A., and Cameron, J. S.: The significance of segmental glomerular lesions. From the Book of Abstracts, XI International Congress of the International Academy of Pathology, Washington, D.C., 1976, p. 241.

    Google Scholar 

  • Zimmerman, S. W.: Recurrent membranoproliferative glomerulonephritis with glomerular properdin deposition in allografts. Ann. Intern. Med. 80: 169–175, 1974.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Springer Science+Business Media New York

About this chapter

Cite this chapter

Mandal, A.K. (1979). Anatomic Pathology of Glomerulonephritis. In: Electron Microscopy of the Kidney. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1699-3_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-1699-3_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1701-3

  • Online ISBN: 978-1-4757-1699-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics