Abstract
Glomerulonephritis is defined as a clinicopathological condition which characteristically involves both kidneys or only one kidney when the other kidney is congenitally absent or has been removed due to trauma, tumor, or abscess. It is characterized by the deposition of immunoglobulins (or antibody) in the glomeruli, sometimes in the tubules, and, rarely, in the interstitium and arterioles. These immunoglobulins are observed as deposits by electron and immunofluorescence microscopy. Frequently, neutrophilic leukocytes and complement components are also identified in the lesions. Other forms of glomerulonephritis, in which immunoglobulin and complement deposition are absent, also occur.
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References
Allen, A. C.: Glomerulonephritis. In The Kidney Diseases ( F. K. Mostofi, ed.). Williams & Wilkins, Baltimore, 1966, pp. 114–146.
Cameron, J. S.: A clinician’s view of the classification of glomerulonephritis. In Glomerulonephritis: Perspectives in Nephrologv and Hypertension ( P. Kincaid-Smith, T. H. Mathew, and E. L. Becker, eds.). Wiley, New York, 1972, p. 63.
Dixon, F. J.: The pathogenesis of glomerulonephritis. An editorial. Am. J. Med. 44: 493, 1968.
Dixon, F. J., Vazquez, J. J., Weigle, W. O., and Cochrane, C. G.: Pathogenesis of serum sickness. AMA Arch. Pathol. 65:18, 1958.
Ellis, A.: Natural history of Bright’s disease: Clinical, histological and experimental observation. Lancet 1:1, 1942.
Fish, A. J., Michael, A. F., Vernier, R. L., and Good, R. A.: Acute serum sickness in the rabbit (an immune deposit disease). Am. J. Pathol. 49: 997, 1966.
Gerber, M. A., and Paronetto, F.: IgE in glomeruli of patients with nephrotic syndrome. Lancer 1: 1097, 1971.
Kniker, W. T., and Cochrane, C. G.: The localization of circulating immune complexes in experimental serum sickness: The role of vasoactive amines and hydrodynamic forces. J. Exp. Med. 127: 119, 1968.
Lerner, R. A., and Dixon, F. J.: Transfer of ovine experimental allergic glomerulonephritis with serum. J. Exp. Med. 124: 431, 1966.
Levy, M., Beaufils, H., Gubler, M. C., and Habib, R.: Idiopathic recurrent macroscopic hematuria and mesangial IgA—IgG deposits in children (Berger’s Disease). Clin. Nephrol. 1: 63, 1973.
Masugi, M.: Uber die experimentelle Glomerulonephritis durch das spezifische Antinieren-Serum.
Ein Beitrag zur Pathogenese der diffusen Glomerulonephritis. Ziegler’s Beitr. Path. Anat. 92:429, 1933–1934.
McCluskey, R. T.: Human renal diseases presumed or known to result from immunologic mechanisms. In Cornell Seminars in Nephrology ( E. L. Becker, ed.). Wiley, New York, 1973, p. 163.
McCluskey, R. T., Benacerraf, B., Potter, J. L., and Miller, F.: The pathological effects of intravenously administered soluble antigen—antibody complexes: 1. Passive serum sickness in mice. J. Exp. Med. 111: 181, 1960.
Merrill, J. P.: Glomerulonephritis, part 1 of 3-part series. N. Engl. J. Med. 290: 257, 1974.
Michael, A. F., McClean, R. H., Paul Roy, L., Gunnar Westbert, N., Hoyer, J. R., Fish, A. J., and Vernier, R. L.: Immunologic aspects of the nephrotic syndrome. Kidney Int. 3: 105–115, 1973.
Stebley, R. W.: Glomerulonephritis induced in sheep by injections of heterologous glomerular basement membrane and Freund’s complete adjuvant. J. Exp. Med. 116: 253, 1962.
Volhard, F., and Fahr, T.: Die Britische Nierenkrankheit, Berlin: Springer, 1914
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Mandal, A.K. (1979). Glomerulonephritis: Pathogenesis and Classification. In: Electron Microscopy of the Kidney. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1699-3_4
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DOI: https://doi.org/10.1007/978-1-4757-1699-3_4
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