Skip to main content

Role of Protein in the Inactivation of Viruses by Ultraviolet Radiation

  • Chapter
Aging, Carcinogenesis, and Radiation Biology

Abstract

The capsomers of viruses contain proteins, lipids, and carbohydrates. The components of the capsomer frequently participate in the initial stages of the infectious process and in some instances, furnish enzymatic activity vitally needed for viral replication. The capsomers also serve to protect the viral nucleic acid from inactivation by a variety of enzymatic and physical agencies such as actinic radiation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bishop, J.M., Quintrell, N., and Koch, G., 1967, Polio virus double-stranded RNA: Inactivation by ultraviolet light, J. Mol. BioZ. 24: 125–128.

    Article  CAS  Google Scholar 

  • Bohne, L., Coquerelle, T., and Hagen, U., 1970, Radiation sensitivity of bacteriophage DNA. II. Breaks and cross-links after irradiation in vivo, Int. J. Radiat. BioZ. 17: 205–215.

    Article  CAS  Google Scholar 

  • Bonhoffer, F., and Schachman, H.K., 1960, Studies on the organization of nucleic acids within nucleoproteins, Biochem. Biophys. Res. Commun. 2: 366–371.

    Article  Google Scholar 

  • Breck, L.O., and Gordon, M.P., 1970, Formation, characterization, and some photochemical properties of a hybrid plant virus, Virology 40: 397–402.

    Article  PubMed  CAS  Google Scholar 

  • Bullock, H.R., Hollingsworth, J.P., and Hartstack, A.W., Jr., 1970, Virulence of Heliothis nuclear polyhedrosis virus exposed to monochromatic ultraviolet irradiation, J. Invert. Path. 16: 419–422.

    Article  Google Scholar 

  • Carpenter, J.M., and Kleczkowski, A., 1969, The absence of photoreversible pyrimidine dimers in the RNA of ultraviolet-irradiated tobacco mosaic virus, Virology 39: 542–547.

    Article  PubMed  CAS  Google Scholar 

  • Caspar, D.L.D., 1963, Assembly and stability of the tobacco mosaic virus particle, Adv. Protein Chem. 18: 37–121.

    Article  PubMed  CAS  Google Scholar 

  • Charlier, M., and Hélène, C., 1975, Photosensitized splitting of pyrimidine dimers in DNA by indole derivatives and tryptophancontaining peptides, Photochem. Photobiol. 21: 31–37.

    Article  PubMed  CAS  Google Scholar 

  • Francke, B., and Ray, D.S., 1972, Ultraviolet induced cross-links in the deoxyribonucleic acid of single-stranded deoxyribonucleic acid viruses as a probe of deoxyribonucleic acid packaging, J. ViroZ. 9: 1027–1032.

    CAS  Google Scholar 

  • Goddard, J., Streeter, D., Weber, C., and Gordon, M.P., 1966, Studies on the inactivation of tobacco masaic virus by ultraviolet light, Photochem. PhotobioZ. 5: 213–222.

    Article  CAS  Google Scholar 

  • Grouse, L., Murphy, T.M., Gordon, M.P., and Smuckler, E.A., 1970, The photobiology of a spherical phenotypic hybrid of tobacco mosaic virus, Virology 41: 385–388.

    Article  PubMed  CAS  Google Scholar 

  • Hawkins, R.D., 1975, Ionizing radiation induced covalent protein to DNA cross-links in coliphage T7. Abstr. Int. Symp. “Protein and Other Adducts to DNA: Their Significance to Aging, Carcinogenesis and Radiation Biology,” Williamsburg, Virginia, May 26, 1975.

    Google Scholar 

  • Hawkins, R.D., and Ginsberg, D.M., 1971, The physical measurement of radiation damage to coliphage T7 DNA, Biophys. J. 11: 398–413.

    Article  PubMed  CAS  Google Scholar 

  • Hayashi, T., Machida, H., Abe, T., and Kiho, Y., 1969, In vivo uncoating of tobacco mosaic virus irradiated with ultraviolet light, Japan J. Microbiol. 13: 386–387.

    CAS  Google Scholar 

  • Hélène, C., and Charlier, M., 1971, Photosensitized splitting of pyrimidine dimers by indole derivatives, Biochem. Biophys. Res. Commun. 43: 252–257.

    Article  PubMed  Google Scholar 

  • Huang, C.W., and Gordon, M.P., 1974, The formation of photorevers- ible cyclobutane-type pyrimidine dimers in ultravioletirradiated potato virus X, Photochem. PhotobioZ. 19: 269–272.

    Article  CAS  Google Scholar 

  • Janion, C., and Shugar, D., 1967, Reaction of amines with dihydrocytosine analogues and formation of amino acid and peptidyl derivatives of dihydropyrimidines, Acta Biochim. PoZon. 14: 293–302.

    CAS  Google Scholar 

  • Katagiri, S., Hinuma, Y., and Ishida, N., 1967, Biophysical properties of polio virus particles irradiated with ultraviolet light, Virology 32: 337–343.

    Article  PubMed  CAS  Google Scholar 

  • Kleczkowski, A., 1971, Photobiology of plant viruses, Photophysiology 6: 179–208.

    CAS  Google Scholar 

  • Kleczkowski, A., and McLaren, A.D., 1967, Inactivation of infectivity of tobacco mosaic virus during ultraviolet-irradiation of the whole virus at two wavelengths, J. Gen. Virol. 1: 441–448.

    Article  PubMed  CAS  Google Scholar 

  • Mayo, M.A., Harrison, B.D., Murant, A.F., and Barker, H., 1973, Cross-linking of RNA induced by ultraviolet irradiation of particles of raspberry ringspot virus, J. Gen. Virol. 19:155-’ 159.

    Google Scholar 

  • McCleary, L.O., and Gordon, M.P., 1973, Ultraviolet irradiation of potato virus X, its RNA and a hybrid virus particle: Photo-reactivation, kinetic isotope effects, and quantum yield of inactivation, Photochem. Photobiol. 18: 9–15.

    Article  PubMed  CAS  Google Scholar 

  • McLaren, A.D., and Kleczkowshi, A., 1967, Some gross changes in particles of tobacco mosaic virus caused by large Y 9e doses of ultraviolet radiation, J. Gen. Virol. 1: 391–394.

    Article  PubMed  CAS  Google Scholar 

  • McLaren, A.D., and Moring-Claesson, I., 1961, Action spectrum for the inactivation of infectious nucleic acid from tobacco mosaic virus by ultraviolet light, in “Progress in Photobiology” (B. Christenson and B. Buchmann, eds.), pp. 573–575, Elsevier, Amsterdam.

    Google Scholar 

  • McLean, G.D., and Crowley, N.C., 1969, Inactivation of lettuce necrotic yellow virus by ultraviolet irradiation, Virology 37: 209–213.

    Article  PubMed  CAS  Google Scholar 

  • Miller, R.L., and Plagemann, P.G.W., 1974, Effect of ultraviolet light on mengovirus: Formation of uracil dimers, instability i of capsid, and covalent linkage of and degradation op protein to gp viral RNA, J. Virol. 13: 729–739.

    PubMed  CAS  Google Scholar 

  • Nakashima, Y., and Konigsberg, W., 1975, Photo-induced cross-linkage of gene 5 protein and Fd. Abstr. Int. Symp. “Protein and Other Adducts to DNA: Their Significance to Aging, Carcinogenesis and Radiation Biology,” Williamsburg, Virginia, May 2–6, 1975.

    Google Scholar 

  • Norman, A., 1960, Ultraviolet inactivation of polio virus ribonucleic acid, Virology 10: 384–386.

    Article  PubMed  CAS  Google Scholar 

  • Oster, G., and McLaren, A.D., 1950, The ultraviolet light and photosensitized inactivation of tobacco mosaic virus, J. Gen. PhysioZ. 33: 215–228.

    Article  CAS  Google Scholar 

  • Ramoska, W.A., Stairs, G.R., and Hink, W.F., 1975, Ultraviolet light activation of insect nuclear polyhedrosis virus, Nature 253: 628–629.

    Article  PubMed  CAS  Google Scholar 

  • Remsen, J.F., Miller, N., and Cerutti, P.A., 1970, Photohydration of uridine in the RNA of coliphage R17. II. The relationship between ultraviolet inactivation and uridine photohydration, Proc. Nat. Acad. Sci. USA 65: 460–466.

    Article  PubMed  CAS  Google Scholar 

  • Rushizky, G.W., Knight, C.A., and McLaren, A.D., 1960, A comparison of the ultraviolet light inactivation of infectious ribonucleic acid preparations from tobacco mosaic virus with those of the native and reconstituted virus, virology 12: 32–47.

    Article  PubMed  CAS  Google Scholar 

  • Simukova, N.A., and Budowsky, E.I., 1974, Conversion of non-covalent interactions in nucleoproteins into covalent bonds: UV-induced formation of polynucleotide-protein crosslinks in bacteriophage Sd virions, FEBS Lett. 38: 299–303.

    Article  PubMed  CAS  Google Scholar 

  • Simukova, N.A., Turchinsky, M.F., Boni, I.V., Skoblou, Y.M., and Budowsky, E.I., 1975, UV-induced cytosine involved polynucleotide-protein cross-linking. Abstr. Int. Symp. “Protein and Other Adducts to DNA: Their Significance to Aging, Carcinogenesis and Radiation Biology,” Williamsburg, Virginia, May 2–6, 1975.

    Google Scholar 

  • Small, G.D., and Gordon, M.P., 1968, Reaction of hydroxylamine and methoxyamine with the ultraviolet-induced hydrate of cytidine, J. Mol. Biol. 34: 281–291.

    Article  PubMed  CAS  Google Scholar 

  • Streeter, D.G., and Gordon, M.P., 1967, Ultraviolet photoinactivation studies on hybrid viruses obtained by the cross-reconstitution of the protein and RNA components of U(1) and U(2) strains of TMV, Photochem. PhotobioZ. 6: 413–421.

    Article  CAS  Google Scholar 

  • Streeter, D.G., and Gordon, M.P., 1968, Studies of the role of the coat protein in the ultraviolet photoinactivation of U(1) and U(2) strains of TMV, Photochem. Photobiol. 8: 81–92.

    Article  CAS  Google Scholar 

  • Tao, M., Small, G.D., and Gordon, M.P., 1969, Photochemical alterations in ribonucleic acid isolated from ultraviolet-irradiated tobacco mosaic virus, virology 39: 534–541.

    Article  PubMed  CAS  Google Scholar 

  • Turchinsky, M.F., Boni, I.V., and Budowsky, E.I., 1975, Bisulfite induced cytosine involved polynucleotide-protein cross-linking. Abstr. Int. Symp. “Protein and Other Adducts to DNA: Their Significance to Aging, Carcinogenesis and Radiation Biology,” Williamsburg, Virginia, May 2–6, 1975.

    Google Scholar 

  • Turchinsky, M.F., Jusova, K.S., and Budowsky, E.I., 1974, Conversion of non-covalent interaction sin nucleoproteins in to covalent bonds: Bisulfide induced formation of polynucleotide-protein crosslinks in MS2 bacteriophage virions, FEBS Lett. 38: 304–307.

    Article  PubMed  CAS  Google Scholar 

  • Yamada, Y. Shigeta, A., and Nogu, K., 1973, Ultraviolet effects on biological functions of RNA phage MS2, Biochim. Biophys. Acta 299: 121–135.

    Article  CAS  Google Scholar 

  • Zech, H., 1961, Cytochemische untersuchungen zur reproduktion des tabakmosaikvirus, Z. Naturforsch. 16b: 520–538.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Springer Science+Business Media New York

About this chapter

Cite this chapter

Gordon, M.P. (1976). Role of Protein in the Inactivation of Viruses by Ultraviolet Radiation. In: Smith, K.C. (eds) Aging, Carcinogenesis, and Radiation Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1662-7_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-1662-7_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1664-1

  • Online ISBN: 978-1-4757-1662-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics