Skip to main content
SpringerLink
Log in

Genetic Manipulation of Neuroanatomical Traits

  • Chapter
Knowing, Thinking, and Believing

Abstract

It was probably in 1954 at the Berkeley Faculty Club, around the large table in the middle of the dining room, where there gathered regularly for lunch an exciting conglomeration of individuals representing a variety of academic disciplines, mutually attracted to each other for who knows what reasons, that David Krech held forth on his new research forays into the field of brain chemistry and behavior. Imagine his enthusiasm! … the vast horizons opening up with elucidation of the biochemical basis of behavioral patterns; imagine the responses! … some looking up, others with eyes steadfast on their soup bowls. Probably Everett Dempster from the Department of Genetics at least raised his eyebrows, for his interests were vast and specifically encompassed the question of the extent of genetic variation in the causes of behavioral variation. Krech, persisting, undoubtedly continued telling of Melvin Calvin's interest in the problem and the already significant scientific role Edward Bennett was taking in the biochemistry of the visual and somesthetic areas of the rat brain

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ackerman, DF1965Escape learning in mice selected for brain weightUnpublished student paper, Jackson Laboratory, Bar Harbor, Me.

    Google Scholar 

  • Bailey, DW1971Recombinant-inbred strains: An aid to finding identity, linkage, and function of histocompatibility and other genesTransplantation, 11, 325-327.

    Article  PubMed  Google Scholar 

  • Barber, RP., Vaughn, JE., Wimer, RE., and Wimer, CC1974Genetically-associated variations in the distribution of dentate granule cell synapses upon the pyramidal cell dendrites in mouse hippocampusJournal of Comparative Neurology, 156, 417-434.

    Article  PubMed  Google Scholar 

  • Bentley, D., and Hoy, RR1974The neurobiology of cricket songScientific American, 231, 34-44.

    Article  PubMed  Google Scholar 

  • Bolles, RG1970Species-specific defense reactions and avoidance learningPsychological Review, 77, 32-48.

    Article  Google Scholar 

  • Buckley, PA1969Disruption of species-typical behaviour patterns in Fhybrid Agapornis parrotsZeitschrift fuer Tierpsychologie, 26, 737-743.

    Article  Google Scholar 

  • Caviness, VS., Jr., So, DK., and Sidman, RL1972The hybrid reeler mouseJournal of Heredity, 63, 241-246.

    PubMed  Google Scholar 

  • Collins, R.-A1970Experimental modification of brain weight and behavior in mice: An enrichment studyDevelopmental Psychobiofoy, 3, 145-155.

    Article  Google Scholar 

  • Cooper, RM., and Zubek, JP1958Effects of enriched and restricted early environments on the learning ability of bright and dull ratsCanadian Journal of Psychology, 12, 159-164.

    Article  PubMed  Google Scholar 

  • Diamond, IT., and Hall, CW1969Evolution of neocortex Science, 164, 251-262.

    Article  PubMed  Google Scholar 

  • Dilger, WC1962The behavior of lovebirdsScientific American, 206, 88-98.

    Article  Google Scholar 

  • Dobzhansky, Th1972Genetics and the diversity of behaviorAmerican Psychologist, 27, 523-530.

    Article  PubMed  Google Scholar 

  • Dravid, AR., Wimer, RE., and Herschman, HR1972Biochemical bases for genetically determined brain weight phenotypesTransactions of the American Society of Neurochemistry, 3, 1972 (abstract).

    Google Scholar 

  • Eleftheriou, BE., Bailey, DW., and Denenberg, VH1974Genetic analysis of fighting behavior in micePhysiology and Behavior, 13, 773-777.

    Google Scholar 

  • Elias, MF 1969 Differences in spatial discrimination reversal learning for mice genetically selected for high brain weight and unselected controlsPerceptual and Motor Skills, 28, 707-712.

    Article  PubMed  Google Scholar 

  • Erlenmeyer-Kimling, L 1972 Gene-environment interaction and the variability of behaviorIn: Genetics, Environment and BehaviorLEhrman, GSOmenn, and ECaspari (Eds.)Academic Press, New York, pp181-208.

    Google Scholar 

  • Falconer, DS1960Quantitative GeneticsRonald Press, New York.

    Google Scholar 

  • Falconer, DS1973Replicated selection for body weight in miceGenetical Research, 22, 291-321.

    Article  PubMed  Google Scholar 

  • Fuller, JL1957The genetic base: Pathways between genes and behavioral characteristicsIn: The Nature and Transmission of the Genetic and Cultural Characteristics

    Google Scholar 

  • of Human Populations, Proceedings of the 1956 Annual Conference, Milbank Memorial Fund, 40 Wall St., New York.

    Google Scholar 

  • Fuller, JL., and Geils, HD1972Brain growth in mice selected for high and low brain weightDevelopmental Psychobiology, 5 307-318.

    Article  PubMed  Google Scholar 

  • Fuller, JLand Geils, HD1973Behavioral development in mice selected for differences in brain weightDevelopmental Psychobiology, 6, 469-474.

    Article  PubMed  Google Scholar 

  • Fuller, JL., and Wimer, RE1973Behavior geneticsIn: Comparative Psychology: A Modern SurveyDADewsbury and DARethlingshafer (Eds.)McGraw-Hill, New York, pp197-237.

    Google Scholar 

  • Fuller, JL., Brady-Wood, S., and Elias, MF1973Effects of retinal degeneration and brain size upon spatial reversal learning in micePerceptual and Motor Skills, 36, 947-950.

    Article  PubMed  Google Scholar 

  • Gonsiorek, JC., Donovick, PJ., Burright, RG., and Fuller, JL1974Aggression in low and high brainweight mice following septal lesionsPhysiology and Behavior, 12, 813-818.

    Article  PubMed  Google Scholar 

  • Gould, J1966Effects of changes in total brain size on specific brain structures in miceUnpublished student paper, Jackson Laboratory, Bar Harbor, Me.

    Google Scholar 

  • Green, EL1974Some systems of mating useful in mouse geneticsExperimentation Animate, 7, l-14.

    Google Scholar 

  • Green, MC1966Mutant genes and linkagesIn: Biology of the Laboratory Mouse (2nd ed.)ELGreen (Ed.)McGraw-Hill, New York, pp87-150.

    Google Scholar 

  • Hagerich, JA1968Investigation of the causes of brain weight variation in miceUnpublished student paper, Jackson Laboratory, Bar Harbor, Me.

    Google Scholar 

  • Hamilton, JA1935The association between brain size and maze ability in white ratsUnpublished Ph.Ddissertation, University of California, Berkeley.

    Google Scholar 

  • Hinde, RA., and Stevenson-Hinde, J(Eds.) 1973Constraints on Learning: Limitations and PredispositionsAcademic Press, New York.

    Google Scholar 

  • Hirsch, J(Ed.) 1967Behavior-Genetic AnalysisMcGraw-Hill, New York.

    Google Scholar 

  • Hodos, W., and Campbell, CBG1969Scala naturae: Why there is no theory in comparative psychologyPsychological Review, 76, 337-350.

    Google Scholar 

  • Krompecher, St., and Lipak, J1966A simple method for determining cerebralization: Brain weight and intelligenceJournal of Comparative Neurology, 127, 113-120.

    Google Scholar 

  • Lashley, K.S 1949 Persistent problems in the evolution of mindQuarterly Review of Biology, 24, 28-42.

    Google Scholar 

  • Mayr, E1974Behavior programs and evolutionary strategiesAmerican Scientist, 62, 650-659.

    PubMed  Google Scholar 

  • Miller, GA., Galanter, E., and Pribram, KH1960Plans and the Structure of Behavior Holt, Rinehart and Winston, New York.

    Google Scholar 

  • Powers, WT1973Behavior: The Control of PerceptionAldine, Chicago.

    Google Scholar 

  • Rakic, P., and Sidman, RL1973Weaver mutant mouse cerebellum: Defective neuronal migration secondary to abnormality of Bergmann gliaProceedings of the National Academy of Sciences of the United States of America, 70, 240-244.

    Article  Google Scholar 

  • Rensch, B1956Increase of learning capability with increase of brain-sizeAmerican Naturalist, 90, 81-95.

    Article  Google Scholar 

  • Rensch, B1964Memory and concepts of higher animalsProceedings of the Zoological Society (Calcutta), 17, 207-221.

    Google Scholar 

  • Roderick, TH1960Selection for cholinesterase activity in the cerebral cortex of the ratGenetics, 45, 1123-1140.

    PubMed  Google Scholar 

  • Roderick, TH., and Hawes, NL1974Nineteen paracentric chromosomal inversions in miceGenetics, 76, 109-117.

    PubMed  Google Scholar 

  • Roderick, TH., Wimer, RE., Wimer, CC., and Schwartzkroin, PA1973Genetic and phenotypic variation in weight of brain and spinal cord between inbred strains of miceBrain Research, 64, 345-353.

    Article  PubMed  Google Scholar 

  • Rothenbuhler, WC1964Behavior genetics of nest cleaning in honey beesIVResponses of F1 and backcross generations to disease-killed broodAmerican Zoologist, 4, 111-123.

    Google Scholar 

  • Russell, WMS1958Evolutionary concepts in behavioral scienceICybernetics, Darwinian theory and behavioral scienceGeneral Systems, 3, 18-28.

    Google Scholar 

  • Seligman, MEP1970On the generality of the laws of learningPsyclwlogical Review, 77, 406-418.

    Article  Google Scholar 

  • Sheldon, MH1968LearningIn: Analysis of Behavioral ChangeLWeiskrantz (Ed.)Harper and Row, New York, pp127-157.

    Google Scholar 

  • Sidman, RL1968Development of interneuronal connections in brains of mutant miceIn: Physiological and Biochemical Aspects of Nervous IntegrationFDCarlson (Ed.)Prentice-Hall, New York, pp163-194.

    Google Scholar 

  • Sidman, RL., and Green, MC1965Retinal degeneration in the mouse; location of the rd locus in linkage group XVIIJournal of Heredity, 56, 23-29.

    PubMed  Google Scholar 

  • Sidman, RL., Green, MC., and Appel, SH1965Catalog of the Neurological Mutants of the MouseHarvard University Press, Cambridge, Mass.

    Google Scholar 

  • Staats, J1966The laboratory mouseIn: Biology of the Laboratory Mouse (2nd ed.)ELGreen (Ed.)McGraw-Hill, New York, pp1-9.

    Google Scholar 

  • Storer, JB1967Relation of lifespan to brain weight, body weight and metabolic rate among inbred mouse strainsExperimental Gerontology, 2, 173-182.

    Article  Google Scholar 

  • Terris, AD1964Behavior differences in mice selected for brain sizeUnpublished student report, Jackson Laboratory, Bar Harbor, Me.

    Google Scholar 

  • Waller, MP., Waller, PF., and Brewster, LA1960A water maze for use in studies of drive and learningPsychological Reports, 7, 99-102.

    Google Scholar 

  • Wimer, C., and Prater, L1966Some behavioral differences in mice genetically selected for high and low brain weightPsychological Reports, 19, 675-681.

    Article  PubMed  Google Scholar 

  • Wimer, C., Roderick, TH., and Wimer, RE1969Supplementary report: Behavioral differences in mice genetically selected for brain weightPsychological Reports, 25, 363-368.

    Article  PubMed  Google Scholar 

  • Wimer, C., Wimer, RE., and Roderick, TH1971Some behavioral differences associated with relative size of hippocampus in the mouseJournal of Comparative and Physiological Psychology, 76, 57-65.

    Article  Google Scholar 

  • Wimer, RE1973Dissociation of a phenotypic correlation: Response to posttrial etherization and to temporal distribution of practice trialsBehavior Genetics, 3, 379-386.

    Article  PubMed  Google Scholar 

  • Wimer, RE., and Weller, S1965Evaluation of a visual discrimination task for the analysis of the genetics of a mouse behaviorPerceptual and Motor Skills, 20, 203-208.

    Article  PubMed  Google Scholar 

  • Wimer, RE., Symington, L., Farmer, H., and Schwartzkroin, P1968Differences in memory processes between inbred mouse strains C57BL/6J and DBA/21Journal of Comparative and Physiological Psychology, 65, 126-131.

    Article  Google Scholar 

  • Wimer, RE., Wimer, CC., and Roderick, TH1969Genetic variability in forebrain structures between inbred strains of miceBrain Research, 16, 257-264.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Jackson Laboratory, Bar Harbor, Maine, USA

    Thomas H. Roderick

  2. Division of Neurosciences, City of Hope National Medical Center, Duarte, California, USA

    Richard E. Wimer & Cynthia C. Wimer

Authors
  1. Thomas H. Roderick
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Richard E. Wimer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Cynthia C. Wimer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Psychology, University of California, Riverside, California, USA

    Lewis Petrinovich

  2. Department of Psychobiology, School of Biological Sciences, University of California, Irvine, California, USA

    James L. McGaugh

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Springer Science+Business Media New York

About this chapter

Cite this chapter

Roderick, T.H., Wimer, R.E., Wimer, C.C. (1976). Genetic Manipulation of Neuroanatomical Traits. In: Petrinovich, L., McGaugh, J.L. (eds) Knowing, Thinking, and Believing. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1653-5_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-1653-5_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1655-9

  • Online ISBN: 978-1-4757-1653-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation