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Bone Regulatory Factors pp 161–166Cite as

Osteogenin: Role in Bone Induction and Repair

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Part of the book series: NATO ASI Series ((NSSA,volume 184))

Abstract

Bone has considerable potential for repair and regeneration. The aim of this article is to provide a concise review of bone induction. It presents the hypothesis that endogenous growth and differentiation factors isolated from bone matrix in conjunction with exogenous growth factors isolated from elsewhere will initiate and promote cartilage and bone repair. The potential for regeneration and repair of skeletal tissue is well known from the days of Hippocrates in ancient Greece. Almost a century ago Senn (1) described the utility of decalcified bone implants in the care of osteomyelitis. Pierre Lacroix (2), a Belgian orthopaedic surgeon proposed that bone may contain a substance christened “osteogenin” which may initiate bone growth. Marshall Urist (3) made the key discovery that demineralized, lyophilized bone matrix induced bone formation. Bone induction by demineralized bone matrix recapitulates the stages of long bone development (4–7).

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Authors and Affiliations

  1. Bone Cell Biology Section National Institute of Dental Research, National Institutes of Health, Bethesda, MD, 20892, USA

    A. H. Reddi & S. Ma

Authors
  1. A. H. Reddi
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  2. S. Ma
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Editor information

Editors and Affiliations

  1. University of Milan, Milan, Italy

    Antonio Pecile (Professor of Pharmacology) (Professor of Pharmacology)

  2. Biophysics and Chemistry of Macromolecules, University of Trieste, Trieste, Italy

    Benedetto de Bernard (Head of the Dept. of Biochemistry) (Head of the Dept. of Biochemistry)

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© 1990 Springer Science+Business Media New York

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Reddi, A.H., Ma, S. (1990). Osteogenin: Role in Bone Induction and Repair. In: Pecile, A., de Bernard, B. (eds) Bone Regulatory Factors. NATO ASI Series, vol 184. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1508-8_10

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  • DOI: https://doi.org/10.1007/978-1-4757-1508-8_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1510-1

  • Online ISBN: 978-1-4757-1508-8

  • eBook Packages: Springer Book Archive

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