Abstract
Association of pineal function with flow or content of the cerebrospinal fluid (CSF) is a very old concept. In western civilization it came into prominent view with the writings of Herophilos of Alexandria (325–280 BC). However, then and through many subsequent centuries, this functional association was based essentially on philosophical speculations, which were contested and eventually discredited, bringing down with them many of the notions derived from, and dependent upon, them. This long and faltering early phase of “pinealology” corresponds to the first of the three periods in pineal research as summarized by Kappers (1979).
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References
Agnew, W. F., Yuen, T. G. H., and Achtyl, T. R., 1980, Ultrastructural observations suggesting apocrine secretion in the choroid plexus: A comparative study, Neurological Research, 1: 313.
Allen, D. J., Highison, G. J., Werneck, H., and Gentry, G., 1981, Morphological specializations of the ventricular surface of the choroidal epithelium and associated epiplexus cells, in: Eleventh International Congress of Anatomy: Advances in the Morphology of Cells and Tissues, p. 11, Alan R. Liss, New York.
Arendt, J., Wetterberg, L., Heyden, T., Sizonenko, and Paunier, L., 1977, Radioimmunoassay of melatonin: Human serum and cerebrospinal fluid, Hormone Res., 8: 65.
Brown, G. M., Young, S. N., Gauthier, S., Tsui, H., and Grota, L. J., 1979, Melatonin an human cerebrospinal fluid in daytime: Its origin and variation with age, Life Sci., 25: 929.
Davis, D. A., and Milhorat, T. H., 1975, The blood-brain barrier of the rat choroid plexus, Anat. Rec., 181: 779.
Decker, J. F., and Quay, W. B., in press, Stimulatory effects of melatonin on ependymal epithelium of choroid plexuses in Golden Hamsters, J. Neural Transmission.
Rusted, R. F., and Reed, D. J., 1976, Regulation of cerebrospinal fluid potassium by the cat choroid plexus, J. Physiol., 259: 213.
Kappers, J. A., 1979, Short history of pineal discovery and research, Prog. Brain Res., 52: 3.
Koshiba, K., Oshima, H., and Uematsu, H., 1980, Fine structure of the choroid plexus in pigeon by transmission electron microscopy, J. Electron Microscopy, 29: 129.
Langford, L. A., and Coggeshall, R. E., 1980, The use of potassium ferricyanide in neural fixation, Anat. Rec., 197: 297.
Lindvall, M., Edvinsson, L., and Owman, Ch., 1977, Histochemical, ultrastructural and functional evidence for a neurogenic control of cerebrospinal fluid production from the choroid plexus, Acta Physiol. Scand., Suppl. 452: 77.
Masuzawa, T., Saito, T., and Sato, F., 1981, Cytochemical study on enzyme activity associated with cerebrospinal fluid secretion in the choroid plexus and ventricular ependyma, Brain Res., 222: 309.
Mess, B., and Trentini, G. P., 1974, 3H-Melatonin level in cerebrospinal fluid and choroid plexus following intravenous administration of the labelled compound, Acta Physiol. Acad. Sci. Hung., 45: 225.
Mollenhauer, H. H., 1964, Plastic embedding mixtures for use in electron microscopy, Stain Technol., 39: 111.
Otani, T., Gy8rkey, F., and Farrell, G., 1968, Enzymes of the human pineal body, J. Clin. Endocrinol. Metab., 28: 349.
Perlow, M. J., Reppert, S. M., Boyar, R. M., and Klein, D. C., 1981, Daily rhythms in cortisol and melatonin in primate cerebrospinal fluid. Effects of constant light and dark, Neuroendocrinology, 32: 193.
Quay, W. B., 1965, Experimental evidence for pineal participation in homeostasis of brain composition, Prog. Brain Res., 10: 646.
Quay, W. B., 1966, Regional differences in metabolism and composition of choroid plexuses, Brain Res., 2: 378.
Quay, W. B., 1969, The role of the pineal gland in environmental adaptation, in: “Physiology and Pathology of Adaptation Mechanisms,” E. Bajusz, ed., p. 508, Pergamon Press, Oxford and New York.
Quay, W. B., 1970a, Experimental studies of brain water content and its 24-hour rhythmicity, Rassegna Neurologia Vegetativa, 24: 1.
Quay, W. B., 1970b, Endocrine effects of the mammalian pineal, Am. Zool., 10: 237.
Quay, W. B., 1972, Regional and quantitative differences in the post-weaning development of choroid plexuses in the rat brain, Brain Res., 36: 37.
Quay, W. B., 1974a, “Pineal Chemistry in Cellular and Physiological Mechanisms,” Charles C Thomas, Springfield.
Quay, W. B., 1974b, Temporal mitotic patterns around a brain lesion: Cellular and regional asynchronisms and an effect of pinealectomy, Chronobiologia, 1: 237.
Quinton, P. M., Wright, E. M., and Tormey, J. M., 1973, Localization of sodium pumps in the choroid plexus epithelium. J. Cell Biol., 58: 724.
Sahar, A., 1972a, Choroidal origin of cerebrospinal fluid, Israel J. Med. Sci., 8: 594.
Sahar, A., 1972b, The effect of pressure on the production of cerebrospinal fluid by the choroid plexus, J. Neurol. Sci., 16: 49
Smith, I., Mullen, P. E., Silman, R. E., Snedden, W., and Wilson, B. W., 1976, Absolute identification of melatonin in human plasma and cerebrospinal fluid, Nature, 260: 718.
Smith, J. A., Barnes, J. L., and Mee, T. J., 1979, The effect of neuroleptic drugs on serum and cerebrospinal fluid melatonin concentrations in psychiatric subjects, J. Pharm. Pharmacol., 31: 246.
Smulders, A. P., and Wright, E. M., 1980, Role of choroid plexus in transport of melatonin between blood and brain, Brain Res., 191: 555.
Tan, C. H., and Khoo, J. C. M., 1981, Melatonin concentrations in human serum, ventricular and lumbar cerebrospinal fluids as an index of the secretory pathway of the pineal gland, Hormone Res., 14: 224.
Trentini, G. P., Mess, B., De Gaetani, C. F., and Ruzsas, C., 1979, Pineal-brain relationship, Prog. Brain Res., 52: 341.
Vaughan, G. M., McDonald, S. D., Jordan, R. M., Allen, J. P., Bohmfalk, G. L., Abou-Samra, M., and Story, J. L., 1978, Melatonin concentration in human blood and cerebrospinal fluid: Relationship to stress, J. Clin. Endocrinol. Metab., 47: 220.
Venable, J. H., and Coggeshall, R., 1965, A simplified lead citrate stain for use in electron microscopy, J. Cell Biol., 25: 407.
Walter, F. K., 1923, Weitere Untersuchungen zur Pathologie und Physiologie der Zirbeldrüse, Z. Ges. Neurol. Psychiatrie, 83: 411.
Weiss, M. H., and Wertman, N., 1978, Modulation of CSF production by alterations in cerebral perfusion pressure, Arch. Neurol., 35: 527.
Westergaard, E., 1970, “The Lateral Cerebral Ventricles and Their Ventricular Walls,” Andelsbogtrykkeriet, Odense.
Withyachumnarnkul, B., and Knigge, K. M., 1980, Melatonin concentration in cerebrospinal fluid, peripheral plasma and plasma of the confluens sinuum of the rat, Neuroendocrinology, 30: 382.
Wright, E. M., 1972, Mechanisms of ion transport across the choroid plexus, J. Physiol., 226: 55.
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© 1983 Springer Science+Business Media New York
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Quay, W.B. (1983). Actions of the Pineal Gland and Melatonin on the Secretion of Cerebrospinal Fluid. In: Axelrod, J., Fraschini, F., Velo, G.P. (eds) The Pineal Gland and its Endocrine Role. NATO Advanced Science Institutes Series, vol 65. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1451-7_19
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DOI: https://doi.org/10.1007/978-1-4757-1451-7_19
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