Skip to main content

Analysis of Macrophage Differentiation and Function with Monoclonal Antibodies

  • Chapter
Macrophage Activation

Part of the book series: Contemporary Topics in Immunobiology ((CTI,volume 13))

Abstract

A large number of anti-mouse and anti-human macrophage/monocyte monoclonal antibodies (MAb) have recently been obtained that are proving invaluable reagents of extraordinary specificity for the study of macrophage differentiation, function, and surface antigen structure. This chapter summarizes information on such MAb reported up to February 1983 in tabular form, and then concentrates in more detail on antigens characterized by the authors and their collaborators.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anderson, C. L., 1982, Isolation of the receptor for IgG from a human monocyte cell line (U937) and from human peripheral blood monocytes, J. Exp. Med. 156: 1794–1805.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, C. L., and Abraham, G. N., 1980, Characterization of the Ic receptor for IgG on a human macrophage cell line, U937, J. Immunol. 125: 2735–2741.

    PubMed  CAS  Google Scholar 

  • Ault, K. A., and Springer, T. A., 1981, Cross reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells, J. Immunol. 126: 359–364.

    PubMed  CAS  Google Scholar 

  • Austyn, J. M., and Gordon, S., 1981, F4/80, a monoclonal antibody directed specifically against the mouse macrophage, Eur. J. Immunol. 11: 805–815.

    Article  PubMed  CAS  Google Scholar 

  • Ball, E. D., Graziano, R. F., Shen, L., and Fanger, M. W., 1982, Monoclonal antibodies to novel myeloid antigens reveal human neutrophil heterogeneity, Proc. Natl. Acad. Sci. USA 79: 5374–5378.

    Article  PubMed  CAS  Google Scholar 

  • Basch, R. S., and Berman, J. W., 1982, Thy-1 determinants are present on many murine hematopoietic cells other than T cells, Eur. J. Immunol. 12: 359–364.

    Article  PubMed  CAS  Google Scholar 

  • Becker, G. J., Hancock, W. W., Kraft, N., Lanyon, H. C., and Atkins, R. C., 1981, Monoclonal antibodies to human macrophage and leucocyte common antigens, Pathology 13: 669–680.

    Article  PubMed  CAS  Google Scholar 

  • Beller, D. I., Kiely, J. M., and Unanue, E. R., 1980, Regulation of macrophage populations. I. Preferential induction of la-rich peritoneal exudates by immunologic stimuli, J. Immunol. 124: 1426–1432.

    PubMed  CAS  Google Scholar 

  • Beller, D. I., Springer, T. A., and Schreiber, R. D., 1982, Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor, J. Exp. Med. 156: 1000–1009.

    Article  PubMed  CAS  Google Scholar 

  • Berken, A., and Benacerraf, B., 1966, Properties of antibodies cytophilic for macrophages, J. Exp. Med. 123: 119–144.

    Article  PubMed  CAS  Google Scholar 

  • Berman, B., and Gigli, I., 1980, Complement receptors on guinea pig epidermal Langerhans cells, J. Immunol. 124: 685–690.

    PubMed  CAS  Google Scholar 

  • Bernstein, I. D., Andrews, R. G., Cohen, S. F., and McMaster, B. E., 1982, Normal and malignant human myelocytic and monocytic cells identified by monoclonal antibodies, J. Immunol. 128: 876–881.

    PubMed  CAS  Google Scholar 

  • Bianco, C., and Nussenzweig, V., 1977, Complement receptors, Contemp. Top. Mol. Immunol. 6: 145–176.

    Article  PubMed  CAS  Google Scholar 

  • Boltz-Nitulescu, G., Bazin, H., and Spiegelberg, H. L., 1981, Specificity of Fc receptors for IgG2a, IgGI/IgG2b, and IgE on rat macrophages, J. Exp. Med. 154: 374–384.

    Article  PubMed  CAS  Google Scholar 

  • Breard, J., Reinherz, E. L., Kung, P. C., Goldstein, G.,’ and Schlossman, S. F., 1980, A monoclonal antibody reactive with human peripheral blood monocytes, J. Immunol. 124: 1943–1948.

    CAS  Google Scholar 

  • Breard, J., Reinherz, E., O’Brien, C., and Schlossman, S. F., 1981, Delineation of an effector population responsible for natural killing and antibody-dependent cellular cytotoxicity in man, Clin. Immunol Immunopathol. 18: 145–150.

    Article  PubMed  CAS  Google Scholar 

  • Brooks, C. G., Kuribayashi, K., Sale, G. E., and Henney, C. S., 1982, Characterization of five cloned murine cell lines showing high cytolytic activity against YAC-1 cells, J. Immunol. 128: 2326–2335.

    PubMed  CAS  Google Scholar 

  • Burckhardt, J. J., Anderson, W. H. K., Kearney, J. F., and Cooper, M. D., 1982, Human blood monocytes and platelets share a cell surface component, Blood 60: 767–771.

    PubMed  CAS  Google Scholar 

  • Burke, K., and Gigli, I., 1980, Receptors for complement on Langerhans cells, J. Invest.Dermatol. 75: 46–51.

    Article  PubMed  CAS  Google Scholar 

  • Carlo, J. R., Ruddy, S., Studer, E. J., and Conrad, D. H., 1979, Complement receptor binding of C3b-coated cells treated with C3b inactivator 0–1H globulin and tyrpsin, J. Immunol. 123: 523–528.

    PubMed  CAS  Google Scholar 

  • Collins, S. J., Ruscetti, F. W., Gallagher, R. E., and Gallo, R. C., 1978, Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds, Proc. Natl. Acad. Sci. USA 75: 2458–2462.

    Article  PubMed  CAS  Google Scholar 

  • Crabtree, G. R., 1980, Fc receptors of a human promyelocytic leukemic cell line: Evidence for two types of receptors defined by binding of the staphylococcal protein A-IgGI complex, J. Immunol. 127: 448–453.

    Google Scholar 

  • Davignon, D., Martz, E., Reynolds, T., Kürzinger, K., and Springer, T. A., 1981, Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1): Mechanism of blocking of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions, J. Immunol. 126: 590–595.

    Google Scholar 

  • Diamond, B., and Scharff, M. D., 1980, IgGI and IgG2b share the Fc receptor on mouse macrophages, J. Immunol. 125: 631–633.

    PubMed  CAS  Google Scholar 

  • Diamond, B., and Yelton, D. E., 1981, A new Fc receptor on mouse macrophages binding IgG3, J. Exp. Med. 153: 514–519.

    Article  PubMed  CAS  Google Scholar 

  • Dickler, H. B., 1976, Lymphocyte receptors for imrnunoglobulin, in: Advances in Immunology, Vol. 24 ( F. J. Dixon, and H. G. Kunkel, eds.), pp. 167–214, Academic Press, New York.

    Google Scholar 

  • Dimitriu-Bona, A., Burmester, G. R., Waters, S. J., and Winchester, R. J., 1983, Human mononuclear phagocyte differentiation antigens. 1. Patterns of antigenic expression on the surface of human monocytes and macrophages defined by monoclonal antibodies, J. Immunol. 130: 145–152.

    PubMed  CAS  Google Scholar 

  • Ezekowitz, R. A. B., Austyn, J., Stahl, P. D., and Gordon, S., 1981, Surface properties of bacillus Calmette-Guérin-activated mouse macrophages. Reduced expression of mannose-specific endocytosis, Fc receptors, and antigen F4/80 accompanies induction of Ia, J. Exp. Med. 154: 60–76.

    Article  PubMed  CAS  Google Scholar 

  • Ezekowitz, R. A. B., Bampton, M., and Gordon, S., 1983, Macrophage activation selectively enhances expression of Fc receptors for IgG2a, J. Exp. Med. 157: 807–812.

    Article  PubMed  CAS  Google Scholar 

  • Fearon, D. T., and Wong, W. W., 1983, Complement ligand-receptor interactions that mediate biological responses, Annu. Rev. Immunol. 1: 243–271.

    Article  PubMed  CAS  Google Scholar 

  • Ferrero, D., Pessano, S., Pagliardi, G. L., and Rovera, G., 1983, Induction of differentiation of human myeloid leukemias: Surface changes probed with monoclonal antibodies, Blood 61: 171–179.

    PubMed  CAS  Google Scholar 

  • Fithian, E., Kung, P., Goldstein, G., Rubenfeld, M. Fenoglio, C., and Edelson, R., 1981, Reactivity of Langerhans cells with hybridoma antibody, Proc. Natl. Acad. Sci. USA 78: 2541–2544.

    Article  CAS  Google Scholar 

  • Fleit, H. B., Wright, S. D., and Unkeless, J. C., 1982, Human neutrophil Fc-gamma receptor distribution and structure, Proc. Natl. Acad. Sci. USA 79: 3275–3279.

    Article  PubMed  CAS  Google Scholar 

  • Fleit, H. B., Wright, S. D., Dune, C. J., Valinsky, J. E., and Unkeless, J. C., 1984, Ontogeny of Fc receptors and complement receptors (CR3) during human myeloid differentiation, J. Clin. Invest. (in press).

    Google Scholar 

  • Flotte, T., Springer, T. A., and Thorbecke, G. J. 1983a, Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets, Am J. Patho1. 111: 112–124.

    CAS  Google Scholar 

  • Flotte, T. J., Haines, K. A., Peckman, K., Springer, T. A., Gigli, I., and Thorbecke, J., 1984, The relation of Langerhans cells to other dendritic cells and macrophages, In Mononuclear Phagocyte Biology (A. Volkman, ed.), Academic Press, New York (in press).

    Google Scholar 

  • Frank, M. M., Lawley, T. J., Hamburger, M. I., and Brown, E. J., 1983, Immunoglobulin G Fc receptor-mediated clearance in autoimmune diseases, Ann. Intern. Med. 98: 206218.

    Google Scholar 

  • Germain, R. N., Bhattacharya, A., Dorf, M. E., and Springer, T. A., 1982, A single monoclonal anti-Ia antibody inhibits antigen-specific T cell proliferation controlled by distinct Ir genes mapping in different H-2 I subregions, J. Immunol. 128: 1409–1413.

    PubMed  CAS  Google Scholar 

  • Griffin, J. D., Ritz, J., Nadler, L. M., and Schlossman, S. F., 1981, Expression of myeloid differentiation antigens on normal and malignant myeloid cells, J. Clin. Invest. 69: 932–941.

    Article  Google Scholar 

  • Griffin, J. D., Beveridge, R. P., and Schlossman, S. F., 1982, Isolation of myeloid progenitor cells from peripheral blood of chronic myelogenous leukemia patients, Blood 60: 30–37.

    PubMed  CAS  Google Scholar 

  • Haeffner-Cavaillon, N., Klein, M., and Dorrington, K. J., 1979, Studies on the Fc gamma receptor of the murine macrophage-like cell line P388D1 1. The binding of homologous and heterologous immunoglobulin G, J. Immunol. 123: 1905–1913.

    PubMed  CAS  Google Scholar 

  • Haines, K. A., Flotte, T. J., Springer, T. A., Gigli, I., and Thorbecke, G. J., 1983, Staining of Langerhans cells with monoclonal antibodies to macrophages and lymphoid cells, Proc. Natl. Acad. Sci. USA 80: 3448–3451.

    Article  PubMed  CAS  Google Scholar 

  • Hanjan, S. N. S., Kearney, J. F., and Cooper, M. D., 1982, A monoclonal antibody (MMA) that identifies a differentiation antigen on human myelomonocytic cells, Clin. Immunol. Im munopa thol. 23: 172–188.

    Article  CAS  Google Scholar 

  • Haynes, B. F., Hemler, M. E., Mann, D. L., Eisenbarth, G. S., Shelhamer, J., Mostowski, H. S., Thomas, C. A., Strominger, J. L., and Fauci, A. S., 1981, Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes, J. Immunol. 126: 1409–1414.

    PubMed  CAS  Google Scholar 

  • Hercend, T., Reinherz, E. L., Meuer, S., Schlossman, S. F., and Ritz, J., 1983, Phenotypic and functional heterogeneity of human cloned natural killer cell lines, Nature 301:158-160.

    Google Scholar 

  • Hirsch, S., Austyn, J. M., and Gordon, S., 1981, Expression of the macrophage-specific antigen F4/80 during differentiation of mouse bone marrow cells in culture, J. Exp. Med. 154: 713–725.

    Article  PubMed  CAS  Google Scholar 

  • Ho, M. K., and Springer, T. A., 1983a, Tissue distribution, structural characterization specific antigen defined by monoclonal antibody, J. Immunol. 128: 1221–1228.

    Google Scholar 

  • Ho, M. K., and Springer, T. A., 1982b, Mac-1 antigen: Quantitative expression in macrophage populations and tissues, and immunofluorescent localization in spleen, J. Immunol. 128: 2281–2286.

    PubMed  CAS  Google Scholar 

  • Ho, M. K., and Springer, T. A., 1983a, Tissue of distribution, structural characterization and biosynthesis of Mac-3, a macrophage surface glycoprotein exhibiting molecular weight heterogeneity, J. Biol. Chem. 258: 636–642.

    PubMed  CAS  Google Scholar 

  • Ho, M. K., and Springer, T. A. 19836, Biosynthesis and assembly of the alpha and beta subunits of Mac-1, a macrophage glycoprotein associated with complement receptor function, J. Biol. Chem. 258: 2766–2769.

    Google Scholar 

  • Hoffman-Fezer, G., Gotze, D., Rodt, H., and Thierfelder, S., 1978, Immunohistochemical localization of xenogeneic antibodies against Iak lymphocytes on B cells and reticular cells, Immunogenetics 6: 367–375.

    Article  Google Scholar 

  • Hogg, N., 1983, Human monocytes are associated with the formation of fibrin, J. Exp. Med. 157: 473–485.

    Article  PubMed  CAS  Google Scholar 

  • Holmberg, L. A., Springer, T. A., and Ault, K. A., 1981, Natural killer activity in the peritoneal exudates of mice infected with Listeria monocytogenes: Characterization of the natural killer cells by using a monoclonal rat anti-murine macrophage antibody (M1/70), J. Immunol. 127: 1792–1799.

    PubMed  CAS  Google Scholar 

  • Huber, H., Douglas, S. D., and Fudenberg, H. H., 1969, The IgG receptor: An immunological marker for the characterization of mononuclear cells, Immunology 17: 7–21.

    PubMed  CAS  Google Scholar 

  • Humphrey, J. H., and Grennan, D., 1984, Isolation and properties of spleen follicular dendritic cells, Adv. Exp. Med.,(in press).

    Google Scholar 

  • Johnson, G. D., and Nogueira Araujo, G. M., 1981, A simple method of reducing the fading of immunofluorescence during microscopy, J. Immunol. Methods 43: 349–350.

    Article  PubMed  CAS  Google Scholar 

  • Jones, P. P., Murphy, D. B., Hewgill, D., and McDevitt, H. O., 1979, Detection of a common polypeptide chain in I-A and I-E subregion immunoprecipitates, Molec. Immunol. 16: 51–60.

    Article  Google Scholar 

  • Kaplan, G., and Gaudernack, G., 1982, In vitro differentiation of human monocytes. Differences in monocyte phenotypes induced by cultivation on glass or on collagen, J. Exp. Med. 156: 1101–1114.

    PubMed  CAS  Google Scholar 

  • Katz, H. R., LeBlanc, P. A., and Russell, S. W., 1981, An antigenic determinant shared by mononuclear phagocytes and mast cells, as defined by monoclonal antibody, J. Reticuloendothel. Soc. 30: 439–443.

    PubMed  CAS  Google Scholar 

  • Kiessling, R., Hochman, P. S., Haller, O., Shearer, G. M., Wigzell, H., and Cudkowicz, G., 1977, Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts, Eur. J. Immunol. 7: 655–663.

    Article  PubMed  CAS  Google Scholar 

  • Krensky, A. M., Ault, K. A., Reiss, C. S., Strominger, J. L., and Burakoff, S. J., 1982, Generation of long-term human cytolytic cell lines with persistent natural killer activity, J. Immunol. 129: 1748–1751.

    PubMed  CAS  Google Scholar 

  • Kulcyzycki, A., Jr., Solanki, L., and Cohen, L., 1981, Isolation and partial characterization of Fc gamma-binding proteins of human leukocytes, J. Clin. Invest. 68: 1158–1165.

    Article  Google Scholar 

  • Kurlander, R. J., and Batker, J., 1982, The binding of human immunoglobulin Gl monomer and small, covalently cross-linked polymers of immunoglobulin G1 to human peripheral blood monocytes and polymorphonuclear leukocytes, J. Clin. Invest. 69: 1–8.

    Article  PubMed  CAS  Google Scholar 

  • Kürzinger, K., and Springer, T. A., 1982, Purification and structural characterization of LFA-1, a lymphocyte function-associated antigen, and Mac-1, a related macrophage differentiation antigen, J. Biol. Chem. 257: 12412–12418.

    PubMed  Google Scholar 

  • Kürzinger, K., Reynolds, T., Germain, R. N., Davignon, D., Martz, E., and Springer, T. A., 1981, A novel lymphocyte function-associated antigen (LFA-1): Cellular distribution, quantitative expression, and structure, J. Immunol. 127: 596–602.

    PubMed  Google Scholar 

  • Kürzinger, K., Ho, M. K., and Springer, T. A., 1982, Structural homology of a macrophage differentiation antigen and an antigen involved in T-cell mediated killing, Nature 296: 668–670.

    Article  PubMed  Google Scholar 

  • Ladman, A. J., Padykula, H. A., and Strauss, E. W., 1963, A morphological study of fat transport in the normal human jejunum, Am. J. Anat. 112: 389–394.

    Article  PubMed  CAS  Google Scholar 

  • Lamers, M. C., Heckford, S. E., and Dickler, H. B., 1982, Monoclonal anti-Fc IgG receptor antibodies trigger B lymphocyte function, Nature 298: 178–180.

    Article  PubMed  CAS  Google Scholar 

  • Lane, B. C., and Cooper, S. M., 1982, Fc receptors of mouse cell lines. 1. Distinct proteins mediate the IgG subclass-specific Fc binding activities of macrophages, J. Immunol. 128: 1819–1824.

    PubMed  CAS  Google Scholar 

  • Lay, W. H., and Nussenzweig, V., 1968, Receptors for complement on leukocytes, J. Exp. Med. 128: 991–1009.

    Article  PubMed  CAS  Google Scholar 

  • Leblanc, P. A., Katz, H. R., and Russell, S. W., 1980, A discrete population of mononuclear phagocytes detected by monoclonal antibody, Infect. Immun. 8: 520–525.

    Google Scholar 

  • Letvin, N. L., Todd, R. F. III, Palley, L. S., Schlossman, S. F., and Griffin, J. D., 1983, Con- servation of myeloid surface antigens on primate granulocytes, Blood 61: 408–410.

    PubMed  CAS  Google Scholar 

  • Lichtshtein, D., Kaback, H. R., and Blume, A. J., 1979, Use of a lipophilic cation for determination of membrane potential in neuroblastoma-glioma hybrid cell suspension, Proc. Natl. Acad. Sci. USA 76: 650–654.

    Article  PubMed  CAS  Google Scholar 

  • Linker-Israeli, M., Billing, R. J., Foon, K. A., and Terasaki, P. I., 1981, Monoclonal anti- bodies reactive with acute myelogenous leukemia cells, J. Immunol. 127: 2473–2477.

    PubMed  CAS  Google Scholar 

  • Lohmeyer, J., Rieber, P., Feucht, H., Johnson, J., Hadam, M., and Riethmüller, G., 1981, A subset of human natural killer cells isolated and characterized by monoclonal antibodies, Eur. J. Immunol. 11: 997–1001.

    Article  PubMed  CAS  Google Scholar 

  • Loube, S. R., McNabb, T. C., and Dorrington, K. J., 1978, Isolation of an Fc gamma-binding proteins from detergent lysates and spent culture fluid of a macrophage-like cell line (P388D,), J. Immunol. 125: 970–975.

    Google Scholar 

  • Loube, S. R., McNabb, T. C., and Dorrington, K. J., 1978, Isolation of an Fc gamma-binding protein from the cell membrane of a macrophage-like cell line (P388D1) after detergent solubilization, J. Immunol. 120: 709–715.

    PubMed  CAS  Google Scholar 

  • McMaster, W. R., and Williams, A. F., 1979, Identification of Ia glycoproteins in rat thymus and purification from rat spleen, Eur. J. Immunol. 9: 426–433.

    Article  PubMed  CAS  Google Scholar 

  • Mason, D. W., Dallrnan, M., and Barclay, A. N., 1981, Graft-versus-host disease induces ex- pression of la antigen in rat epidermal cells and gut epithelium, Nature 293: 150–151.

    Article  PubMed  CAS  Google Scholar 

  • Matthews, T. J., Collins, J. J., Roloson, G. J., Thiel, H. J., and Bolognesi, D. P., 1981, Immunologic control of the ascites form of murine adenocarcinoma 755. IV. Characterization of the protective antibody in hyperimmune serum, J. Immunol. 126: 2332–2336.

    PubMed  CAS  Google Scholar 

  • Mellman, I. S., and Unkeless, J. C., 1980, Purification of a functional mouse Fc receptor through the use of a monoclonal antibody, J. Exp. Med. 152: 1048–1069.

    Article  PubMed  CAS  Google Scholar 

  • Mellman, I. S., Steinman, R. M., Unkeless, J. C., and Cohn, Z. A., 1980, Selective iodination and polypeptide composition of pinocytic vesicles, J. Cell. Biol. 86: 712–722.

    Article  PubMed  CAS  Google Scholar 

  • Mellman, I. S., Plutner, H., Steinman, R. M., Unkeless, J. C., and Cohn, Z. A., 1983, Internalization and degradation of macrophage Fc receptors during receptor-mediated phagocytosis, J. Cell. Biol. 96: 887–895.

    Article  PubMed  CAS  Google Scholar 

  • Messner, R. P., and Jelinek, J., 1970, Receptors for human gamma G globulin on human neutrophils, J. Clin. Invest. 49: 265–271.

    Article  Google Scholar 

  • Michl, J., Pieczonka, M. M., Unkeless, J. C., and Silverstein, S. C., 1979, Effects of immobilized immune complexes on Fc-and complement-receptor function in resident and thioglycollate-elicited mouse peritoneal macrophage, J. Exp. Med. 150: 607–621.

    Google Scholar 

  • Montal, M., and Miller, P., 1972, Formation of bimolecular membranes from lipid mono-layers and a study of their electrical properties, Proc. Natl. Acad. Sci. USA 69: 35613566.

    Google Scholar 

  • Muller, W. A., Steinman, R. M., and Cohn, Z. A., 1983, Membrane proteins of the vacuolar system. III. Further studies on the composition and recycling of endocytic vacuole membrane in cultured macrophages, J. Cell Biol. 96: 29–36.

    Article  PubMed  CAS  Google Scholar 

  • Nathan, C., Brukner, L., Kaplan, G., U:ikeless, J., and Cohn, Z., 1980, Role of activated macrophages in antibody-dependent lysis of tumor cells, J. Exp. Med. 152: 183–197.

    Google Scholar 

  • Nitta, T., and Suzuki, T., 1982, Biochemical signals transmitted by Fc gamma receptors:Triggering mechanisms of the increased synthesis of adenosine-3’,5’-cyclic monophosphate mediated by Fcy2a-and Fc72a_ receptors of a murine macrophage-like cell line (P388D1), J. Immunol. 129: 2708–2714.

    PubMed  CAS  Google Scholar 

  • Nussenzweig, M. C., Steinman, R. M., Unkeless, J. C., Witmer, M. D., Gutchinov, B., and Cohn, Z. A., 1981, Studies of the cell surface of mouse dendritic cells and other leukocytes, J. Exp. Med. 154: 168–187.

    Article  PubMed  CAS  Google Scholar 

  • Ortaldo, J. R., Sharrow, S. O., Timonen, T., and Herberman, R. B., 1981, Determination of surface antigens on highly purified human NK cells by flow cytometry with monoclonal antibodies, J. Immunol. 127: 2401–2409.

    PubMed  CAS  Google Scholar 

  • Peiris, J. S. M., Gordon, S., Unkeless, J. C., and Porterfield, J. S., 1981, Monoclonal antiFc receptor IgG blocks antibody enhancement of viral replication in macrophages, Nature 289: 189–191.

    Article  PubMed  CAS  Google Scholar 

  • Perlman, H., Perlman, P., Schreiber, R. D., and Muller-Eberhard, H. J., 1981, Interaction of target cell-bound C3bi and C3d with human lymphocyte receptors: Enhancement of antibody-mediated cellular cytotoxicity, J. Exp. Med. 153: 1592–1603.

    Article  Google Scholar 

  • Perussia, B., Trinchieri, G., Lebman, D., Jankiewicz, J., Lange, B., and Rovera, G., 1982, Monoclonal antibodies that detect differentiation surface antigens on human myelomonocytic cells, Blood 59: 382–392.

    PubMed  CAS  Google Scholar 

  • Perussia, B., Acuto, O., Terhorst, C., Faust, J., Lazarus, R., Fanning, V., and Trinchieri, G., 1983, Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. II. Studies of B73.1 antibody antigen interaction on the lymphocyte membrane, J. Immunol 130: 2142–2148.

    PubMed  CAS  Google Scholar 

  • Pober, J. S., and Gimbrone, M. A., Jr., 1982, Expression of la-like antigens by human vascular endothelial cells is inducible in vitro: Demonstration by monoclonal antibody binding and immunoprecipitation, Proc. Natl. Acad. Sci. USA 79: 6641–6645.

    Article  PubMed  CAS  Google Scholar 

  • Raff, H. V., Picker, L. J., and Stobo, J. D., 1980, Macrophage heterogeneity in man. A subpopulation of HLA-DR bearing macrophages required for antigen-induced T cell activation also contains stimulators for autologous-reactive T cells, J. Exp. Med. 152: 581–593.

    Article  PubMed  CAS  Google Scholar 

  • Ralph, P., Nakoinz, I., Diamond, B., and Yelton, D., 1980, All classes of murine IgG antibody mediate macrophage phagocytosis and lysis of erythrocytes, J. Immunol. 125: 1885–1888.

    PubMed  CAS  Google Scholar 

  • Ralph, P., Ho, M. K., Litcofsky, P. B., and Springer, T. A., 1983a, Expression and induction in vitro of macrophage differentiation antigens on murine cell lines, J. Immunol. 130: 108–114.

    PubMed  CAS  Google Scholar 

  • Ralph, P., Punjabi, C. J., Welte, K., Litcofsky, P. B., Ho, M. K., Moore, M. A. S., and Springer, T. A., 1983b, Lymphokine inducing “terminal differentiation” of the human monoblast leukemia line U937, Blood 62: 1169–1175.

    PubMed  CAS  Google Scholar 

  • Rosenberg, S. A., Ligler, F. S., Ugolini, V., and Lipsky, P. E., 1981, A monoclonal antibody that identifies human peripheral blood monocytes recognizes the accessory-cells required for mitogen-induced T lymphocyte proliferation, J. Immunol. 126: 1473–1477.

    PubMed  CAS  Google Scholar 

  • Ross, G. D., 1980, Analysis of the different types of leukocyte membrane complement receptors and their interaction with the complement system, J. Immunol. Methods 37: 197–211.

    Article  PubMed  CAS  Google Scholar 

  • Ross, G. D., and Lambris, J. D., 1982, Identification of a C3bi-specific membrane complement receptor that is expressed on lymphocytes, monocytes, neutrophils, and erythrocytes, J. Exp. Med. 155: 96–110.

    Article  PubMed  CAS  Google Scholar 

  • Ross, G. D., Newman, S. L., Lambris, J. D., Devery-Pocius, J. E., Cain, J. A., and Lachman, P. J., 1983, Generation of three different fragments of bound C3 with purified factor I or serum II. Location of binding sites in the C3 fragments for factors B and H, complement receptors, and bovine conglutinin, J. Exp. Med. 158: 334–352.

    Article  PubMed  CAS  Google Scholar 

  • Sanchez-Madrid, F., Nagy, J., Robbins, E., Simon, P., and Springer, T. A., 1983a, The human lymphocyte-function associated antigen (LFA-1), the C3bi complement recepfor (OKM1/Mac-1), and the p150,95 molecule: Characterization of a leukocyte differentiation antigen family with distinct alpha subunits and a common beta subunit, J. Exp. Med 158: 1785–1803.

    Article  PubMed  CAS  Google Scholar 

  • Sanchez-Madrid, F., Simon, P., Thompson, S., and Springer, T. A., 1983b, Mapping of antigenic and functional epitopes on the alpha and beta subunits of two related glycoproteins involved in cell interactions, LFA-1 and Mac-1, J. Exp. Med. 158: 586–602.

    Article  PubMed  CAS  Google Scholar 

  • Sarmiento, M., Loken, M. R., Trowbridge, I., Coffman, R. L., and Fitch, F. W., 1982, High molecular weight lymphocyte surface proteins are structurally related and are expressed on different cell populations at different times during lymphocyte maturation and differentiation, J. Immunol. 128: 1676–1684.

    PubMed  CAS  Google Scholar 

  • Scheid, M. P., and Triglia, D., 1979, Further description of the Ly-5 system, Immunogenetics 9: 423–433.

    Article  Google Scholar 

  • Schneider, R. J., Atkinson, J. P., Krause, V., and Kulczycki, A., Jr., 1981, Characterization of ligand-binding activity of isolated murine Fe y receptor, J. Immunol. 126: 735–740.

    PubMed  CAS  Google Scholar 

  • Schrader, J. W., Battye, F., and Scollay, R., 1982, Expression of Thy-1 antigen is not limited to T cells in cultures of mouse hemopoietic cells, Proc. Natl. Acad. Sci. USA 79: 4161–4165.

    Article  PubMed  CAS  Google Scholar 

  • Segal, D. M., and Titus, J. A., 1978, The subclass specificity for the binding of murine myeloma proteins to macrophage and lymphocyte cell lines and to normal spleen cells, J. Immunol. 120: 1395–1403.

    PubMed  CAS  Google Scholar 

  • Sheehy, M. J., Quintieri, F. B., Leung, D. Y. M., Geha, R. S., Dubey, D. P., Limmer, C. E., and Yunis, E. J., 1983, A human large granular lymphocyte clone with natural killer-like activity and T cell-like surface markers, J. Immunol. 130: 524–526.

    PubMed  CAS  Google Scholar 

  • Shen, H. H., Talle, M. A., Goldstein, G., and Chess, L., 1983, Functional subsets of human monocytes defined by monoclonal antibodies: A distinct subset of monocytes contains the cells capable of inducing the autologous mixed lymphocyte culture, J. Immunol. 130: 698–705.

    PubMed  CAS  Google Scholar 

  • Silberberg-Sinakin, I., Thorbecke, G. J., Baer, R. L., Rosenthal, S. A., and Berezowsky, V., 1976, Antigen-bearing Langerhans cells in skin, dermal lymphatics and in lymph nodes, Cellular Immunol. 25: 137–151.

    Article  CAS  Google Scholar 

  • Smith, B. R. Springer, T. A., Rosenthal, D. S., and Ault, K. A., 1984, Distribution of the myeloid surface antigen Mac-1 on normal and leukemic human cells, Blood (submitted for publication).

    Google Scholar 

  • Springer, T. A., 1980, Cell-surface differentiation in the mouse. Characterization of “jumping” and “lineage” antigens using xenogeneic rat monoclonal antibodies, in: Monoclonal Antibodies ( R. H. Kennett, T. J. McKearn, and K. K. Bechtol, eds.), pp. 185–217, Plenum Press, New York.

    Chapter  Google Scholar 

  • Springer, T. A., 1981, Mac-1,2,3, and 4: Murine macrophage differentiation antigens identified by monoclonal antibodies, in: Heterogeneity of Mononuclear Phagocytes ( O. Förster and M. Landy, eds.), pp. 37–46, Academic Press, New York.

    Google Scholar 

  • Springer, T. A., Galfre, G., Secher, D. S., and Milstein, C., 1979, Mac-1: A macrophage dif- ferentiation antigen identified by monoclonal antibody, Eur. J. Immunol. 9: 301–306.

    Article  PubMed  CAS  Google Scholar 

  • Springer, T. A., Davignon, D., Ho, M. K., Kürzinger, K., Martz, E., and Sanchez-Madrid, F., 1982, LFA-1 and Lyt-2,3, molecules associated with T lymphocyte-mediated killing; and Mac-1, an LFA-1 homologue associated with complement receptor function, Immunol. Rev. 68: 111–135.

    Article  Google Scholar 

  • Steinman, R. M., and Cohn, Z. A., 1973, Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution, J. Exp. Med. 137: 1142–1162.

    Article  PubMed  CAS  Google Scholar 

  • Steinman, R. M., and Cohn, Z. A., 1974, Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro, J. Exp. Med. 139: 380–397.

    Article  PubMed  CAS  Google Scholar 

  • Steinman, R. M., Kaplan, G., Witmer, M. D., and Cohn, Z. A., 1979, Identification of a novel cell type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro, J. Exp. Med. 149: 1–16.

    Article  PubMed  CAS  Google Scholar 

  • Stings, G., Katz, S. I., Clement, L., Green, I., and Shevach, E., 1978, Immunologic functions of la-bearing epidermal Langerhans cells, J. Immunol. 121: 2005–2113.

    Google Scholar 

  • Sun, D., and Lohmann-Matthes, M. L., 1982, Functionally different subpopulations of mouse macrophages recognized by monoclonal antibodies, Eur. J. Immunol. 12: 134140.

    Google Scholar 

  • Swartz, R. H., Dickler, H. B., Sachs, D. H., and Schwartz, B. D., 1976, Studies of la antigens on murine peritoneal macrophages, Scand. J. Immunol. 5: 731–743.

    Article  Google Scholar 

  • Tamaki, K., Stingl, G., Gullino, M., Sachs, D. H., and Katz, S. I., 1979, la antigens in mouse skin are predominantly expressed on Langerhans cells, J. Immunol. 123: 784–787.

    Google Scholar 

  • Taniyama, T., and Watanabe, T., 1982, Establishment of a hybridoma secreting a monoclonal antibody specific for activated tumoricidal macrophages, J. Exp. Med. 156: 1286 1291.

    Google Scholar 

  • Tew, J. G., Thorbeck, G. J., and Steinman, R. M., 1982, Dendritic cells in the immune response: Characteristics and recommended nomenclature (a report from the Reticuloendothelial Society Committee on Nomenclature), J. Reticuloendothel. Soc. 31: 371–380.

    PubMed  CAS  Google Scholar 

  • Thorbecke, G. J., Silberberg-Sinakin, E., and Flotte, T. J., 1980, Langerhans cells as macrophages in skin and lymphoid organs, J. Invest. Dermatol. 75: 32–43.

    Article  PubMed  CAS  Google Scholar 

  • Todd, R. F. III, and Schlossman, S. F., 1982, Analysis of antigenic determinants on human monocytes and macrophages, Blood 59: 775–786.

    PubMed  CAS  Google Scholar 

  • Todd, R. F. III, and Schlossman, S. F., 1984, Utilization of monoclonal antibodies in the characterization of monocyte-macrophage differentiation antigens, in: The Reticuloendothelial System: A Comprehensive Treatise, Vol. 6: Immunology (J. A. Bellanti and H. B. Herscowitz, eds.), pp. 87–1 11, Plenum Press, New York.

    Google Scholar 

  • Todd, R. F. III, Nadler, L. M., and Schlossman, S. F., 1981, Antigens on human monocytes identified by monoclonal antibodies, J. Immunol. 126: 1435–1442.

    PubMed  Google Scholar 

  • Todd, R. F. III, Van Agthoven, A., Schlossman, S. F., and Terhorst, C., 1982, Structural analysis of differentiation antigens Mol and Mo2 on human monocytes, Hybridoma 1: 329–337.

    Article  PubMed  CAS  Google Scholar 

  • Todd, R. F. III, Bhan, A. K., Kabawat, S. E., and Schlossman, S. F., 1984, Human myelomonocytic differentiation antigens defined by monoclonal antibodies, in: HumanLeukocyte Markers Detected by Monoclonal Antibodies (A. Bernard, L. Boumsell, J.Dausset, C. Milstein, and S. F. Schlossman, eds.), Springer-Verlag, Berlin (in press). Townsend, R., and Stahl, P., 1981, Isolation and characterization of a mannose/N-acetylglucosamine/fucose-binding protein from rat liver, Biochem. J. 194:209–214.

    Google Scholar 

  • Trowbridge, I. S., and Omary, M. B., 1981, Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1, J. Exp. Med. 154: 1517–1524.

    Article  PubMed  CAS  Google Scholar 

  • Ugolini, V., Nunez, G., Smith, R. G., Stastny, P., and Capra, J. D., 1980, Initial characterization of monoclonal antibodies against human monocytes, Proc. Natl. Acad. Sci. USA. 77: 6764–6768.

    Article  PubMed  CAS  Google Scholar 

  • Unanue, E. R., 1981, The regulatory role of macrophages in antigenic stimulation. Part Two. Symbiotic relationship between lymphocytes and macrophages, Adv. Immunol. 31: 1–136.

    Article  PubMed  CAS  Google Scholar 

  • Unkeless, J., 1979, Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors, J. Exp. Med. 150: 580–596.

    Article  PubMed  CAS  Google Scholar 

  • Unkeless, J. C., and Eisen, H. N., 1975, Binding of monomeric immunoglobulins to Fc receptors of mouse macrophages, J. Exp. Med. 142: 1520–1533.

    Article  PubMed  CAS  Google Scholar 

  • Unkeless, J. C., Fleit, H., and Mellman, I. S., 1981, Structural aspects and heterogeneity of immunoglobulin Fc receptors, in: Advances in Immunology, Vol. 31 ( F. J. Dixon and H. G. Kunkel, eds.), pp. 247–270, Academic Press, New York.

    Google Scholar 

  • Van Der Reijden, H. J., Van Rhenen, D. J., Lansdorp, P. M., Van’t Veer, M. B., Langenhuijsen, M. M. A. C., Engelfriet, C. P., and Von Dem Borne, A. E. C. K., 1983, A comparison of surface marker analysis and FAB classification in acute myeloid leukemia, Blood 61: 443–448.

    PubMed  Google Scholar 

  • Van Voorhis, W. C., Hair, L. S., Steinman, R. M., and Kaplan, G., 1982, Human dendritic cells. Enrichment and characterization from peripheral blood, J. Exp. Med. 155: 1172–1187.

    Article  PubMed  Google Scholar 

  • Walker, W. S., 1976, Separate Fc receptors for immunoglobulins IgG2a and IgG2b on an established cell line of mouse macrophages, J. Immunol. 116: 911–914.

    PubMed  CAS  Google Scholar 

  • Wright, S. D, and Silverstein, S. C., 1982, Tumor-promoting phorbol esters stimulate Cab and C3b1 receptor-mediated phagocytosis in cultured human monocytes, J. Exp. Med. 156: 1149–1164.

    Article  PubMed  CAS  Google Scholar 

  • Wright, S. D., Van Voorhis, W. C., and Silverstein, S. C., 1983, Identification of the C3b’receptor on human leukocytes using a monoclonal antibody, Fed. Proc. 42: 1079.

    Google Scholar 

  • Yoshie, O., Mellman, I. S., Broeze, R. J., Garcia-Blanco, M., and Lengyel, P., 1982, Interferon action: Effects of mouse alpha and beta interferons on rosette formation, phagocytosis, and surface-antigen expression of cells of the macrophage-type line RAWCr.1, Cell. Immunol. 73: 128–140.

    Article  PubMed  CAS  Google Scholar 

  • Young, J. D. E., Unkeless, J. C., Kaback, H. R., and Cohn, Z. A., 1983a, Macrophage membrane potential changes associated with y2b/IFc receptor-ligand binding, Proc. Natl. Acad. Sci. USA. 80: 1357–1361.

    Article  PubMed  CAS  Google Scholar 

  • Young, J. D. E., Unkeless, J. C., Kaback, H. R., and Cohn, Z. A., 1983b, Mouse macrophage Fc receptor for IgG y2b/7l in artificial and plasma membrane vesicles functions as a ligand-dependent ionophore, Proc. Natl. Acad. Sci. USA 80: 1636–1640.

    Article  PubMed  CAS  Google Scholar 

  • Zarling, J. M., Clouse, K. A., Biddison, W. E., and Kung, P. C., 1981, Phenotypes of human natural killer cell populations detected with monoclonal antibodies, J. Immunol. 127: 2575–2580.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer Science+Business Media New York

About this chapter

Cite this chapter

Springer, T.A., Unkeless, J.C. (1984). Analysis of Macrophage Differentiation and Function with Monoclonal Antibodies. In: Adams, D.O., Hanna, M.G. (eds) Macrophage Activation. Contemporary Topics in Immunobiology, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1445-6_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-1445-6_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1447-0

  • Online ISBN: 978-1-4757-1445-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics