Abstract
In recent years there has been an appreciable expansion of our understanding of secondary hyperuricemia and of certain rare subtypes of gout associated with an excessive production of uric acid. Although the pathogenesis of primary hyperuricemia in most subjects remains obscure, it is clear that many such patients have a diminished renal clearance of uric acid (Wyngaarden and Kelley, 1972). The factor(s) responsible for this abnormal clearance has been difficult to define since our understanding of the manner in which the kidney of normal man regulates uric acid excretion is incomplete.
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Postlethwaite, A.E., Ramsdell, C.M., Kelley, W.N. (1974). Uricosuric Effect of an Anticholinergic Agent in Hyperuricemic Subjects. In: Sperling, O., De Vries, A., Wyngaarden, J.B. (eds) Purine Metabolism in Man. Advances in Experimental Medicine and Biology, vol 41. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-1433-3_53
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DOI: https://doi.org/10.1007/978-1-4757-1433-3_53
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