Abstract
Estrogens play an important role in the genesis of experimental and human breast cancers1,2. Once established, the tumors are frequently hormone-dependent, i.e. they regress or stop growing if deprived of estrogen3. in humans, about one-third of advanced breast cancers are thus susceptible to remission with endocrine therapy4. Criteria for the selection of patients that will respond to hormonal treatment have been the subject of intense study during the last 2 decades5. On the molecular level this had led to the development of analytical tools for the study of steroid receptors and steroid-induced proteins.
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References
T.L. Dao, 1964, Carcinogenesis of mammary gland in rat. Prog. Exp. Tumor Res., 5:157.
B.E. Henderson, R.K. Ross, M.C. Pike, and J.T. Casagrande, 1982, Endogenous hormones as a major factor in human cancer. Cancer Res., 42:3239.
G.T. Beatson, 1896, On the treatment of inoperable cases of carcinoma of the mamma: Suggestions for a new method of treatment with illustrative cases. Lance., ii:104.
E. V. Jensen, and E.R. DeSombre, 1977, The diagnostic implications of steroid binding in malignant tissues. Adv. Clin. Chem., 19:57.
J.C. Henderson, and G.P. Canellos, 1980, Cancer of the breast. The past decade. N. Engl. J. Med., 302:17.
G.L. Greene, C. Nolan, J.P. Engler, E. V. Jensen, 1980, Monoclonal antibodies to human estrogen receptor. Proc. Natl. Acad. Sci. USA., 77:5115.
F. Logeat, M.T. Vu Hai, A. Fournier, P. Legrain, G. Buttin, and E. Milgrom, 1983, Monoclonal antibodies to rabbit progesterone receptor: crossreaction with other mammalian progesterone receptors. Proc. Natl. Acad. Sci. USA., 80:6456.
W.J. King, and G.L. Greene, 1984, Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells. Natur., 307:745.
M. Perrot-Applanat, F. Logeat, M.T. Groyer-Picard, and E. Milgrom, 1985, Immunocytochemical study of mammalian progesterone receptor using monoclonal antibodies. Endocrinology, 116:1473.
W.J. King, E.R. DeSombre, E.V. Jensen, and G.L. Greene, 1985, Comparison of immunocytochemical and steroid-binding assays for estrogen receptor in human breast tumors. Cancer Res.,45:293.
M. Perrot-Appianat, M. T. Uroyer-Picard, F. Lorenzo, A. Jolivet, M.T. Vu Hai, C. Pallud, F. Spyratos, and E. Milgrom, 1987, Immunocytochemical study with monoclonal antibodies to progesterone receptor in human breast tumors. Cancer Res., 47:2652.
F. Lorenzo, A. Jolivet, H. Loosfelt, M.T. Vu Hai, S. Brailly, M. Perrot-Applanat, and E. Milgrom, 1988, A rapid method of epitope mapping. Application to the study of immunogenic domains and to the characterization of various “forms” of rabbit progesterone receptor. Eur. J. Biochem., 176:53.
M.T. Vu Hai, A. Jolivet, V. Ravet, F. Lorenzo, M. Perrot-Applanat, M. Citerne, and E. Milgrom, 1988, Novel monoclonal antibodies against human uterine progesterone receptor. Mapping of receptor immunogenic domains. Submitted for publication.
E. Garcia, P. Bouchard, J. De Brux, J. Berdah, R. Frydman, G. Schaison, E. Milgrom, and M. Perrot-Applanat, 1988, Use of immunocytochemistry of progesterone and estrogen receptors for endometrial dating. J. Clin. Endocrinol. Metab., 67:80.
P. Masiakowski, R. Breathnach, J. Bloch, F. Gannon, A. Krust, and P. Chambon, 1982, Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human br eas t cancer cell line. Nucleic Acids Res., 24:7895.
J.F. Prud’homme, F. Fridlansky, M. Le Cunff, M. Atger, C. Mercier-Bodard, M.F. Pichon, and E. Milgrom, 1985, Cloning of a gene expressed in human breast cancer and regulated by estrogen in MCF-7 cells. DN., 4:11.
S.B. Jakowlev, R. Breathnach, R. Jeltsch, J.M. Masiakowski, and P. Chambon, 1984, Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7. Nucleic Acids Res., 12:2861.
H. Loosfelt, M. Atger, M. Misrahi, A. Guiochon-Mantel, C. Mériel, F. Logeat, R. Bénarous, and E. Milgrom, 1986, Cloning and sequence analysis of rabbit progesterone-receptor complementary DNA. Proc. Natl. Acad. Sci. USA., 83:9045.
H. Loosfelt, F. Logeat, M.T. Vu Hai, and E. Milgrom, 1984, The rabbit progesterone receptor. Evidence for a single steroid-binding subunit and characterization of receptor mRNA. J. Biol. Chem., 259:14196.
F. Logeat, R. Pamphile, H. Loosfelt, A. Jolivet, A. Fournier, and E. Milgrom, 1985, One-step immunoaffinity purification of active progesterone receptor. Further evidence in favor of the existence of a single steroid binding subunit. Biochemistr., 24:1029.
H. J. G. Bloom, and W.W. Richardson, 1957, Histological grading and prognosis in breast cancer. Br. J. Cancer, 11:359.
EORTC Breast Cancer Cooperative Group. 1980, Revision of the standards for the assessement of hormone receptors in human breast cancer. Eur. J. Cancer. 16:1513.
T.K. Mayer, and R.A. Mooney, 1988, Laboratory analyses for steroid hormone receptors, and their applications to clinical medicine. Clinica Chimica Act., 172:1.
I.P. Shintaku, and J.W. Said, 1987, Detection of estrogen receptors with monoclonal antibodies in routinely processed formalin-fixed paraffin sections of breast carcinoma. Am. J. Clin. Pathol. 87:161.
U. Ruther, and B. Muller-Hill, 1983, Easy identification of cDNA clones. EMBO J., 2:1791.
F. E. B. May, and B.R. Westley, 1986, Cloning of estrogen-regulated messenger RNA sequences from human breast cancer cells. Cancer Res., 46:6034.
A.M. Nunez, S. Jakowlev, J.P. Briand, D. Gaire, A. Krust, M.C. Rio, and P. Chambon, 1987, Characterization of the estrogen-induced pS2 protein secreted by the human breast cancer cell line MCF-7. Endocr inolog., 121:1759.
A. M. C. Brown, J. M. Jeltsch, M. Roberts, and P. Chambon, 1984, Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7. Proc. Natl. Acad. Sci. USA., 81:6344.
M.E. Baker, 1988, Estrogen-induced pS2 protein is similar to pancreatic spasmolytic polypeptide and the kringle domain. Biochem. J., 253:307.
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Perrot-Applanat, M., Prud’homme, JF., Hai, MT.V., Jolivet, A., Lorenzo, F., Milgrom, E. (1989). Monoclonal Antibodies Against Steroid Receptors and Steroid-Induced Proteins. In: Ceriani, R.L. (eds) Breast Cancer Immunodiagnosis and Immunotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1296-4_12
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DOI: https://doi.org/10.1007/978-1-4757-1296-4_12
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