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The Potential of Synthetic Tumor-Associated Glycoconjugates (S-TAGs) for Generating Monoclonal Antibodies for Breast Cancer Imaging and for Specific Immunotherapy

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Breast Cancer Immunodiagnosis and Immunotherapy

Abstract

The Thomsen Friedenreich (TF) antigen may be important for the detection and immunotherapy of a number of common cancers including breast cancer. Revealed on normal human erythrocytes by neuraminidase treatment, TF has been characterized as: β-D-Gal-(1–3)- α-GalNAc, attached to glycophorin or other glycoproteins through O-serine or O-threonine linkages (1). Tn, the TF precursor, is reported to be α-GalNAc-O-serine/ threonine. While TF is normally cryptic due to the presence of a terminal sialic acid residue, Tn is exposed in individuals with a recessive genetic disorder (2). Springer (1) has claimed expression of TF and Tn antigens on over 90% of cancers of the breast, lung and pancreas, although the nature of the molecules which bear these antigens and their exact structures has not been defined.

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Author information

Authors and Affiliations

  1. Departments of Medicine, University of Alberta, Edmonton, Alberta, Canada

    Grant MacLean

  2. Departments of Nuclear Medicine, University of Alberta, Edmonton, Alberta, Canada

    Alexander McEwan

  3. Cross Cancer Institute Departments of Medicine, University of Alberta, Edmonton, Alberta, Canada

    Grant MacLean

  4. Departments of Immunology, University of Alberta, Edmonton, Alberta, Canada

    Eleanor Mackie, Peter Fung, Carina Henningsson & Michael Longenecker

  5. Faculty of Medicine, and Faculty of Pharmacy, University of Alberta, Edmonton, Alberta, Canada

    Eleanor Mackie, Peter Fung, Rao Koganty, Marian Madej, Thomas Sykes, Antoine Noujaim & Michael Longenecker

  6. Biomira Inc., Edmonton, Alberta, Canada

    Antoine Noujaim

Authors
  1. Grant MacLean
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  2. Alexander McEwan
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  3. Eleanor Mackie
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  4. Peter Fung
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  5. Carina Henningsson
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  6. Rao Koganty
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  7. Marian Madej
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  8. Thomas Sykes
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  9. Antoine Noujaim
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  10. Michael Longenecker
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Editor information

Editors and Affiliations

  1. John Muir Cancer and Aging Research Institute, Walnut Creek, California, USA

    Roberto L. Ceriani

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© 1989 Springer Science+Business Media New York

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MacLean, G. et al. (1989). The Potential of Synthetic Tumor-Associated Glycoconjugates (S-TAGs) for Generating Monoclonal Antibodies for Breast Cancer Imaging and for Specific Immunotherapy. In: Ceriani, R.L. (eds) Breast Cancer Immunodiagnosis and Immunotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1296-4_1

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  • DOI: https://doi.org/10.1007/978-1-4757-1296-4_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1298-8

  • Online ISBN: 978-1-4757-1296-4

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