Abstract
It has been reported occasionally that the incidence of neoplasia among invertebrate animals is lower than that seen among mammalian species. It is unclear if this is true or if this is a result of lack of data, or some unique feature of invertebrate biology. Since many chemical carcinogens require metabolic activation before they can express their biological activities, lack of the enzymes which mediate these reactions could supply a basis to support the theory that invertebrates are resistant to cancer. Therefore, this laboratory initiated comparative studies of aryl hydrocarbon hydroxylase (AHH) activity in lower animals using benzo [a] pyrene (BP) as substrate.
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Abramson, R. K. and Hutton, J. J. (1975). Ef f ects of cigarette smoking on aryl hydrocarbon hydroxylase activity in lungs and tissues of inbred mice. Cancer Res., 35, 23–29.
Agosin, M., Scaramelli, N., Gil, L. and Letelier, M. E. (1969) . Some properties of microsomal system metabolizing DDT in Triatoma infestans. Conmp. Biochem. Physiol., 29, 785–793.
Allen, J. R. and Abrahamson, L. J. (1973). Morphological and biochemical changes in the livers of rats fed polychlorinated biphenyls. Arch. Environ. Contam. Toxicol., 1, 265–280.
Bickers, D. R., Eiseman, J., Kappas, A. and Alvares, A. P. (1975) . Microscope immersion oils: Ef f ects of skin application on cutaneous and hepatic drug-metabolizing enzymes. Biochem. Pharmacol., 24, 779–783.
Brattsten, L. B. and Wilkinson, C. F. (1973). A microsomal enzyme inhibitor in the gut contents of the house cricket (Acheta domesticus) . Comp. Biochem. Physiol., 45B, 59–70.
Brown, R. S., Wolke, R. E., Brown, C. W. and Saila, S. B. (1977) . Hydrocarbon pollution and the prevalence of neoplasia in feral soft-shell clams, Mya arenaria. Proc. Symp. Environmental Pollutants, University of Connecticut, Storrs, Conn. In press.
Chakraborty, J. and Smith, J. N. (1967) . Enzymic oxidation of some alkyl-benzenes in insects and vertebrates. Biochem. J., 102, 498–503.
Chen, T. S. and DuBois, K. P. (1973) . Studies on the enzyme inducing effect of polychlorinated biphenyls. Toxicol. App l. Pharmacol., 26, 504 –512.
Dunn, B. P. and Stich, H. F. (1975) . The use of mussels in estimating benzo [a] pyrene contamination of the marine environment. Proc. Soc. Exp. Biol. Med., 150, 49–51.
Gil, D. L., Rose, H. A., Yang, R. S. H., Young, R. G. and Wilkinson, C. F. (1974) . Enzyme induction by phenobarbital in the Madagascar cockroach, Gromphadorhina portentosa. Comp. Biochem. Physiol., 47B, 657–662.
Gil, L., Fine, B. C., Dinamarca, M. L., Balazs, I., Busvine, J.R. and Agosin, M. (1968) . Biochemical studies on insecticide resistance in Musca domestica. Entomol Exp. Appl., 11, 15–29.
Goldstein, J. C., Hickman, P., Bergman, H., McKinney, J. D. and Walker, M. P. (1977) . Separation of pure polychlorinated biphenyl isomers into two types of inducers on the basis of induction of cytochrome P-450 or P-448. Chem.-Biol. Interact., 17, 69–87.
Grote, W., Schmoldt, A. and Dammann, H. G. (1975). The metabolism of foreign compounds in rats after treatment with polychlorinated biphenyls (PCBs) . Biochem. Pharmacol., 24, 1121–1125.
Khan, M. A. Q. and Matsumura, F. (1972) . Induction of mixedfunction oxidase and protein synthesis by DDT and dieldrin in German and American cockroaches. Pestic. Biochem. Physiol., 2, 236–243.
Krieger, R. I., Feeny, P. P. and Wilkinson, C. F. (1971) . Detoxication enzymes in the guts of caterpillars: An evolut ionary answer to plant defenses? Science 172, 579–581.
Krieger, R. I. and Lee, P. W. (1973) . Properties of the aldrin epoxidase system in the gut and fat body of a caddisfly larva. J. Econ. Entomol., 66, 1–6.
Krieger, R. I. and Wilkinson, C. F. (1969) . Microsomal mixedfunction oxidases in insects. I. Localization and properties of an enzyme system ef f ecting aldrin epoxidation in larvae of the Southern Armyworm (Prodenia eridania) . Biochem. Pharmacol., 18, 1403–1415.
Krieger, R. I. and Wilkinson, C. F. (1970) . An endogenous inhibitor of microsomal mixed-function oxidase in homogenates of the Southern Armyworm (Prodenia eridania). Biochem. J., 116, 781–789.
Lee, R. F., Sauerheber, R. and Dobbs, G. H. (1972) . Uptake, metabolism and discharge of polycyclic aromatic hydrocarbons by marine fish. Marine Biol., 17, 201–208.
Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951) . Protein measurement with Folin phenol reagent. J. Biol. Chem. 193, 265–275.
Meksongsee, B., Yang, R. S. and Guthrie, F. E. (1967) . Effects of inhibitors and inducers of microsomal enzymes on the toxicity of carbamate insecticides to mice and insects. J. Econ. Entomol., 60, 1469–1471.
Morello, A. (1964) . Role of DDT-hydroxylation in resistance. Nature 203, 785 –786.
Nebert, D. W. and Gelboin, H. V. (1968) . Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. J. Biol. Chem. 243, 6242–6249.
Oppenoorth, F. J. and Houx, N. W. H. (1968). DDT resistance in the housefly caused by microsomal degradation. Entomol. Exp. Appl. 11, 81–93.
Payne, J. F. (1976) . Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution. Science 191, 945–946.
Perry, A. S. and Buckner, A. J. (1970). Microsomal cytochrome P-450 in resistant and susceptible housef lies . Life Sci.,9, 335–350.
Plapp, F. W., Jr. and Casida, J. E. (1970) . Induction by DDT and dieldrin of insecticide metabolism by housefly enzymes. J. Econ. Entomol., 63, 1091–1092.
Ray, J. W. (1967) . The epoxidation of aldrin by housefly microsomes and its inhib it ion by carbon monoxide. Biochem. Pharmacol., 16, 99–107.
Rhee, K. S. and Plapp, F. W. Jr. (1973) . Polychlorinated biphenyls (PCBs) as inducers of microsomal enzyme activity in the housefly. Arch. Environ. Contam. Toxicol., 1, 182–192.
Schonbrod, R. D. and Terriere, L. C. (1971) . Eye pigments as inhibitors of microsomal aldrin epoxidase in the housefly. J. Econ. Entomol., 64, 44–45.
Vandermeulen, J. H., Keizer, P. D. and Penrose, W. R. (1977) . Persistance of non-alkane components of bunker C oil in beach sediments of Chedabucto Bay, and their lack of metabolism by molluscs. Proc. 1977 Oil Spill Conference. American Petroleum Institute publication No. 4284, pp. 469–473.
Yevich, P. P. and Barszcz, C. (1976). Gonadal and hematopoietic neoplasms in Mya arenaria. Mar. Fish. Rev., 38, 42–43.
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Anderson, R.S. (1978). Developing an Invertebrate Model for Chemical Carcinogenesis: Metabolic Activation of Carcinogens. In: Bulla, L.A., Cheng, T.C. (eds) Invertebrate Models for Biomedical Research. Comparative Pathobiology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1278-0_2
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DOI: https://doi.org/10.1007/978-1-4757-1278-0_2
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