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Chronic Effects of Drugs on Airway Mucus-Secreting Cells

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Drugs and the Lung

Part of the book series: Ettore Majorana International Science Series ((EMISS,volume 14))

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Abstract

Atmospheric pollution and, in particular, personal pollution by tobacco smoke (T.S.) is a major cause of chronic inflammation of the tracheo-bronchial mucous membrane (Royal College of Physicians, 1977). In man there is an increase in the number of mucus-secreting cells both in the surface epithelium and in submucosal glands (resulting in gland hypertrophy). The clinical consequences are recurrent cough and the excessive production of airways’ mucus which is expectorated as sputum (Reid 1954). Small airways, normally without mucus-secreting cells, are also affected and show secretory cell metaplasia, a bronchiolitis and smooth muscle hypertrophy (Hogg et al, 1968; Cosio et al, 1980). Thus whilst the contribution to sec re to ry cell increase by surface and gland cells is greatest in the largest airways, the secretory cell metaplasia seen in the epithelium of bronchioli probably has the greater functional implications (Hogg et al, 1968; Thurlbeck et al, 1975).

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Authors and Affiliations

  1. Department of Lung Pathology, Cardiothoracic Institute, Brompton Hospital, London, UK

    P. K. Jeffery, D. F. Rogers, M. Ayres, P. M. Evans & D. A. William

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  1. P. K. Jeffery
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  2. D. F. Rogers
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  3. M. Ayres
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  4. P. M. Evans
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  5. D. A. William
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Editors and Affiliations

  1. The Midhurst Medical Research Institute, Midhurst, West Sussex, UK

    Gordon Cumming

  2. University of Palermo, Palermo, Italy

    Giovanni Bonsignore

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Jeffery, P.K., Rogers, D.F., Ayres, M., Evans, P.M., William, D.A. (1984). Chronic Effects of Drugs on Airway Mucus-Secreting Cells. In: Cumming, G., Bonsignore, G. (eds) Drugs and the Lung. Ettore Majorana International Science Series, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1269-8_6

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  • DOI: https://doi.org/10.1007/978-1-4757-1269-8_6

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