Abstract
The activation of ras oncogenes has been clearly implicated in the tumorigenic process, being the oncogene most frequently identified in human cancers. (Barbacid 1985). Ras genes containing point mutations as well as amplified genes leading to over-expression of the protein product p21 have been found in human tumours (Der et al 1982, Bos et al 1986). There is, however, no reason to assume that we have yet identified all of the genetic changes involved or indeed that they are necessarily the primary events in tumorigenesis.
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Hawley, P., Gibson, I. (1989). Suppression of ras Oncogene Expression Using Sequence Specific Oligodeoxynucleotides. In: Spandidos, D. (eds) ras Oncogenes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1235-3_23
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DOI: https://doi.org/10.1007/978-1-4757-1235-3_23
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