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Weak Linkage Between HIV Epidemics in Homosexual Men and Intravenous Drug Users

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Summary

Since homosexual men who are also intravenous drug users interact sexually with homosexual men and share needles with intravenous drug users, they are a potential transfer linkage between the HIV epidemics in homosexual men and intravenous drug users. One theory is that these HIV epidemics are not crucially linked by homosexual intravenous drug users so that neither epidemic is feeding or sustaining the other. A simulation model with HIV transmission and progression to AIDS is formulated for three risk groups. Evidence based on fitting this model to AIDS incidence data in New York City supports the theory that neither HIV epidemic sustains the other. Thus the HIV epidemics in homosexual men and intravenous drug users are only weakly linked and can be modeled as separate epidemics.

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References

  • Bacchetti, P. and Moss, A.R. (1989). Incubation period of AIDS in San Francisco. Nature 338, 251–53.

    Article  PubMed  CAS  Google Scholar 

  • Battjes, R. J., Pickens, R. W., Amsel, Z. (1989). Introduction of HIV infection among intravenous drug abusers in low prevalence areas. J. AIDS 2, 533–539.

    CAS  Google Scholar 

  • Black, J.L. Dolan, M.P. and DeFord, H.A., et al. (1986). Sharing of needles among users of iv drugs. New England Journal of Medicine 314 446–447.

    Google Scholar 

  • Blower, S.M., Hartel, D., Dowlatabadi, H., et al. (1991). Drugs, sex and HIV: A mathematical model for New York City. Phil Trans R Soc Lond B 321, 171–187.

    Google Scholar 

  • Blythe, S.P. and Anderson, R.M. (1988). Heterogeneous sexual activity model of HIV transmission in male homosexual populations. IMA Journal of Math App Med Biol 5, 237–260.

    Article  CAS  Google Scholar 

  • Blythe, S.P. and Castillo-Chavez, C. (1989). Like with like preference and sexual mixing models. Math Biosci 96, 221–238.

    Google Scholar 

  • Burke, D.S., Redfield, R.R., Fowler, A., Oster, C. (1989). Increased “viral burden” in late stages of HIV infection. Abstract Th.A.P.93, V International Conference on AIDS, Montreal, Canada.

    Google Scholar 

  • Castillo-Chavez, C., Cooke, K.L., Huang, W., and Levin, S.A. (1989). On the role of long incubation periods in the dynamics of AIDS Part 2: Multiple group models, Math and Stat Approaches to AIDS Epidemiology, In Lecture Note in Biomathematics 83, C Castillo-Chavez (eds). Springer- Verlag, New York, Berlin, Heidelberg, pp. 200–217.

    Google Scholar 

  • Cates, W., Jr. and Handsfield, H.H. (1988). HIV counseling and testing: does it work? AJPH, 78, 1533–34.

    Article  Google Scholar 

  • Centers for Disease Control. (1989). Update: Acquired Immunodeficiency Syndrome-United States. MMWR, No. 5, 39, 81–86.

    Google Scholar 

  • Centers for Disease Control. (1990b). Update: HIV prevalence estimates and AIDS case projections for the United States: Report based on a workshop. MMWR, No. RR-16, 39, 1–31.

    Google Scholar 

  • Coates, T.J., Morin, S.F., McKusick, L. (1987). Behavioral consequences of AIDS antibody testing among gay men. JAMA 258, 1889.

    Article  PubMed  CAS  Google Scholar 

  • Curran, J.W., Jaffe, H.W., Hardy, A.M., Morgan, W.M., Selik, R.M., Dondero, T.J. (1988). Epidemiology of HIV infection and AIDS in the United States. Science 239, 610–16.

    Article  PubMed  CAS  Google Scholar 

  • Darrow, W.W., Echenberg, D.F., Jaffe, H.W., O’Malley, P.M., Byers, R.H., Getchell, J.P., Curran, J.W. (1987). Risk factors for human immunodeficiency virus infection in homosexual men. AJPH 77, 479–83.

    Article  CAS  Google Scholar 

  • De Gruttola, V. and Mayer, K.H. (1987). Assessing and modeling heterosexual spread of the human immunodeficiency virus in the United States. Rev Inf Dis 10, 138–50.

    Article  Google Scholar 

  • Des Jarlais, D.C. and Friedman, S.R. (Ed. review). (1987). HIV infection among I.V. drug users: epidemiology and risk reduction. AIDS 1, 67–76.

    Google Scholar 

  • Des Jarlais, D.C., Friedman, S.R., Marmor, M., et al. (1987). Development of AIDS, HIV seroconversion, and potential cofactors for T4 cell loss in a cohort of I.V. drug users. AIDS 1, 105–111.

    PubMed  Google Scholar 

  • Des Jarlais, D.C., Friedman, S.R., Novick, D.M., et al. (1989). HIV-1 infection among intravenous drug users entering treatment in Manhatten, New York City, 1978–1987. JAMA 261, 1008–1012.

    Article  PubMed  Google Scholar 

  • Des Jarlais, D.C., Friedman, S.R., and Stoneburner, R.L. (1988). HIV infection and intravenous drug use: critical issues in transmission dynamics, infection outcomes, and prevention. Reviews of Infectious Diseases 10, 151–158.

    Google Scholar 

  • Dietz, K. and Schenzle, D. (1985). Mathematical models for infectious disease statistics. In A Celebration of Statistics, A. C. Atkinson and S. E. Fienberg (eds.). New York, Springer-Verlag, pp. 167–204.

    Chapter  Google Scholar 

  • Dolan, M. P., Black, J. L., Deford, H. A., et al. (1987). Characteristics of drug abusers that discriminate needle-sharers, Public Health Reports, July-August, 395–398.

    Google Scholar 

  • Drucker, E. (1986). AIDS and addiction in New York City. Amer. J. Drug Alcohol Abuse 12, 165–181.

    Article  CAS  Google Scholar 

  • Drucker, E. and Vermund, S.E. (1989). Estimating population prevalence of human immunodeficiency virus infection in urban areas with high rates of intravenous drug use: A model of the Bronx in 1988. Am J Epi 130, 133–142.

    CAS  Google Scholar 

  • Friedland, G.H. and Klein, R.S. (1987). Transmission of the human immunodeficiency virus, New Eng J Med 317, 1125–1135.

    Article  PubMed  CAS  Google Scholar 

  • Goedert, J.J., Eyster, M.E., Biggar, R.J., Blattner, W.A. (1987). Heterosexual transmission of human immunodeficiency virus: association with severe depletion of T-helper lymphocytes in men with hemophilia. AIDS Res Human Retrov 3, 355–61.

    Article  CAS  Google Scholar 

  • Goedert, J.J., Kessler, C.M., Aledort, L.M. et al. (1989). A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with hemophilia. New England J Med 321, 1141–48.

    Article  CAS  Google Scholar 

  • Hessol, N.A., O’Malley, P., Lifson, A., et al. (1989). Incidence and prevalence of HIV infection among homosexual and bisexual men, 1978–1988. Abstract M.A.O. 27, V International Conference on AIDS. Montreal, Canada.

    Google Scholar 

  • Hethcote, H.W. (1987). AIDS modeling work in the United States. In: Future Trends in AIDS, London: Her Majesty’s Stationary Office, pp. 35–46.

    Google Scholar 

  • Hethcote, H.W. and Van Ark, J.W. (1987). Epidemiological models for heterogeneous populations: proportionate mixing, parameter estimation, and immunization programs. Math Biosci 84, 85–118.

    Article  Google Scholar 

  • Hethcote, H. W. and Van Ark, J. W. (1991). Modeling HIV Transmission and AIDS in the United States,(in preparation).

    Google Scholar 

  • Hethcote, H.W., Van Ark, J.W., and Karon, J.M. (1991). A simulation model of AIDS in San Francisco: II. simulations, therapy, and sensitivity analysis. Math Biosci 106, 223–247.

    Article  PubMed  CAS  Google Scholar 

  • Hethcote, H.W., Van Ark, J.W., and Longini, I.M., Jr. (1991). A simulation model of AIDS in San Francisco: I. Model formulation and parameter estimation. Math Biosci 106, 203–222.

    Article  PubMed  CAS  Google Scholar 

  • Hethcote, H.W. and Yorke, J.A. (1984). Gonorrhea Transmission Dynamics and Control. Lecture Notes in Biomathematics 56, Heidelberg, Springer- Verlag.

    Google Scholar 

  • Hethcote, H.W., Yorke, J.A., Nold A. (1982). Gonorrhea modeling: a comparison of control methods. Math Biosci 58, 93–109.

    Article  Google Scholar 

  • Hyman, J.M. and Stanley, E.A. (1988). Using mathematical models to understand the AIDS epidemic. Math Biosci 90, 415–73.

    Article  Google Scholar 

  • Jacquez, J.A., Simon, C.P., Koopman, J., Sattenspiel, L., Perry, T. (1988). Modeling and the analysis of HIV transmission: the effect of contact patterns. Math Biosci 92, 119–99.

    Article  Google Scholar 

  • Kaplan, E.H. and Lee, Y.S. (1990). How bad can it get? Bounding worst case epidemic heterogeneous mixing models of HIV/AIDS. Math Biosci 99, 157–180.

    Article  PubMed  CAS  Google Scholar 

  • Kozel, N.J. and Adams, E.H. (1986). Epidemiology of drug abuse: an overview. Science 34, 970–974.

    Article  Google Scholar 

  • Lambert, B. (1988). Halving of estimate on AIDS is raising doubts in New York. New York Times (July 20 ), 1–28.

    Google Scholar 

  • Lemp, G.F., Payne, S.F., Rutherford, G.W. et al. (1990). Projections of AIDS morbidity and mortality in San Francisco. JAMA 263, 14971501.

    Google Scholar 

  • Lifson, A.R., Hessol, N.A., Rutherford, G..W et al. (1990). The natural history of HIV infection in a cohort of homosexual and bisexual men: clinical and immunological outcomes, 1977–1990. Abstract Th.C. 33, VI International Conference on AIDS, San Francisco, Calif.

    Google Scholar 

  • Longini, I.M., Clark, W.S., Byers, R.H., et al. (1989). Statistical analysis of the stages of HIV infections using a Markov model. Stat in Med 8, 831–43.

    Article  Google Scholar 

  • Longini, I.M., Clark, W.S., Gardner, L.I., Brundage, J.F. (1991). The dynamics of CD4+ T-lymphocyte decline in HIV-infected individuals: A Markov modeling approach. J AIDS,in press.

    Google Scholar 

  • Longini, I.M., Clark, W.S., Ilaber, M., et al. (1990). The stages of HIV infection: Waiting times and infection transmission probabilities. In Castillo-Chavez C, ed., Mathematical and Statistical Approaches to AIDS epidemiology. Lecture Notes in Biomathematics 83, New York, Springer- Verlag, pp. 111–137.

    Google Scholar 

  • Machado, S.G., Gail, M.H., Ellenberg, S.S. (1990). On the use of laboratory markers as surrogates for clinical endpoints in the evaluation of treatment for HIV infection. J AIDS 3, 1065–1073.

    CAS  Google Scholar 

  • May, R.M. (1988). HIV infection in heterosexuals. Nature 331, 655–56. Mulleady, G. and Green, J. (1985). Syringe sharing among London drug abusers. Lancet 8469, 1425.

    Google Scholar 

  • New York City Department of health. (1989). Report of the expert panel on HIV seroprevalence estimates and AIDS case projection methodologies, 1–33.

    Google Scholar 

  • Nold, A. (1980). Heterogeneity in disease transmission modeling. Math Biosci 52, 227–40.

    Article  Google Scholar 

  • Osmund, D., Bacchetti, P., Chaisson, R.E., Kelly, T., Stempel, R., Carlson, J., Moss, A.R. (1988). Time of exposure and risk of HIV infection in homosexual partners of men with AIDS. AJPH 78, 944–48.

    Article  Google Scholar 

  • Payne, S.F., Lemp, G.F., Rutherford, G.W., et al. (1989). Effect of multiple disease manifestations on length of survival for AIDS patients in San Francisco, Abstract W.A.P.80, V International Conference on AIDS, Montreal, Canada, June 1989.

    Google Scholar 

  • Padian, N.S. (1987). Heterosexual transmission of AIDS: International perspectives and national projections. Rev Inf Dis 9, 947–960.

    Article  CAS  Google Scholar 

  • Pagano, M., DeGruttola, V., MaWhinney, S., Tu, X.M. (1991). The HIV epidemic in New York City: Statistical methods for projecting AIDS incidence and prevalence. In AIDS Epidemiology: Methodological Issues, N. Jewell, K. Dietz and V. Farewell (eds.), Boston: BirkhäuserBoston.

    Google Scholar 

  • Pickering, J. Wiley, J.A., Padian, N.S., Lieb, L.E., Echenberg, D.F., Walker, J. (1986). Modeling the incidence of A.I.D.S. in San Francisco, Los Angeles, and New York. Math Modeling 7 661–88.

    Google Scholar 

  • Redfield, R.R., Wright, D.C., Tramont, E.C. (1986). The Walter Reed staging classification for HTLV-III/LAV infection. N Eng J Med 314, 131–2.

    Article  CAS  Google Scholar 

  • Schuster, C.R. (1988). Intravenous drug use and AIDS prevention, Public Health Reports 103, 1125–1135.

    Google Scholar 

  • Seligmann, M., Pinching, A.J., Rosen, F.S. et al. (1987). Immunology of human immunodeficiency virus and the acquired immune deficiency syndrome. Ann Int Med 107, 234–42.

    PubMed  CAS  Google Scholar 

  • Selwyn, P.A., Feiner, C., Cox, C.P., et al. (1987). Knowledge about AIDS and high-risk behavior among intravenous drug users in New York City. AIDS 1, 247–254.

    PubMed  CAS  Google Scholar 

  • Steinbrook, R. (1988). AIDS slowdown in 3 key cities seen. Los Angeles Times, December 6, pp. 1–26.

    Google Scholar 

  • Stoneburner, R.L., Des Jarlais, D.C., Benezra, D., et al. (1988). A larger spectrum of severe HIV-1-related disease in intravenous drug users in New York City. Science 242, 916–919.

    Article  PubMed  CAS  Google Scholar 

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Hethcote, H.W., Van Ark, J.W. (1992). Weak Linkage Between HIV Epidemics in Homosexual Men and Intravenous Drug Users. In: Jewell, N.P., Dietz, K., Farewell, V.T. (eds) AIDS Epidemiology. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4757-1229-2_9

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  • DOI: https://doi.org/10.1007/978-1-4757-1229-2_9

  • Publisher Name: Birkhäuser, Boston, MA

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