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Control of the Coronary Circulation

  • Chapter
Physiology and Pathophysiology of the Heart

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 34))

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Abstract

Normal function of the heart depends on an adequate coronary blood flow. Myocardial metabolism and coronary flow are mutually interactive so that any increase in the metabolism of the normal heart is matched by an increase in coronary blood flow, and any significant restriction of flow in pathophysiologic states results in the reduction of myocardial metabolism and cardiac performance. In this chapter we describe the determinants of coronary blood flow; these include physical factors, myocardial metabolism, humoral influences, and neural control. In addition, we discuss certain pathophysiologic conditions, such as vascular responses to cardiac hypertrophy and myocardial ischemia, and the significance of coronary collateral vessels.

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Authors
  1. Harvey V. Sparks Jr.
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  2. Roger D. Wangler
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  3. Donald F. Dewitt
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  1. Department of Physiology, University of Cincinnati Medical Center, 231 Bethesda Avenue, 45267, Cincinnati, Ohio, USA

    Nicholas Sperelakis

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Sparks, H.V., Wangler, R.D., Dewitt, D.F. (1984). Control of the Coronary Circulation. In: Sperelakis, N. (eds) Physiology and Pathophysiology of the Heart. Developments in Cardiovascular Medicine, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1171-4_39

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