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Effects of and the Mechanism of Action of Calcium Antagonists and other Antianginal Agents

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Physiology and Pathophysiology of the Heart

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 34))

Abstract

It is one of the most important achievements in modern basic cardiology that many substances with a positive or negative inotropic effect on heart muscle act as promoters or inhibitors of the mediator function of Ca2+-ions in excitation—contraction coupling. For instance, ß-adrenergic stimulation with adrenaline, nor-adrenaline, or isoproterenol facilitates the transmembrane Ca2+ influx during excitation. Splitting of ATP by the Ca2+-activated myofibrillar ATPase, and contractile tension development, are thereby augmented. Similarly, under the influence of cardiac glycosides, more Ca2+ is made available to the contractile myofibrils. Conversely, a number of negative isotropic substances can inhibit excitation—contraction coupling of heart muscle by a Ca2+- antagonistic effect.

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  1. A. Fleckenstein
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  2. G. Fleckenstein-Grün
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Editors and Affiliations

  1. Department of Physiology, University of Cincinnati Medical Center, 231 Bethesda Avenue, 45267, Cincinnati, Ohio, USA

    Nicholas Sperelakis

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Fleckenstein, A., Fleckenstein-Grün, G. (1984). Effects of and the Mechanism of Action of Calcium Antagonists and other Antianginal Agents. In: Sperelakis, N. (eds) Physiology and Pathophysiology of the Heart. Developments in Cardiovascular Medicine, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1171-4_19

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  • DOI: https://doi.org/10.1007/978-1-4757-1171-4_19

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