Abstract
PUVA (psoralen and near ultraviolet light) is a DNA-damaging, clinically effective treatment. If we have patience, studies of PUVA therapy should give us a rare opportunity to learn much about not only the diseases it treats, but also about diseases it may cause. PUVA is a gamble, a calculated risk.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Al-Saleem, R., Ali, Z.S., and Qassah, M., 1980, Skin cancers in xeroderma pigmentosum: response to indomethacin and steroids. Lancet, ii: 264.
Arlett, C.F., Heddle, J.A., Broughton, B.C., and Rogers, A.M., 1980, Cell killing and mutagenesis by 8-methoxypsoralen in mammalian (rodent) cells. Clin. Exp. Dermatol., 5: 147.
Ashwood-Smith, M.J., Grant, E.L., Heddle, J.A., and Friedman, G.B., 1977, Chromosome damage in Chinese hamster cells sensitized to near-ultraviolet light by psoralen and angelicin, Mutation Res., 43: 377.
Baltimore, D., 1974, Is terminal deoxynucleotidyl transferase a somatic mutagen for lymphocytes?, Nature, 248: 409.
Bridges, B.A., 1978, Possible long-term hazards of photochemotherapy with psoralens and near-ultraviolet light, Clin. Exp. Dermatol., 3: 349.
Bridges, B.A., 1979, An estimate of genetic risk from 8-methoxypsoralen photochemotherapy, Hum. Genet., 49: 91.
Bridges, B.A. and Strauss, G.H., 1980, Possible hazards of photochemotherapy for psoriasis, Nature, 218: 523.
Bridges, B.A., Greaves, M., Polani, P.E., and Wald, N., in press, Do treatments available for psoriasis patients carry a genetic or carcinogenic risk? A report from an expert group of the International Commission for Protection against Environmental Mutagens and Carcinogens, Mutation Res. and Biol. Zentr.
Bridges, B.A., Strauss, G.H., Hall-Smith, P., and Price, M., 1981, Induction of somatic mutations and impairment of immune capacity by PUVA treatment and their relation to skin cancer in man, in: “Psoralens in Cosmetics and Dermatology”, Pergamon Press, Paris.
Catalona, W.J., Taylor, P.T. and Chretieu, P.B., 1972, Quantitative dinitrochlorobenzene contact sensitization in a normal population, Clin. Exp. Immunol., 12: 325.
Cormane, R.H., Hamerlinck, F. and Siddiqui, A.H., 1979, Immunologic implications of PUVA therapy in psoriasis vulgaris, Arch. Dermatol. Res., 265: 275.
Evans, D.L., and Morrow, R.J., 1979, 8-methoxypsoralen induced alterations of mammalian cells, J. Invest. Dermatol., 72: 35.
Griffin, A.C., 1959, Methoxsalen in ultraviolet carcinogenesis in the mouse. J. Invest. Dermatol. 31: 367.
Igali, S., Bridges, B.A., Ashwood-Smith, M.J., and Scott, B.R., 1970, Mutagenesis in Escherichia coli IV, Photosensitization to near-ultraviolet light by 8-methoxypsoralen, Mutation Res., 9: 21.
Kerkis, J.J., and Skorova, S.V., 1973, Humoral factors of “spontaneous” mutagenesis in mammals and man. Mutation Res., 18: 179.
Kinlin, L., et al., 1979, Collaborative United Kingdom/Australian study of cancer patients treated with immunosuppressive drugs, Brit. Med. J., 2: 1461.
Kraemer, R.H. and Weinstein, G.D., 1977, Decreased thymidine incorporation in circulating leukocytes after treatment of psoriasis with psoralen and long-wave ultraviolet light, J. Invest. Dermatol., 69: 211.
Malling, H.V., 1976, Mutagenesis testing: mammalian systems. Mutation Res., 41: 171.
Melski, J.W., Tanenbaum, L., Parrish, J.A., et al., 1977, Oral methoxsalen photochemotherapy for the treatment of psoriasis: a co-operative clinical trial, J. Invest. Dermatol., 68: 328.
Morhenn, V.B., Benike, B.S., and Engleman, E.G., 1980, Inhibition of cell mediated immune response by 8-methoxypsoralen and long-wave ultraviolet light: a possible explanation for the clinical effects of photo-activated psoralens, J. Invest. Dermatol., 75: 249.
Morison, W.L., Woehler, M.E., and Parrish, J.A., 1979, PUVA and systemic immunosuppression in guinea pigs. J. Invest. Dermatol., 72: 273.
Morison, W.L., Parrish, J.A., McAuliffe, D.J. and Bloch, K.J., 1981, Sensitivity of mononuclear cells to PUVA: effect on subsequent stimulation with mitogens and on exclusion of trypan blue dye, Clin. Exp. Dermatol., 6: 273.
Parrish, J.A., Fitzpartick, T.B., Tanenbaum, L., and Pathak, M.A., 1974, Photochemotherapy for psoriasis with oral methoxsalen and longwave ultraviolet light, New Engl. J. Med., 291: 1207.
Parrish, J.A., LeVine, M.J., and Fitzpatrick, T.B., 1980, Oral methoxsalen photochemotherapy of psoriasis and mycosis fungoides, Int. J. Dermatol., 19: 379.
Reed, W.D., 1976, Treatment of psoriasis with oral psoralens and longwave ultraviolet light, Acta Dermato-vener., 56: 315.
Roberts, L.K., Schmitt, M., and Daynes, R.A., 1979, Tumour susceptibility generated in mice treated with subcarcinogenic doses of 9-methoxypsoralen and longwave ultraviolet light, J. Invest. Dermatol., 72: 306.
Stern, R.S., Thibodeau, L.A., Kleinerman, R.A., Parrish, J.A., Fitzpatrick, et al., 1979, Risk of cutaneous carcinoma in patients treated with oral methoxsalen photochemotherapy for psoriasis, New. Engl. J. Med., 300–309.
Strauss, G.H., in press, PUVA-Gambling with a system? Int. J. Dermatol.
Strauss, G.H., and Albertini, R.J., 1979, Enumeration of 6-thioguanine peripheral blood lymphocytes as a potential test for somatic cell mutations arising in vivo, Mutation Res., 61: 353.
Strauss, G.H., Albertini, R.J., Krusinki, P.A., and Baughman, R.D., 1979, 6-thioguanine-resistant peripheral blood lymphocytes in humans following psoralen longwave UV light therapy, J. Invest. Dermatol., 73: 211.
Strauss, G.H., Bridges, B.A., Greaves, M., Hall-Smith, P., Price, M., and Vella-Briffa, D. 1980, Inhibition of delayed hypersensitivity reaction in skin (DNCB test) by 8-methoxypsoralen photochemotherapy: possible basis for pseudo-promoting action in skin carcinogenesis? Lancet, 2: 556.
Svejgaard, A., Nielsen, L., Svejgaard, E., Kissmeyer-Nielsen, F., Hjortshcj, A., and Zachariae, H., 1974, HL-A in psoriasis vulgaris and in pustular psoriasis-population and family studies, Brit. J. Dermatol., 91: 145.
Toews, G., Borgstresser, P.R., and Streilein, J.W., 1980, Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB, J. Immunol., 124: 445.
Updike, J., 1979, From the journal of a leper, in: “Problems and Other Stories”, Knopf, New York.
Vella-Briffa, D., and Warin, A.P., 1979, Photochemotherapy in psoriasis: A review, J. R. Soc. Med., 72: 440.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer Science+Business Media New York
About this chapter
Cite this chapter
Strauss, G.H.S. (1983). PUVA Therapy: Immunologic and Genotoxic Approaches to Risk Evaluation. In: Castellani, A. (eds) The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1117-2_17
Download citation
DOI: https://doi.org/10.1007/978-1-4757-1117-2_17
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-1119-6
Online ISBN: 978-1-4757-1117-2
eBook Packages: Springer Book Archive