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Assessment of Human Lymphoid Cell Damage Induced by Therapeutic Levels of 8-Methoxypsoralen and Long Wavelength Ultraviolet Radiation In Vitro

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The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents

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Abstract

An earlier presentation to this conference dealt with general properties of human lymphoblastoic cell lines and their possible role in risk assessment. This paper will present a specific example of the use of lymphoblastoid cell lines to evaluate risk in patients receiving oral 8-methoxypsoralen (8-MOP) plus longwave ultraviolet radiation (UV-A) photochemotherapy. This experimental therapy has been given the acronym “PUVA.”

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Authors and Affiliations

  1. Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland, 20205, USA

    Kenneth H. Kraemer

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  1. Kenneth H. Kraemer
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Editors and Affiliations

  1. Casaccia Center for Nuclear Studies, Rome, Italy

    Amleto Castellani

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Kraemer, K.H. (1983). Assessment of Human Lymphoid Cell Damage Induced by Therapeutic Levels of 8-Methoxypsoralen and Long Wavelength Ultraviolet Radiation In Vitro . In: Castellani, A. (eds) The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1117-2_11

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  • DOI: https://doi.org/10.1007/978-1-4757-1117-2_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1119-6

  • Online ISBN: 978-1-4757-1117-2

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