Abstract
The kindling model of epilepsy offers the possibility of studying a number of general properties of the central nervous system: namely, (1) how plasticity or malleability in neuronal networks can be expressed and (2) how the system may become instable such that the ongoing activity is disrupted. The first point pertains to the question of synaptic plasticity, and the second point is related to the question of the maintenance or interruption of the flow of consciousness.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Babloyantz, A., Salazar, J.M., Nicolis., C (1985): Evidence of chaotic dynamics of brain activity during the sleep cycle. Physics Lett. 111A, 152–156
Babloyantz, A., Destexhe A. (1986): Low-dimensional chaos in an instance of epilepsy. Proc. Natl. Acad. Sci. USA 83, 3513–3517
Basar, E., ed. (1988) Dynamics of sensory and cognitive processing by the brain. Berlin: Springer
Brazier, M.A.B. (1972): Spread of seizure discharges in epilepsy: Anatomical and electrophysiological considerations. Exp. Neurol. 36, 263–272
Brazier, M.A.B. (1973): Electrical seizure discharges within the human brain: The problem of spread. In: Epilepsy: Its phenomena in man. Brazier, M.A.B. (ed.). New York: Academic Press, pp. 153–170
Buzsaki, G., Eidelberg, E. (1982): Direct afferent excitation and long-term potentiation of hippocampal interneurons. J. Neurophysiol. 48, 597–607
Celio, M.R. (1986): Parvalbumin in most gamma-aminobutyric acid containing neurons of the rat cerebral cortex. Science N.Y. 231, 995–997
Collingridge, G.L., Kehl, S.J., McLennan, H. (1983): The antagonism of aminoacidinduced excitation of the hippocampal CAl neurons in vitro. J. Physiol. 334, 19–32
Dvorak, I., Siska, J. (1986): On some problems encountered in the estimation of the correlation dimension of the EEG. Physics Lett. A. 118, 63–66
Fernandes de Lima, Pijn, J.P., Nunes, F.C., Lopes da Silva, F.H. (1990): The role of hippocampal commissures in the interhemispheric transfer of epileptiform afterdischarges in the rat: a study using linear and nonlinear regression analysis. Electroenceph. Clin. Neurophysiol (In Press)
Freeman, W. (1988): Nonlinear neural dynamics in olfaction as a model for cognition. In: Dynamics of sensory and cognitive processing by the brain. Basar, E. (ed.). Berlin: Springer, pp. 19–29
Goddard, G.V., McIntyre, P.C., Leech, D.K. (1969): A permanent change in brain function resulting from daily electrical stimulation. Exp. Neurol 25, 295–330
Gotman, J. (1983): Measurement of small time differences between EEG channels: Method and application to epileptic seizure propagation. Electroenceph. Clin. Neurophysiol 56, 501–514
Gotman, J. (1987): Interhemispheric interactions in seizures of focal onset: Data from human intracranial recordings. Electroenceph. Clin. Neurophysiol. 67, 120–133
Grassberger, P., Procaccia, I. (1983): Measuring the strangeness of strange attractors. Physics 9D, 189–208
Guilford, J.P., Fruchter, B. (1985): Fundamental statistics in psychology and education. New York: McGraw Hill
Hamon, B., Heinemann, U. (1986): Effects of GABA and bicuculline on NMDA- and quisqualate-induced reductions in extracellular free calcium in area CAl of the hippocampal slice. Exp. Brain Res. 64, 27–36
Harris, E.W., Ganong, A.H., Cotman, C.W. (1984): Long-term potentiation in the hippo-campus involves activation of N-methyl-D-aspartate receptors. Brain Res. 323, 132–137
Kamphuis, W., Wadman, W.J., Buijs, R.M., Lopes da Silva, F.H. (1987): The development of changes in hippocampal GABA immunreactivity in the rat kindling model of epilepsy: A light microscopic study with GABA antibodies. Neuroscience 23, 433–446
Kamphuis, W., Lopes da Silva, F.H., Wadman, W.J. (1988): Changes in local evoked potentials in the rat hippocampus (CA1) during kindling epileptogenesis. Brain Res. 440, 205–215
Kamphuis, W., Huisman, E., Wadman, W.J., Heizmann, C.W., Lopes da Silva, F.H. (1989a): Kindling-induced changes in parvalbumin immunoreactivity in rat hippocampus and its relation to long-term decrease in GABA-immunoreactivity. Brain Res. 479, 23–34
Kamphuis, W., Wadman, W.J., Huisman, E., Lopes da Silva, F.H. (1989b): Decrease in GABA immunoreactivity and alteration of GABA metabolism after kindling in the rat hippocampus. Exp. Brain Res. 74, 375–386
Kamphuis, W., Wadman, W.J., Huisman, E., Lopes da Silva, F.H. (1989 c): Transient increase of cytoplasmic calcium concentration in the rat hippocampus after kindling-induced seizures. An ultrastructural study with the oxalate-pyro-antimonate technique. Neuroscience 29, 667–674
Kamphuis, W., Huisman, E., Dreijer, A.M.C., Ghijsen, W.E.J.M., Verhage, M., Lopes da Silva, F.H. (1990): Kindling increase the Kevoked Ca-dependent release of endogenous GABA in the area CAI of rat hippocampus. Brain Res. 511, 63–70
King, G.I., Dingledine, R., Giachino, J.L., McNamara, J.O. (1985): Abnormal neuronal excitability in hippocampal slices from kindled rats. J. Neurophyyiol. 54, 1295–1304
Knowles, D.W., Schneiderman, J.H., Wheal, H.V., Stafsrom, C.E., Schwartzkroin, P.A. (1984): Hyperpolarizing potentials in guinea pig hippocampal CA3 neurons. Cell Mol. Neurobiol. 4, 207–230
Kosaka, T., Katsumar, H., Hama, K., Wu, J-Y, Heizmann, C.W. (1987): GABAergic neurons containing the Cat+ binding protein parvalbumin in the rat hippocampus and the dentate gyrus. Brain Res. 419, 119–130
Leung, L.S. (1979): Orthodromic activation of the hippocampal CAl region in the rat. Brain Res. 176, 49–63
Leung, L.S. (1982): Nonlinear feedback model of neuronal populations in hippocampal CA1 region. J. Neurophysiol. 47, 845–868
Lopes da Silva, F.H., Arnolds, D.E.A.T. (1978): The physiology of the hippocampus and related structures. Annu. Rev. Physiol. 40, 163–191
Lopes da Silva, F.H., Mars, N.J.I. (1987): Spread of epileptic seizure activity in experimental and clinical epilepsy: The use of mutual information analysis. In: Presurgical evaluation of epileptics. Wieser, H.G., Eiger, C.E. (eds.). Berlin: Springer, pp. 209–214
Mars, N.J.I., Van Arragon, G.W. (1982): Time delay estimation in non-linear systems using average amount of mutual information analysis. Signal Processing 4, 139–153
Mars, N.J.I., Lopes da Silva, F.H. (1987): EEG analysis methods based on information theory. In: Methods of analysis of brain electrical and magnetic signals. Gevins, A.S., Rémond, A. (eds.) Amsterdam: Elsevier, pp. 297–307
Mars, N.J.I., Lopes da Silva, F.H, Van Hutten, K., Lommen, J.G. (1977): EEGs during seizures; Localisation of an epileptogenic area. Electroenceph. Clin. Neurophysiol. 43, 575
Melchers, B.P.C., Pennartz, C.M.A., Wadman, W.J., Lopes da Silva, F.H. (1988): Quantitative correlation between induced decreases in extracellular calcium and LTP. Brain Res. 454, 1–10
Moddemeijer, R. (1987): Estimation of entropy and mutual information of continuous distribution. Internal Report, University of Twente, (The Netherlands), Nr. 080–87–33
Moddemeijer, R. (1989): Delay-estimation with application to electroencephalograms in epilepsy. Ph.D. thesis. University of Twente, Enschede (The Netherlands )
Mody, I., Heinemann, U. (1987): N-methyl-D-aspartate (NMDA) receptors of dentate gyms granule cells participate in synaptic transmission following kindling. Nature 326, 701–703
Morrell, F., Rasmussen, T., Gloor, P., De Toledo-Morrell, L. (1983): Secondary epileptogenic foci in patients with verified temporal lobe tumors. Electroenceph. Clin. Neurophysiol. 54, 26 P
McNamara, J.O. (1986): Kindling model of epilepsy. In: Advances in neurology: vol 44. Delgado-Escueta, A.V., Ward Jr. A.A., Woodbury, D.M., Porter, R.J. (eds.). New York: Raven Press, pp. 1033–1044
Pjin, J.P.M., Vign, P.C.M., Lopes da Silva, F.H. (1989): Localization of epileptogenic foci using a new signal analytical approach. Neurophysiol. Clin. 20, 1–11
Racine, R.J. (1972): Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroenceph. Clin. Neurophysiol. 32, 295–299
Röschke, J., Basar, E. (1988): The EEG is not a simple noise: Strange attractors intracranial structures. In: Dynamics of sensory and cognitive processing by the brain. Basar, E. (ed.). Berlin: Springer
Rosén, I., Salford, L., Starck, L. (1984): Sturge-Weber disease—neurophysical evaluation of a case with secondary epileptogenesis, successfully treated with lobectomy. Neuropediatrics 15, 95–98
Schramka, M., Sedlak, P., Nadvomik, P. (1977): Observation of kindling phenomenon in treatment of pain by stimulation in thalamus. In: Neurosurgical treatment in psychiatry, pain and epilepsy. Sweet, W.H., Obrador, S., Matin-Rodriguez, J.G. (eds.). Baltimore: University Park Press, pp. 651–654
Schuster, H.G. (1984): Deterministic chaos. Weinheim West Germany: Physik-Verlag Serra, R., Andretta, M., Zanarimi, G., Compiani, M. (1986): Introduction to the physics of complex septens. Oxford: Pergamon Press
Servit, Z., Musil, F. (1981): Prophylactic treatment of posttraumatic epilepsy: Results of long-term follow-up in Czechoslovakia. Epilepsia 22, 315–320
Stelzer, A., Slater, N.T., Ten Bruggencate, G. (1987): Activation of NMDA receptors blocks GABAergic inhibition in an in vitro model of epilepsy. Nature 326, 698–701
Stichell, C.C., Singer, W., Heizmann, C.W. (1988): Light and electron microscopic immunocytochemical localization of parvalbumin in the dorsal lateral geniculate nucleus of the cat: Evidence for coexistence with GABA. J. Comp. Neurol. 268, 29–37
Schwartzkroin, A. (1986): A regulation of excitability in hippocampal neurons. In: The hippocampus: vol. 3. Isaacson, R.L., Pibram, K.H. (eds.). New York: Raven Press, pp. 113–136
Takens, F. (1981): Dynamical systems and turbulence. In: Lecture notes in mathematics vol. 898, Rand, D.A., Young, L.S. (eds.). Berlin: Springer, pp. 365–381
Theiler, J. (1986): Spurious dimension from correlation algorithms applied to limited time-series data. Physiol Rev A, 34, 3427–3432
Traub, R.D., Wong, R.K.S. (1983): Synchronized burst discharge in disinherited hippo-campai slice. II. Model of cellular mechanism. J. Neurophysiol. 49, 442–558
Van Neerven, J.M.A.M. (1987): Determination of the correlation dimension from a time series: Applications to rat EEGs in sleep, theta rhythm and epilepsy. Master’s thesis, University of Amsterdam, Amsterdam
Wada, J.A., Sato, M, Corcoran, M.E. (1974): Persistent seizure susceptibility and recurrent spontaneous seizures in kindled cats. Epilepsia 15, 464–478
Wadman, W.J., Lopes da Silva, F.H., Leung, L.S. (1983): Two types of interictal transients of reversed polarity in rat hippocampus during kindling. Electroenceph. Clin. Neurophysiol. 55, 314–319
Wadman, W.J., Heinemann, U., Konnerth, A., Neuhaus, S. (1985): Hippocampal slices of kindled rats reveal calcium involvement in epileptogenesis. Exp. Brain Res. 57, 404–407
Xu, N., Xu, J., (1988): The fractal dimension of EEG as a physical measure of conscious human brain activities. Bull. Math Biol. 50, 559–565
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer Science+Business Media New York
About this chapter
Cite this chapter
Da Silva, F.H.L., Kamphuis, W., Van Neerven, J.M.A.M., Pijn, J.P.M. (1990). Cellular and Network Mechanisms in the Kindling Model of Epilepsy: The Role of GABAergic Inhibition and the Emergence of Strange Attractors. In: John, E.R., Harmony, T., Prichep, L.S., Valdés-Sosa, M., Valdés-Sosa, P.A. (eds) Machinery of the Mind. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4757-1083-0_6
Download citation
DOI: https://doi.org/10.1007/978-1-4757-1083-0_6
Publisher Name: Birkhäuser, Boston, MA
Print ISBN: 978-1-4757-1085-4
Online ISBN: 978-1-4757-1083-0
eBook Packages: Springer Book Archive