Skip to main content
SpringerLink
Log in

Localization of Glandular Kallikreins and Secretion of Kallikrein from the Major Salivary Glands of the Rat

  • Chapter
  • First Online:
Kinins—II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 120))

Abstract

Glandular kallikreins (E.C.3.4.21.8) are found in major exocrine glands as well as in the kidney. These kinin-forming enzymes are also present in the glandular secretions and preurine, and, they are believed to be synthesized in the respective organs (Nustad et al., 1975). The physiological function of kallikrein in exocrine glands and the kidney is incompletely understood. However, the cellular localization and secretory pattern of kallikrein may give some indication as to the physiological role of kininogenases in these organs. Moreover, such information is also important for designing experiments to study the physiological function of glandular kallikreins. The cellular localization of kallikrein was therefore investigated by means of a direct immunofluarescence technique in the major salivary glands, the pancreas, the kidney, and the exorbital lacrimal gland of the rat. The secreti kallikrein into saliva from the major salivary glands was investigated after various types of gland activation. Some of these results have been published previously (Ørstavik et al., 1975; Ørstavik et al., 1976; Ørstavik and Gautvik, 1977; Ørstavik and Gleaner, 1978).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Albano, J., K.D. Bhoola, P.F. Heap, and M.J.C. Lemon, 1976. Stimulus-secretion coupling: role of cyclic AMP, cyclic GM2 and calcium in mediating enzyme (kallikrein) secretion in the submandibular gland. J. Physiol. 258: 631.

    Article  CAS  Google Scholar 

  • Barton, S., E.J. Sanders, M. Schachter and M. Uddin, 1975. Autonomic nerve stimulation, kallikrein content and acinar cell granules of the cat’s submandibular gland. J. Physiol. 251: 363.

    Article  CAS  Google Scholar 

  • Bhoola, K.D., M.J.C. Lemon, and R.W. Matthews, 1977. Immunofluorescent localization of kallikrein in the guinea-pig submandibular gland. J. Physiol. (Land.) 272: 28 P.

    Google Scholar 

  • Brandtzaeg, P. 1973. Conjugates of immunoglobulin G with different fluorochromes. I. Characterization by anionic-exchange chromatography. Scand. J. Immunol. 2: 273.

    CAS  PubMed  Google Scholar 

  • Brandtzaeg, P., K.M. Gautvik, K. Nustad, and J.V. Pierce, 1976. Rat submandibular gland kallikreins: purification and cellular localization. Br. J. Pharmacol. 56: 155.

    Article  CAS  Google Scholar 

  • Chao, J. and H.S. Margolius, 1978. Identification of kallikrein in toad urinary bladder and skin and its inhibition by amiloride. Clin. Res. 26: 63A.

    Google Scholar 

  • Chauncey, H.H. and G. Quintarelli, 1961. Localication of acid phosphatase, nonspecific esterases and 3-D-galactosidase in parotid and submaxillary glands of domestic and laboratory animals. Am. J. Anat. 108: 263.

    Article  CAS  Google Scholar 

  • Ekfors, T.O. and V.K. Hopsu-Havu, 1971. Immunofluorescent localization of trypsin-like esteropeptidases in the mouse sub-mandibular gland. Histochem. J. 3: 415.

    Article  CAS  Google Scholar 

  • Ekholm, R., T. Zelander, and Y. Edlund, 1962. The ultrastructural organization of the rat exocrine pancreas. II. Centroacinar cells, intercalary and intralobular ducts. J. Ultrastruct. Res, 7: 73.

    Article  Google Scholar 

  • Fräki J.E., C.T. Jansén, and V.K. Hopsu-Havu, 1970. Human sweat kallikrein. Acta Dermat. (Stockholm) 50: 321

    Google Scholar 

  • Frey, E.K., H. Kraut, E. Werle, R. Vogel, G. Zickgraf-Fudel and I. Trautschold, 1968. Das Kallikrein-Kinin-System und seine lnhibitoren. Ferdinand Enke Verlag, Stuttgart.

    Google Scholar 

  • Gautvik, K.M., M. Kriz, K. Lund-Larsen, and K. Nustad, 1974. Control of kallikrein secretion from salivary glands. In: Secretory mechanisms of exocrine glands. Eds. N. A. Thorn and 0.H. Petersen. Munksgaard, Copenhagen, pp. 168.

    Google Scholar 

  • Hojima, Y., B. Maranda, C. Moriwaki, and M. Schachter, 1977. Direct evidence for the localization of kallikrein in the striated ducts of the cat’s submandibular gland by the use of specific antibody. J. Physiol. (Lond.) 263: 793.

    Article  Google Scholar 

  • Levi-Mantalcini, R. and P.U. Angeletti, 1961. Growth control of the sympathetic system by a specific protein factor. Quart. Rev. Biol. 36: 99.

    Article  Google Scholar 

  • Nustad, K. and J.V. Pierce, 1974. Purification of rat urinary kallikreins and their specific antibody. Biochem. 13: 2312.

    Article  CAS  Google Scholar 

  • Nustad, K., J.V. Pierce, and K. Vaaje, 1975. Synthesis of kallikrein by rat kidney slices. Br. J. Pharmacol. 53: 229.

    Article  CAS  Google Scholar 

  • Ørstavik, T.B., 1978a. An immunohistochemical study of kallikrein in the rat parotid and exorbital lacrimal glands. Arch. oral Biol. In press.

    Google Scholar 

  • Ørstavik, T.B., 1978b. The distribution and secretion of kallikrein in some exocrine organs of the rat. Acta physiol. Scand. Dec. In press.

    Google Scholar 

  • Ørstavik, T.B., P. Brandtzaeg, K. Nustad, and K.M. Halvorsen, 1975. Cellular localization of kallikrein in the rat submandibular and sublingual salivary glands. Immunofluorescence tracing related to histological characteristics. Acta histochem. 54: 183.

    PubMed  Google Scholar 

  • Ørstavik, T.B. and K.M. Gautvik, 1977. Regulation of salivary kallikrein secretion in the rat submandibular gland. Acta physiol. Scand. 100: 33.

    Google Scholar 

  • Ørstavik, T.B. and G.G. Glenner, 1978. Localization of kallikrein and its relation to other trypsin-like esterases in the rat pancreas. A comparison with the submandibular gland. Acta physiol. Scand. 103: 384.

    Google Scholar 

  • Ørstavik, T.B., K. Nustad, and P. Brandtzaeg, 1977. A biochemical and immunohistochemical study of kallikrein in normal and isoproterenol-stimulated rat salivary glands during postnatal development. Archs. oral. Biol. 22: 495.

    Google Scholar 

  • Ørstavik, T.B., K. Nustad, P. Brandtzaeg, and J.V. Pierce. Cellular origin of urinary kallikreins. J. Histochem. Cytochem. 24: 1037.

    Google Scholar 

  • Proud, D., G. Bailey, K. Nustad, and K.M. Gautvik, 1977. The immunological similarity of rat glandular kallikreins. Biochem. J. 167: 835.

    Article  CAS  Google Scholar 

  • Scicli, A.G., R. Candolfi, and 0.A. Carretero, 1978. Site of formation of kinins in the dog nephron. Am. J. Physiol. 234: F36.

    Article  CAS  Google Scholar 

  • Simson, J.A.V., J. Chao, and H.S. Margolius, 1978. Cytochemical localization and secretagogue-induced release of kallikrein and nerve growth factor from rodent salivary glands. Anat. Rec. 190: 542.

    Google Scholar 

  • Strauss, J.S. and A.G. Matolsky, 1973. Skin. In: Histology 3. ed. Eds. R.O. Creep and L. Weiss. McGraw-Hill Book Company, New York, pp. 477.

    Google Scholar 

  • Uddin, M. and D.W. Tyler, 1978. Localization of kallikrein by a direct method. J. Dent. Res. Spec. Issue A, Abstr. nr. 1183.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Physiol. and Biochem., Dent. Fac., Univ. of Oslo, Oslo, Norway

    Torill B. Ørstavik

  2. Inst. Physiol., Med. Fac., Univ. of Oslo, Oslo, Norway

    K. M. Gautvik

  3. Dept. of Clin. Chem., The Norwegian Radium Hosp., Oslo, Norway

    K. Nustad & K. M. Gautvik

Authors
  1. Torill B. Ørstavik
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Nustad
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. M. Gautvik
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute for Protein Research, Osaka University, Osaka, Japan

    Setsuro Fujii

  2. Science University of Tokyo, Tokyo, Japan

    Hiroshi Moriya

  3. Meiji College of Pharmacy, Tokyo, Japan

    Tomoji Suzuki

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ørstavik, T.B., Nustad, K., Gautvik, K.M. (1979). Localization of Glandular Kallikreins and Secretion of Kallikrein from the Major Salivary Glands of the Rat. In: Fujii, S., Moriya, H., Suzuki, T. (eds) Kinins—II. Advances in Experimental Medicine and Biology, vol 120. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-0926-1_40

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-0926-1_40

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-0928-5

  • Online ISBN: 978-1-4757-0926-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation