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Use of Squirrel Monkeys in Cardiovascular Research

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Handbook of Squirrel Monkey Research

Abstract

Squirrel monkeys (Saimiri sciureus) have been the most widely used of the New World monkeys in cardiovascular research. The majority of the cardiovascular research done with squirrel monkeys has concerned atherosclerosis both as it occurs naturally in these animals and with regard to the effect of diet on the progression of atherosclerotic lesions. Of the several subspecies of squirrel monkeys, Brazilian-type squirrel monkeys have been used almost exclusively in the research on atherosclerosis. To a somewhat lesser extent, squirrel monkeys have been used to study behavioral influences on hypertension, myocardial necrosis, and cholelithiasis as a complication of unsaturated fat diets. In this review, we summarize naturally occurring atherosclerosis, the effects of dietary manipulations on atherosclerosis progression, the effects of physiological and psychological manipulations on diet-induced atherosclerosis, the complications of atherosclerosis, stress-induced myocardial disease, behaviorally induced hypertension, and, finally, some of the diseases that complicate the use of squirrel monkeys in cardiovascular research.

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Author information

Authors and Affiliations

  1. Laboratory of Behavioral Medicine, Southwest Foundation for Biomedical Research, San Antonio, Texas, 78284, USA

    Harriet L. Strickland

  2. Department of Comparative Medicine and Arteriosclerosis Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina, 27103, USA

    Thomas B. Clarkson

Authors
  1. Harriet L. Strickland
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  2. Thomas B. Clarkson
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Editor information

Editors and Affiliations

  1. Primate Behavior Laboratory and Department of Psychiatry, State University of New York Downstate Medical Center, 11203, Brooklyn, New York, USA

    Leonard A. Rosenblum

  2. Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 94305, Stanford, California, USA

    Christopher L. Coe

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© 1985 Springer Science+Business Media New York

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Strickland, H.L., Clarkson, T.B. (1985). Use of Squirrel Monkeys in Cardiovascular Research. In: Rosenblum, L.A., Coe, C.L. (eds) Handbook of Squirrel Monkey Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0812-7_12

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  • DOI: https://doi.org/10.1007/978-1-4757-0812-7_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0814-1

  • Online ISBN: 978-1-4757-0812-7

  • eBook Packages: Springer Book Archive

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