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Neurochemical Aspects of Schizophrenia

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Pathological Neurochemistry

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Abstract

Schizophrenia, a syndrome characterized by delusions, hallucinations, and disturbances of thought, is one of the most pervasive and socially disabling of all psychiatric disorders. Approximately 27% of annual psychiatric hospital admissions (340,000) in the United States are patients with this disorder,1 and most individuals with a chronic schizophrenic illness, if not institutionalized, are unemployable and spend years in community care facilities. Despite the severe morbidity and relatively high prevalence of this disorder in the general population (approximately 1%),2 its etiology remains unknown. In the postwar years, schizophrenia research focused on putative psychodynamic and socioenvironmental vulnerabilities for development of this disorder. Severely disordered mother-infant relationships as well as pathological communication patterns among family members were, in some psychiatric circles, considered important environmental inducers of schizophrenia. Terms such as “schizophrenigenic mother,”3 “double bind,” and “schism”4,5 were used to describe these pathological relationships. There is no doubt that disturbed relationships within some, but no all, families of schizophrenics are accurate observations, although how these stressors are associated with the etiology of schizophrenia remains obscure. Nevertheless, decreasing familial and other social stresses has been demonstrated to be an extremely important treatment strategy.6

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References

  1. Rosenstein, M. J., and Milazzo-Sayre, L. J., 1975, Mental Health Service System Reports, U.S. Department of Health and Human Services, NIMH, Division of Biometry and Epidemiology, Survey and Reports Branch, Rockville, Maryland, p. 45.

    Google Scholar 

  2. World Health Organization, 1975, Public Health Papers No. 63, Schizophrenia: A Multinational Study, World Health Organization, Geneva, pp. 35–38.

    Google Scholar 

  3. Fromm-Reichmann, F., 1948, Psychiatry 11:263–273.

    PubMed  CAS  Google Scholar 

  4. Lidz, T., Cornelison, A. R., Fleck, S., and Terry, D., 1957, Psychiatry 20:329–342.

    PubMed  CAS  Google Scholar 

  5. Singer, M. T., and Wynne, L. C., 1966, Psychiatr. Res. Rep. 20:25–38.

    CAS  Google Scholar 

  6. Keith, S. J., and Matthews, S. M., 1982, Psychiatry: 1982, The American Psychiatric Association Annual Review (L. Grinspoon, ed.), American Psychiatric Press, Washington, pp. 166–178.

    Google Scholar 

  7. Faucault, M., 1967, Madness and Civilization, Tavistock Publications, London.

    Google Scholar 

  8. Tusques, J., 1937, Sem. Hop. Paris 13:109–111.

    Google Scholar 

  9. Kalinowsky, L. B., and Hippius, H., 1969, Pharmacological, Convulsive, and Other Somatic Treatments in Psychiatry, Grunne & Stratton, New York.

    Google Scholar 

  10. Dorland’s Illustrated Medical Dictionary, 1965, (J. P. Friel, ed.), W. B. Saunders, Philadelphia.

    Google Scholar 

  11. Carlsson, A., 1978, Am. J. Psychiatry 135:164–173.

    CAS  Google Scholar 

  12. Rosenthal, D. and Kety, S. S., eds., 1968, The Transmission of Schizophrenia, Pergamon Press, Oxford.

    Google Scholar 

  13. Gottesman, I. I., and Shields, J., 1982, Schizophrenia: The Epigenetic Puzzle, Cambridge University Press, Cambridge.

    Google Scholar 

  14. Knox, W. E., 1972, The Metabolic Basis of Inherited Disease, 3rd edition (J. B. Stanbury, J. B. Wyngaarden, and D. S. Fredrickson, eds.), McGraw-Hill, New York, p. 266.

    Google Scholar 

  15. Teuber, H. L., 1972, Neurosci. Res. Prog. Bull. 10(4):381–388.

    CAS  Google Scholar 

  16. Penfield, W., and Jasper, G., 1954, Epilepsy and the Functional Anatomy of the Human Brain, Little, Brown, Boston.

    Google Scholar 

  17. Mullan, S., and Penfield, W., 1959, Arch. Neurol. Psychiatry 81:269–284.

    Article  CAS  Google Scholar 

  18. Bazhin, E. F., Wasserman, L. I., and Tonkonogii, I. M., 1975, Neuropsychologia 13:481–487.

    Article  PubMed  CAS  Google Scholar 

  19. Abrams, R., and Taylor, M. A., 1979, Arch. Gen. Psychiatry 36:1355–1358.

    Article  PubMed  CAS  Google Scholar 

  20. Flor-Henry, P., 1976, Ann. N.Y. Acad. Sci. 280:777–797.

    Article  PubMed  CAS  Google Scholar 

  21. Stevens, J. R., Bigelow, L., Denney, D., Lipkin, J., Livermore, A. H., Rauscher, F., Wyatt, R. J., 1979, Arch. Gen. Psychiatry 36:251–262.

    Article  PubMed  CAS  Google Scholar 

  22. Itil, T. M., 1977, Schizophren. Bull. 3:61–79.

    Article  CAS  Google Scholar 

  23. Fenton, G. W., Fenwick, P. B. C., Dollimore, J., Dunn, T. L., and Hirsch, S. R., 1980, Br. J. Psychiatry 136:445–455.

    Article  PubMed  CAS  Google Scholar 

  24. Buchsbaum, M. S., King, A. C., Cappelletti, J., Coppola, R., van Kammen, D. P., 1982, Adv. Biol. Psychiatry 9:50–56.

    Google Scholar 

  25. Malitz, S., Lozzi, V., and Kanzler, M., 1969, Schizophrenia: Current Concepts and Research (D. V. Siva Sankar, ed.), P. J. D. Publications, Hicksville, New York, pp. 273–302.

    Google Scholar 

  26. Buchsbaum, M. S., Ingvar, D. H., Kessler, R., Waters, R. N., Cappelletti, J., van Kammen, D. P., King, A. C., Johnson, J. L., Manning, R. G., Flynn, R. W., Mann, L. S., Bunney, W. E., and Sokoloff, L., 1982, Arch. Gen. Psychiatry 39:251–259.

    Article  PubMed  CAS  Google Scholar 

  27. Ingvar, D. H., and Frazen, G., 1974, Acta Psychiatr. Scand. 50:425–462.

    Article  PubMed  CAS  Google Scholar 

  28. DeLisi, L. E., and Buchsbaum, M. S. Biol. Psychiatry (in press).

    Google Scholar 

  29. Johnstone, E. C., Crow, T. J., Frith, C. D., Husband, J., and Kreel, L., 1976, Lancet 2:924–926.

    Article  PubMed  CAS  Google Scholar 

  30. Weinberger, D. R., and Wyatt, R. J., 1982, Biological Markers in Psychiatry and Neurology (I. Hanen and E. Usdin, eds.), Pergamon Press, New York, pp. 505–512.

    Google Scholar 

  31. Stevens, J. R., 1982, Arch. Gen. Psychiatry 39:1131–1139.

    Article  PubMed  CAS  Google Scholar 

  32. Fisman, M., 1975, Br. J. Psychiatry 126:414–422.

    Article  PubMed  CAS  Google Scholar 

  33. Kandel, E. R., and Schwartz, J. H., 1981, Principles of Neural Science, Elsevier/North-Holland, New York.

    Google Scholar 

  34. Cooper, J. R., Bloom, F. E., and Roth, R. H., 1982, The Biochemical Basis of Neuropharmacology, Oxford University Press, New York.

    Google Scholar 

  35. Young, D., and Scoville, W. B., 1938, Med. Clin. North Am. 22:637–646.

    Google Scholar 

  36. Connell, P. H., 1958, Maudsley Monographs No. 5., Oxford University Press, London.

    Google Scholar 

  37. Griffith, J. D., Cavanaugh, J. H., and Oates, J. A., 1970, Psychotomimetic Drugs (D. H. Efron, ed.), Raven Press, New York.

    Google Scholar 

  38. Janowsky, D., and Davies, J., 1976, Arch. Gen. Psychiatry 33:304–308.

    Article  PubMed  CAS  Google Scholar 

  39. Woodrow, K. M., Reifman, A., and Wyatt, R. J., 1978, Neuropharmacology and Behavior (B. Haber and M. H. Aprison, eds.), Plenum Press, New York, pp. 1–22.

    Chapter  Google Scholar 

  40. Wyatt, R. J., Potkin, S. G., Kleinman, J. E., Weinberger, D. R., Luchins, D. L., and Jeste, D. V., 1981, J. Nerv. Ment. Dis. 169:100–112.

    Article  PubMed  CAS  Google Scholar 

  41. van Kammen, D. P., Bunney, W. E., Docherty, J. P., Marder, S. R., Ebert, M. H., Rosenblatt, J. E., and Rayner, J. N., 1982, Am. J. Psychiatry 139:991–997.

    PubMed  Google Scholar 

  42. Frye, P. E., Pariser, S. F., Kim, M., and O’Shaughnessy, R. W., 1982, J. Clin. Psychiatry 43:252–253.

    PubMed  CAS  Google Scholar 

  43. Carlsson, A., 1974, J. Psychiatr. Res. 11:57–64.

    Article  PubMed  CAS  Google Scholar 

  44. Corsini, G. U., Del Zompo, M., Manconi, S., Piccardi, M. P., Onali, P. L., and Mangoni, A., 1977, Adv. Biochem. Psychopharmacol. 16:645–648.

    PubMed  CAS  Google Scholar 

  45. Smith, R. C., Tamminga, C., and Davis, J. M., 1977, J. Neural Transm. 40(2):171–176.

    Article  PubMed  CAS  Google Scholar 

  46. Tamminga, C. A., Schaffer, M. H., Smith, R. C., and Davis, J. M., 1978, Science 200(4341):567–568.

    Article  PubMed  CAS  Google Scholar 

  47. Bird, E. D., Crow, T. J., Iverson, L. L., Longden, A., Mackay, A. V. P., Riley, G. J., and Spokes, E. C., 1979 J. Physiol. (Lond.) 293:36–37P.

    Google Scholar 

  48. Kleinman, J. E., Karoum, F., Rosenblatt, J. E., Gillin, J. C., Hong, J., Bridge, T. P., Zalcman, S., Storch, F., del Carmen, R., and Wyatt, R. J., 1982, Biological Markers in Psychiatry and Neurology (I. Hanin and E. Usdin, eds.), Pergamon Press, Oxford, pp. 67–78.

    Google Scholar 

  49. Bird, E. D., Spokes, E. G., Barnes, J., Mackay, A., Iversen, L., and Shepherd, M., 1977, Lancet 2:1157–1159.

    Article  PubMed  CAS  Google Scholar 

  50. Owen, F., Cross, A. J., Crow, T. J., Longden, A., Poulter, M., and Riley, G. J., 1978, Lancet 2:223–225.

    Article  PubMed  CAS  Google Scholar 

  51. Bird, E. D., Spokes, E. G., and Iversen, L. L., 1979, Science 204:93–94.

    Article  PubMed  CAS  Google Scholar 

  52. Mackay, A. V. P., Iverson, L. L., Rossor, M., Spokes, E., Bird, E., Arregui, A., Creese, I., and Snyder, S. H., 1982, Arch. Gen. Psychiatry 39:991–997.

    Article  PubMed  CAS  Google Scholar 

  53. Lee, T., and Seeman, P., 1980, Am. J. Psychiatry 137:191–197.

    PubMed  CAS  Google Scholar 

  54. Schwartz, J. C., Baudry, M., Markes, M. P., Costentin, J., and Protais, P., 1978, Life Sci. 23:1785–1790.

    Article  PubMed  CAS  Google Scholar 

  55. Crow, T. J., Cross, A. J., Johnstone, E. C., and Owen, F., 1982, Schizophrenia As a Brain Disease (F. A. Henn and H. A. Nasrallah, eds.), Oxford University Press, New York, pp. 196–234.

    Google Scholar 

  56. Burt, D. R., Creese, I., and Snyder, S. H., 1977, Science 197:326–328.

    Article  Google Scholar 

  57. Clow, A., Theodorou, A., Jenner, P., and Marsden, C. D., 1980, Eur. J. Pharmacol. 63:135–144.

    Article  PubMed  CAS  Google Scholar 

  58. Owen, F., Cross, A. J., Waddington, J. L., Poulter, M., Gamble, S. J., and Crow, T. J., 1980, Life Sci. 26:55–59.

    Article  PubMed  CAS  Google Scholar 

  59. Reisine, T. D., Fields, J. Z., Bird, E. D., Spokes, E., and Yamamura, H. I., 1978, Commun. Psychopharmacol. 2:79–84.

    PubMed  CAS  Google Scholar 

  60. Haracz, J. L., 1982, Schizophren. Bull. 8:438–469.

    Article  CAS  Google Scholar 

  61. Muller, E. E., Nistico, G., and Scapagini, E., 1977, Neurotransmitters and Anterior Pituitary Function, Academic Press, New York.

    Google Scholar 

  62. Meltzer, H. Y., and Fang, V. S., 1976, Arch. Gen. Psychiatry 33:279–286.

    Article  PubMed  CAS  Google Scholar 

  63. Laughren, T. P., Brown, W. A., and Williams, B. W., 1979, Am. J. Psychiatry 136:108–110.

    PubMed  CAS  Google Scholar 

  64. Brown, W. A., and Laughren, T. P., 1981, Am. J. Psychiatry 138:237–239.

    PubMed  CAS  Google Scholar 

  65. Meltzer, H. Y., Sachar, E. J., and Frantz, A. G., 1974, Arch. Gen. Psychiatry 31:564–569.

    Article  PubMed  CAS  Google Scholar 

  66. Mackay, A. V. P., 1980, Br. J. Psychiatry 137:379–383.

    Article  PubMed  CAS  Google Scholar 

  67. Chouinard, G., and Jones, B. D., 1978, Lancet 2:99–100.

    Article  PubMed  CAS  Google Scholar 

  68. Wyatt, R. J., 1984, The Stanley R. Dean Research Aware Lecture (in press).

    Google Scholar 

  69. Crow, T. J., 1980, Br. Med. J. 280:66–68.

    Article  PubMed  CAS  Google Scholar 

  70. Crow, T. J., 1981, Br. J. Psychiatry 139:251–254.

    Article  PubMed  CAS  Google Scholar 

  71. Kleinman, J. E., Weinberger, D. R., Rogol, D. A., Bigelow, L. B., Klein, S. T., and Wyatt, R. J., 1982, Arch. Gen. Psychiatry 39:655–657.

    Article  PubMed  CAS  Google Scholar 

  72. Andreasen, N. C., Olsen, S. A., Dennert, J. W., and Smith, M. R., 1982, Am. J. Psychiatry 132:297–302.

    Google Scholar 

  73. Jeste, D. V., Zalcman, S., Weinberger, D. R., Bigelow, L. B., Kleinman, J. E., Rogol, A., Gillin, J. C., and Wyatt, R. J., 1983, Prog. Neuropsychopharmacol. Biol. Psychiatry 7:83–88.

    Article  PubMed  CAS  Google Scholar 

  74. Wise, R. A., 1982, Behav. Brain Sci. 5:39–87.

    Article  Google Scholar 

  75. Siegfried, B., and Bures, J., 1979, Brain Res. 167:139–155.

    Article  PubMed  CAS  Google Scholar 

  76. Fink, S. J., and Smith, G. P., 1980, Brain Res. 199:359–384.

    Article  PubMed  CAS  Google Scholar 

  77. Wooley, D. W., and Shaw, E., 1953, Proc. Natl. Acad. Sci. U.S.A. 40(4):228–231.

    Article  Google Scholar 

  78. Wooley, D. W., 1962, The Biochemical Bases of Psychoses or the Serotonin Hypotheses about Mental Illness, John Wiley and Sons, New York, pp. 168–179.

    Google Scholar 

  79. Haverback, B. J., Sjoerdsma, A., and Terry, L. L., 1956, N. Engl. J. Med. 255:270–274.

    Article  PubMed  CAS  Google Scholar 

  80. Feldstein, A., Hoagland, H., and Freeman, H., 1958, Science 128:358.

    Article  PubMed  CAS  Google Scholar 

  81. Toh, C. C., 1954, J. Physiol. (Lond.) 126:248–254.

    CAS  Google Scholar 

  82. Garelis, E., Gillin, J. C., Wyatt, R. J., and Neff, N., 1975, Am. J. Psychiatry 132:184–186.

    PubMed  CAS  Google Scholar 

  83. DeLisi, L. E., Neckers, L. M., Weinberger, D. R., and Wyatt, R. J., 1981, Arch. Gen. Psychiatry 38:647–654.

    Article  PubMed  CAS  Google Scholar 

  84. Freedman, D. X., Belenduik, K., Belenduik, G. W., and Crayton, J. W., 1981, Arch. Gen. Pscyhiatry 38:655–659.

    Article  CAS  Google Scholar 

  85. Feldstein, A., Hoagland, H., and Freeman, H., 1959, J. Nerv. Ment. Dis. 129:62–68.

    Article  PubMed  CAS  Google Scholar 

  86. Jus, A., Laskowska, D., and Zimny, S., 1958, Ann. Med. Psychol. (Paris) 116:898–913.

    CAS  Google Scholar 

  87. Coleman, M., Hart, P. N., and Randall, J., 1977, Neuropaediatrie 8:459–466.

    Article  CAS  Google Scholar 

  88. Post, R. M., Ballenger, J. C., and Goodwin, F. K., 1980, Neurobiology of Cerebrospinal Fluid (J. H. Wood, ed.), Plenum Press, New York, pp. 685–717.

    Chapter  Google Scholar 

  89. Potkin, S. G., Weinberger, D. R., Linnoila, M., and Wyatt, R. J., 1983, Am. J. Psychiatry 140:21–25.

    PubMed  CAS  Google Scholar 

  90. Joseph, M. H., Baker, H. F., Crow, T. J., Riley, G. J., and Risby, D., 1979, Psychophar-macology 62:279–275.

    Article  CAS  Google Scholar 

  91. Crow, T. J., Baker, H. F., Cross, A. J., Joseph, M. H., Lofthouse, R., Longden, A., Owen, F., Riley, G. J., Glover, V., and Killpack, W. S., 1979, Br. J. Psychiatry 134:249–256.

    Article  PubMed  CAS  Google Scholar 

  92. Farley, I. J., Shannak, K. S., and Hornykiewicz, O., 1980, Receptors for Neurotransmitters and Peptides Hormones (G. Pepeu, M. J. Kuhar, and S. J. Enna, eds.), Raven Press, New York, pp. 427–433.

    Google Scholar 

  93. Winblad, B., Bucht, G., Gottfries, C. G., and Roos, B. E., 1979, Acta Psychiatr. Scand. 60:17–28.

    Article  PubMed  CAS  Google Scholar 

  94. Ahtee, L., and Paasonen, M. K., 1968, Ann. Mod. Exp. Biol. Fenn. 46:416–422.

    Google Scholar 

  95. Todrick, A., and Tait, A. C., 1969, J. Pharm. Pharmacol. 21:751–762.

    Article  PubMed  CAS  Google Scholar 

  96. Oxenkrug, G. F., 1978, J. Pharm. Pharmacol. 30:740.

    Article  PubMed  CAS  Google Scholar 

  97. Bacopoulos, N. G., Redmond, D. E., and Roth, R. H., 1979, J. Neurochem. 32(4): 1215–1218.

    Article  PubMed  CAS  Google Scholar 

  98. Lauer, J. W., Inskip, W. M., Bernsohn, J., and Zeller, E. A., 1958, Arch. Neurol. Psychiatry 80(1): 122–130.

    Article  CAS  Google Scholar 

  99. Kopin, I. J., 1959, Science 129:(3352):835–836.

    Article  PubMed  CAS  Google Scholar 

  100. Shaw, C. R., Lucas, J., and Rabinovitch, R. D., 1959, Arch. Gen. Psychiatry 1(4):366–371.

    Article  CAS  Google Scholar 

  101. Wooley, D. W., 1962, The Biochemical Bases of Psychoses or the Serotonin Hypothesis about Mental Illness, New York, John Wiley and Sons, pp. 168–170.

    Google Scholar 

  102. Klee, G. D., Bertino, J., Goodman, A., and Aronson, H., 1961, J. Ment. Sci. 106(442):309–316.

    Google Scholar 

  103. Hoagland, H., 1958, J. Nerv. Ment. Dis. 126(3):211–220.

    Article  PubMed  CAS  Google Scholar 

  104. Pollin, W., Cardon, P. V., Jr., and Kety, S. S., 1961, Science 133(3446): 104–105.

    Article  PubMed  CAS  Google Scholar 

  105. Bigelow, L. B., Walls, P., Gillin, J. C., and Wyatt, R. J., 1979, Biol. Psychiatry 14:53–67.

    PubMed  CAS  Google Scholar 

  106. Sherwood, S. L., 1955, Proc. R. Soc. Med. 48(10):855–863.

    CAS  Google Scholar 

  107. Ljungberg, E., 1963, West Eur. Symp. Clin. Chem. 2:169–170.

    Google Scholar 

  108. DeLisi, L. E., Freed, W. J., Gillin, J. C., Kleinman, J. E., and Wyatt, R. J., 1982, Biol. Psychiatry 17:471–477.

    PubMed  CAS  Google Scholar 

  109. Crow, T. J., Spear, P. J., and Arbuthnott, G. W., 1972, Brain Res. 36:275–287.

    Article  PubMed  CAS  Google Scholar 

  110. Stein, L., and Wise, C. D., 1971, Science 171(3975): 1032–1036.

    Article  PubMed  CAS  Google Scholar 

  111. Wise, C. D., and Stein, L., 1973, Science 181:344–347.

    Article  PubMed  CAS  Google Scholar 

  112. Wise, C. D., Baden, M. M., and Stein, L., 1974, J. Psychiatr. Res. 11:185–198.

    Article  PubMed  CAS  Google Scholar 

  113. Wyatt, R. J., Schwartz, M. D., Erdelyi, E., and Barchas, J. D., 1975, Science 187:368–369.

    Article  PubMed  CAS  Google Scholar 

  114. Cross, A. J., Crow, T. J., Killpack, W. S., London, A., Owen, F., and Riley, G. L., 1978, Psychopharmacology 59:117–121.

    Article  PubMed  CAS  Google Scholar 

  115. Creese, I., Burt, D. R., and Snyder, S. H., 1976, Science 192:481–483.

    Article  PubMed  CAS  Google Scholar 

  116. Seeman, P., Lee, T., Chan-Wong, M., and Wong, K., 1976, Nature 261:717–719.

    Article  PubMed  CAS  Google Scholar 

  117. Snyder, S. H., 1976, Am. J. Psychiatry 133:197–202.

    PubMed  CAS  Google Scholar 

  118. Blumberg, J. B., Vetulani, J., Stawarz, R. J., and Sulser, F., 1976, Eur. J. Pharmacol. 37(2):357–366.

    Article  PubMed  CAS  Google Scholar 

  119. Farley, I. J., Price, K. S., McCullough, E., Deck, J. H. N., Hordynski, W., and Hornykiewicz, O., 1978, Science 200:456–458.

    Article  PubMed  CAS  Google Scholar 

  120. Crow, T. J., Owen, F., Cross, A. J., Lofthourse, R., and Longden, A., 1978, Lancet 1:36–37.

    Google Scholar 

  121. Bird, E. D., Spokes, E. G., and Iverson, L. L., 1979, Science 204:93–94.

    Article  PubMed  CAS  Google Scholar 

  122. Carlsson, A., 1979, Catecholamines: Basic and Clinical Frontiers, Volume 1 (E. Usdin, I. J. Kopin, and J. D. Barchas, eds.), Pergamon Press, New York, pp. 4–19.

    Google Scholar 

  123. Gomes, V. C. R., Shanley, B. C., Potgieter, L., and Roux, J. T., 1980, Br. J. Psychiatry 137:346–351.

    Article  PubMed  CAS  Google Scholar 

  124. Lake, C. R., Sternberg, D. E., van Kammen, D. P., Ballenger, J. C., Ziegler, M. G., Post, R. M., Kopin, I. J., and Bunney, W. E., 1980, Science 207:331–333.

    Article  PubMed  CAS  Google Scholar 

  125. Kemali, D., Vecchio, M. D., and Maj, M., 1982, Biol. Psychiatry 17:711–717.

    PubMed  CAS  Google Scholar 

  126. Kafka, M. S., van Kammen, D. B., Kleinman, J. E., Nurenberger, J. I., Siever, L. J., Uhde, T. W., and Polinsky, R. J., 1982, Commun. Psychopharmacol. 4(6):477–486.

    Google Scholar 

  127. Naber, D., Finkbeiner, C., Fischer, B., Zander, K. J., and Ackenheil, M., 1980, Neurop-sychobiology 6:181–189.

    Article  CAS  Google Scholar 

  128. Sternberg, D. E., van Kammen, D. P., Lake, C. R., Ballenger, J. C., Marder, S. R., and Bunney, W. E., 1981, Am. J. Psychiatry 138:1045–1050.

    PubMed  CAS  Google Scholar 

  129. Freedman, R., Bell, J., and Kirch, D., 1980, Am. J. Psychiatry 137(5):629–630.

    PubMed  CAS  Google Scholar 

  130. Ko, G., 1983, Abstr. Am. Psychiatr. Assoc.

    Google Scholar 

  131. Davis, J. M., Janicak, P., Chang, S., and Klerman, K., 1982, Psychiatry 1982: Annual Review, American Psychiatric Press, Washington, pp. 178–228.

    Google Scholar 

  132. Peet, M., Middlemiss, D. N., and Yates, R. A., 1980, Lancet 2(8201):978.

    Article  PubMed  CAS  Google Scholar 

  133. Awapara, J., 1950, Fed. Proc. 9:148.

    Google Scholar 

  134. Roberts, E., and Frankel, S., 1950, Fed. Proc. 9:219.

    Google Scholar 

  135. Snyder, S. H., 1975, Biochem. Pharmacol. 24:1371–1374.

    Article  CAS  Google Scholar 

  136. Baxter, C., 1976, GABA in Nervous System Function (E. Roberts, T. N. Chase, and D. B. Tower, eds.), Raven Press, New York, pp. 61–87.

    Google Scholar 

  137. Yoshida, M., and Precht, W., 1971, Brain Res. 32:225–228.

    Article  PubMed  CAS  Google Scholar 

  138. Fuxe, K., Perez de la Mora, M., Hokfelt, T., Agnati, L., Ljungdahl, A., and Johanson, O.,1977, Psychopathology and Brain Dysfunction (C. Shagass, S. Gershon, and A. J. Friedhoff, eds.), Raven Press, New York, pp. 97–111.

    Google Scholar 

  139. Roberts, E., 1972, Neurosci. Res. Prog. Bull. 10:468–483.

    CAS  Google Scholar 

  140. Cross, A. J., Crow, T. J., and Owen, F., 1979, Lancet 1:560–561.

    Article  PubMed  CAS  Google Scholar 

  141. Bennett, J. P., Enna, S. J., Bylund, D. B., Gillin, J. C., Wyatt, R. J., and Synder, S. H., 1979, Arch. Gen. Psychiatry 36:927–934.

    Article  PubMed  CAS  Google Scholar 

  142. Iversen, L. L., Bird, E., and Spokes, E., 1979, GABA-Neurotransmitters: Pharmacochem-ical, Biochemical and Pharmacological Aspects (P. Krogsgaard-Larsen, J. Scheel-Kruger, H. Kofod, eds.), Academic Press, New York, pp. 177–190.

    Google Scholar 

  143. Petty, T. L., Kish, S. J., Buchanan, J., and Hansen, S., 1979, Lancet 1:237.

    Google Scholar 

  144. Gold, B. I., Bowers, M. B., Jr., Roth, R. H., and Sweeney, D. W., 1980, Am. J. Psychiatry 137:362–364.

    PubMed  CAS  Google Scholar 

  145. Lichtshtein, D., Dobkin, J., Ebstein, R. P., Biederman, J., Rimon, R., and Belmaker, R. H.,1978, Br. J. Psychiatry 132:145–148.

    Article  PubMed  CAS  Google Scholar 

  146. van Kammen, D. P., Steinberg, D. E., Hare, T. A., Waters, R. N., Bunney, W. E., 1982, Arch. Gen. Psychiatry 39:91–97.

    Article  PubMed  Google Scholar 

  147. McCarthy, B. W., Gomes, U. R., Neethling, A. C., Shanley, B. C., Talgaard, J. J., Potgieter, L., and Roux, S. T., 1981, J. Neurochem. 36(4): 1406–1408.

    Article  PubMed  CAS  Google Scholar 

  148. Tamminga, C. A., Crayton, J. W., and Chase, T. N., 1978, Am. J. Psychiatry 135:746–747.

    PubMed  CAS  Google Scholar 

  149. Schulz, S. C., van Kammen, D. P., Buchsbaum, M. S., Roth, R. H., Alexander, P., and Bunney, W. E., Jr., 1981, Pharmacopsychiatria 14:129–134.

    Article  PubMed  CAS  Google Scholar 

  150. Simpson, G. M., Branchex, M. M., and Shrivastava, R. K., 1975, Lancet 1:966–967.

    Google Scholar 

  151. Tallman, J. F., Paul, S. M., Skolnick, P., and Gallager, D. W., 1980, Science 207:274–281.

    Article  PubMed  CAS  Google Scholar 

  152. Jimerson, D. C., van Kammen, D. P., Post, R. M., Docherty, J. P., and Bunney, W. E., 1982, Am. J. Psychiatry 139:489–491.

    PubMed  CAS  Google Scholar 

  153. Beckmann, H., and Haas, S., 1980, Psychopharmacology 71:79–82.

    Article  PubMed  CAS  Google Scholar 

  154. Lingjaerde, O., 1982, Acta Psychiatr. Scand. 65:339–354.

    Article  PubMed  CAS  Google Scholar 

  155. Wikler, A., 1952, Public Health Monograph No. 52, U. S. Dept. of Health, Education and Welfare, Washington.

    Google Scholar 

  156. Watson, S. J., Akil, H., Berger, P. A., and Barchas, J. D., 1979, Arch. Gen. Psychiatry 36:35–41.

    Article  PubMed  CAS  Google Scholar 

  157. Berger, P. A., Watson, S. J., Akil, H., Elliot, G. R., Rubin, R. T., Pfefferbaum, A., Davis, K. L., Barchas, J. D., and Li, C. H., 1980, Arch. Gen. Psychiatry 37:635–640.

    Article  PubMed  CAS  Google Scholar 

  158. Bloom, F., Segal, D., Ling, N., and Guillemin, R., 1976, Science 194:630.

    Article  PubMed  CAS  Google Scholar 

  159. Jacquet, Y., and Marks, N., 1976, Science 194:632.

    Article  PubMed  CAS  Google Scholar 

  160. Lindstrom, L. H., Widerlow, E., Gunne, L. M., Wahlstrom, A., and Terenius, L., 1978, Acta Psychiatr. Scand. 57:153–164.

    Article  PubMed  CAS  Google Scholar 

  161. Domschke, W., Dickschas, A., and Mitznegg, P., 1979, Lancet 1:1024.

    Article  PubMed  CAS  Google Scholar 

  162. Terenius, L., Wahlstrom, A., Lindstrom, L., and Widerlou, E., 1976, Neurosci. Lett. 3:157–162.

    Article  PubMed  CAS  Google Scholar 

  163. Pickar, D., Cohen, M. R., Naber, D., and Cohen, R. M., 1982, Biol. Psychiatry 17:1243–1276.

    PubMed  CAS  Google Scholar 

  164. Gunne, L. M., Lindstrom, L., and Terenius, L., 1977, J. Neural Transm. 40:13–19.

    Article  PubMed  CAS  Google Scholar 

  165. Berger, P., Watson, S., Akil, H., and Barchas, J., 1981, Am. J. Psychiatry 138:913–915.

    PubMed  CAS  Google Scholar 

  166. Lehman, H., Nair, N. P. V., and Kline, N. S., 1979, Am. J. Psychiatry 136:762–766.

    Google Scholar 

  167. Pickar, D., Vartanian, F., Bunney, W. E., Maier, H. P., Gastpar, M. T., Prakash, R., Sethi, B. B., Lideman, R., Belyaer, B. S., Tsutsulkovskaja, M. V. A., Jungkunz, G., Nedopil, N., Verhoeven, W., and van Praag, H., 1982, Arch. Gen. Psychiatry 39:313–319.

    Article  PubMed  CAS  Google Scholar 

  168. Davis, G. L., and Bunney, W. E., Jr., 1980, Neural Peptides and Neuronal Communication (E. Costa and M. Trabucchi, eds.), Raven Press, New York, pp. 455–464.

    Google Scholar 

  169. Kline, N. S., Li, C. H., Lehmann, H. E., Lajtha, A., Laski, E., and Cooper, T., 1977, Arch. Gen. Psychiatry 34:1111–1113.

    Article  PubMed  CAS  Google Scholar 

  170. Gerner, R. H., Catlin, D. H., Gorelick, D. A., Hui, K. K., and Li, C. H., 1980, Arch. Gen. Psychiatry 73:642–647.

    Article  Google Scholar 

  171. Pickar, D., Davis, G. C., Schulz, C., Exstein, I., Wagner, R., Naber, D., Gold, P. W., van Kammen, D. P., Goodwin, F. K., Wyatt, R. J., Li, C. H., and Bunney, W. E., 1981, Am. J. Psychiatry 138:160–166.

    PubMed  CAS  Google Scholar 

  172. Verhoeven, W. M. A., van Praag, H. M., van Ree, J. M., and de Wied, D., 1979, Arch. Gen. Psychiatry 36:294–298.

    Article  PubMed  CAS  Google Scholar 

  173. Meltzer, H. Y., Busch, D. A., Tricou, B. J., and Robertson, A., 1982, Psychiatr. Res. 6(3):313–326.

    Article  CAS  Google Scholar 

  174. Tamminga, C. A., Tighe, P. J., Chase, T. N., De Fraites, E. G., and Shaffer, M. H., 1981, Arch. Gen. Psychiatry 38:167–174.

    Article  PubMed  CAS  Google Scholar 

  175. Jorgenson, A., Fog, R., and Veilisi, B., 1979, Lancet 1:935.

    Article  Google Scholar 

  176. Hökfelt, T., Skirboll, L., Rehfeld, J. F., Goldstein, M., Markey, K., and Dann, O., 1980, Neuroscience 5(12):2093–2124.

    Article  PubMed  Google Scholar 

  177. Crow, T. J., 1982, Abstracts of the Annual meeting of the American College of Psycho-pharmacology, ACNP, Inc., Vanderbilt University, Nashville, p. 28.

    Google Scholar 

  178. Kleinman, J. E., Hong, J., Gellin, J. C., Govoni, S., and Wyatt, R. J., 1982, Abstract of the Annual Meeting of the American College of Neuropsychopharmacology, p. 28.

    Google Scholar 

  179. Nair, N. P., Bloom, D. M., and Nestoros, J. N., 1982, Prog. Neuropsychopharmacol. Biol. Psychiatry 6:509–512.

    Article  PubMed  CAS  Google Scholar 

  180. Morogi, T., Watanabe, N., Aoki, N., and Itoh, S., 1982, Arch. Gen. Psychiatry 39:485–486.

    Article  Google Scholar 

  181. Osmond, H., and Smythies, J., 1952, J. Ment. Sci. 98:309–315.

    PubMed  CAS  Google Scholar 

  182. Kety, S. S., 1967, Amines and Schizophrenia (H. E. Himwich, S. S. Kety, and J. R. Smythies, eds.), Pergamon Press, Oxford, pp. 271–277.

    Google Scholar 

  183. Wyatt, R. J., Termini, B. A., and Davis, J., 1971, Schizophren. Bull 4:10–44.

    Article  Google Scholar 

  184. Pollin, W., Cardon, P. V., Jr., and Kety, S. S., 1961, Science 133:104–105.

    Article  PubMed  CAS  Google Scholar 

  185. Brune, G. C., and Himwvich, H. E., 1962, J. Nerv. Ment. Dis. 137:447–450.

    Article  Google Scholar 

  186. Alexander, F., Curtis, G. C., Sprince, H., and Crosley, A. P. J., 1963, J. Nerv. Ment. Dis. 137:135–142.

    Article  PubMed  CAS  Google Scholar 

  187. Antun, F. T., Burnett, G. B., Cooper, A. J., Daly, R. J., Smythies, J. R., and Zealley, A. K., 1971, J. Psychiatr. Res. 8:63–71.

    Article  PubMed  CAS  Google Scholar 

  188. Antun, F. T., and Kurkjian, R., 1982, Br. J. Psychiatry 140:611–614.

    Article  PubMed  CAS  Google Scholar 

  189. Pscheidt, G. R., Beriet, H. H., Spaide, J., and Himwich, H. E., 1961, Clin. Chim. Acta 13:229–334.

    Google Scholar 

  190. Kline, M. S., 1967, Br. J. Psychiatry 113:731–742.

    Article  PubMed  CAS  Google Scholar 

  191. Meltzer, H., Shader, R., and Grinspoon, L., 1969, Psychopharmacologia 15:144–152.

    Article  PubMed  CAS  Google Scholar 

  192. Friedhoff, A. J., and Van Winkle, E., 1962, Nature 194:897–898.

    Article  CAS  Google Scholar 

  193. Szara, S., 1956, Experientia 12:441–442.

    Article  PubMed  CAS  Google Scholar 

  194. Franzen, F., and Gross, H., 1965, Nature 206:1052.

    Article  PubMed  CAS  Google Scholar 

  195. Checkley, S. A., Murray, R. M., Oon, M. C. H., Rodnight, R., and Birley, J. L. T., 1980, Br. J. Psychiatry 137:236–239.

    Article  PubMed  CAS  Google Scholar 

  196. Gillin, J. C., Kaplan, J., Stillman, R., and Wyatt, R. J., 1976, Am. J. Psychiatry 133:203–208.

    PubMed  CAS  Google Scholar 

  197. Wyatt, R. J., Saavedra, J. M., and Axelrod, J., 1973, Am. J. Psychiatry 130:754–760.

    PubMed  CAS  Google Scholar 

  198. Mandel, L. R., Ahn, H. S., and Vandenheuvel, W. J., 1972, Biochem. Pharmacol. 21:1197–1200.

    Article  PubMed  CAS  Google Scholar 

  199. Mandel, L. R., Prasad, R., Lopez-Ramos, B., and Walker, R. W., 1977, Res. Commun. Chem. Pathol. Pharmacol. 16:47–58.

    PubMed  CAS  Google Scholar 

  200. Walker, R. W., Mandel, L. R., DeLisi, L. E., Wyatt, R. J., and Vandenheuvel, W. J. A., 1983, Abstracts of the International Symposium on Advances in Chromatography, Amsterdam.

    Google Scholar 

  201. Frohman, C. E., Latham, K. L., Beckett, P. G. S., and Gottlieb, J. S., 1960, Arch. Gen. Psychiatry 2:255–262.

    Article  CAS  Google Scholar 

  202. Frohman, C. E., Harmison, C. R., Arthur, R. E., and Gottlieb, J. S., 1971, Biol. Psychiatry 3:113–121.

    PubMed  CAS  Google Scholar 

  203. Frohman, C. E., Arthur, R. E., and Gottlieb, J. S., 1973, Biol. Psychiatry 7:53–61.

    PubMed  CAS  Google Scholar 

  204. Sandler, M., and Reynolds, G. P., 1976, Lancet 1:70–71.

    Article  PubMed  CAS  Google Scholar 

  205. Wyatt, R. J., Gillin, J. C., Stoff, D. M., Moja, E. A., and Tinklenberg, J. H., 1977, Neu-roregulators and Psychiatric Disorders (E. Usdin, J. Barchas, and D. Hamburg, eds.), Oxford University Press, New York, pp. 31–45.

    Google Scholar 

  206. Moja, E. A., Stoff, D. M., Gillin, J. C., and Wyatt, R. J., 1978, Biol. Psychiatry 13:291–295.

    PubMed  CAS  Google Scholar 

  207. Fischer, E., Spatz, H., Saavedra, J. M., Reggiani, H., Mira, A., and Heller, B., 1972, Biol. Psychiatry 5:139–147.

    PubMed  CAS  Google Scholar 

  208. Fischer, E., Heller, B., and Miro, A. H., 1968, Arzneim. Forsch. 18:1486.

    CAS  Google Scholar 

  209. Potkin, S., Karoum, F., Chuang, L. W., Cannon-Spoor, E., Philips, I., and Wyatt, R. J., 1979, Science 206:470–471.

    Article  PubMed  CAS  Google Scholar 

  210. Jeste, D. V., Doongaji, D. R., Panjwani, D., Datta, M., Potkin, S. G., Karoum, F., Thatle, S., Sheth, A. S., Apte, J. S., and Wyatt, R. J., 1981, Psychiatr. Res. 5:341–352.

    Article  CAS  Google Scholar 

  211. Paulos, M. A., and Tessel, R. E., 1982, Science 215:1127–1129.

    Article  PubMed  CAS  Google Scholar 

  212. Karoum, F., Linnoila, M., Potter, W. Z., Chuang, L. W., Goodwin, F. K., and Wyatt, R. J., 1982, Psychiatry Res. 6:215–222.

    Article  PubMed  CAS  Google Scholar 

  213. DeLisi, L. E., Murphy, D., Karoum, F., Targum, S., and Wyatt, R. J., 1984, Psychiatry Res. (in press).

    Google Scholar 

  214. Sabelli, H. C., and Borison, R. L., 1976, Advances in Biochemical Psychopharmacology, Volume 15 (E. Costa, E. Ciacobini, and R. Paoletti, eds.), Raven Press, New York, pp. 75–86.

    Google Scholar 

  215. Linnoila, M., Potter, W., Potkin, S. G., and Wyatt, R. J., 1984, Br. J. Psychiatry 144:428–431.

    Article  PubMed  CAS  Google Scholar 

  216. Heath, R. G., Martens, S., Leach, B. E., Cohen, M., and Angel, C., 1957, Am. J. Psychiatry 114:14–24.

    PubMed  CAS  Google Scholar 

  217. Heath, R. G., Guschwan, A. F., and Coffey, J. W., 1970, Dis. Nerv. Syst. 31:391–395.

    PubMed  CAS  Google Scholar 

  218. Heath, R. G., and Krupp, I. M., 1967, Arch. Gen. Psychiatry 16:1–9.

    Article  PubMed  CAS  Google Scholar 

  219. Robins, E., 1957, Neuropharmacology (H. S. Abramson, ed.), Josiah Macy, Jr., Foundation, New York, p. 123.

    Google Scholar 

  220. Siegal, M., Niswander, C. D., Sachs, E., Jr., and Stavros, D., 1959, Am. J. Psychiatry 115:819.

    Google Scholar 

  221. Bergen, J. R., Grinspoon, L., Pyle, H. M., Martinez, J. L., and Pennell, R. B., 1980, Biol. Psychiatry 15:369–379.

    PubMed  CAS  Google Scholar 

  222. Martens, S., Vallbo, S., and Melander, B., 1959, Acta Psychiat. Neurol. Scand. Suppl. 136:361.

    Article  Google Scholar 

  223. Meckler L. B., Lapteva, N. N., Lozovskii, D. V., and Balezinc, T. I., 1960, Proc. Acad. Sci. SSSR 130:1148.

    Google Scholar 

  224. Nelson, J. W., Daniels, E. G., Mann, K. M., and Kinman, J. W., 1963, Serological Fractions in Schizophrenia (R. G. Heath, ed.), Hoeber Medical Division, Harper and Row, New York, pp. 43–56.

    Google Scholar 

  225. Boehme, D. H., Cottrell, J. C., Dohan, F. C., and Hillegass, L. M., 1974, Biol. Psychiatry 8(1):89–94.

    PubMed  CAS  Google Scholar 

  226. Hirata-Hibi, M., Higashi, S., Tachibana, T., and Watanabe, N., Arch. Gen. Psychiatry 39:82–87.

    Google Scholar 

  227. Vartanian, M. E., Koliaskina, G. I., Lozovsky, D. V., Burbaeva, G. S., and Ignator, S. A., 1978, Birth Defects 14:339–364.

    PubMed  CAS  Google Scholar 

  228. Liedeman, R. R., and Prilipko, L. L., 1978, Birth Defects 14:365–377.

    PubMed  CAS  Google Scholar 

  229. Zarrabi, M. H., Zucker, S., Miller, F., Derman, R. M., Romeno, G. S., Hartnett, J. A., and Varma, A. O., 1979, Ann. Intern. Med. 91:194–199.

    PubMed  CAS  Google Scholar 

  230. DeLisi, L. E., Goodman, S., Neckers, L. M., and Wyatt, R. J., 1982, Biol. Psychiatry 17(9):1003–1007.

    PubMed  CAS  Google Scholar 

  231. Coffey, C. E., Sullivan, J. L., and Rice, J. R., 1983, Biol. Psychiatry 18:113–119.

    PubMed  CAS  Google Scholar 

  232. McGuffin, P., 1979, Psychol. Med. 9:721–728.

    Article  PubMed  CAS  Google Scholar 

  233. McGuffin, P., Farmer, A. E., and Yonace, A. H., 1981, Psychol. Res. 5:115–122.

    CAS  Google Scholar 

  234. Luchins, D. J., Weinberger, D. R., Zalcman, S., DeLisi, L. E., Rogentine, N., and Wyatt, R. J., 1980, Br. J. Psychiatry 136:243–248.

    Article  PubMed  CAS  Google Scholar 

  235. Smeraldi, E., Sacchetti, E., and Cazzullo, C. L., 1976, Br. J. Psychiatry 129:486–489.

    Article  PubMed  CAS  Google Scholar 

  236. APA Task Force Report 7, 1973, Megavitamin and Orthomolecular Therapy in Psychiatry, American Psychiatric Association, Washington, D.C.

    Google Scholar 

  237. Wyatt, R. J., 1974, Am. J. Psychiatry 131:1258–1261.

    Google Scholar 

  238. Pauling, L., 1974, Am. J. Psychiatry 131:1251–1257.

    PubMed  CAS  Google Scholar 

  239. Herjanic, M., 1973, Orthomolecular Psychiatry: Treatment of Schizophrenia (D. Hawkins and L. Pauling, eds.), W. H. Freeman, San Francisco, pp. 303–315.

    Google Scholar 

  240. Milner, G., 1963, Br. J. Psychiatry 109:294–299.

    Article  Google Scholar 

  241. Kraepelin, E., 1910, Geschlachtliche Verirrungen und Volksvermehrungpsychiatric, edition 8, J. Barth, Leipzig.

    Google Scholar 

  242. Lewis, N. D. C., and Davies, G. R., 1921, J. Nerv. Ment. Dis. 54:385–493.

    Article  Google Scholar 

  243. Mott, F. W., 1922, Br. Med. J. 1:463–467.

    Article  PubMed  CAS  Google Scholar 

  244. Morse, M. E., 1923, J. Neurol. Psychopathol. 4:1–26.

    Article  PubMed  CAS  Google Scholar 

  245. Geller, F. C., 1923 Arch. Gynakol. 120:237–248.

    Article  Google Scholar 

  246. Rey, J. H., and Coppen, A. J., 1959, Br. Med. J. 11:1445–1447.

    Article  Google Scholar 

  247. Richter, D., 1970, Biol. Psychiatry 2:153–164.

    PubMed  CAS  Google Scholar 

  248. Hoskins, R. G., 1943, Psychosom. Med. 5:3–9.

    Google Scholar 

  249. Hemphill, R. E., and Reiss, M., 1945, J. Ment. Sci. 91:1–7.

    Google Scholar 

  250. Shader, R. I., Taymoor, M. I., and Grinspoon, L., 1968, Proceedings IV World Congress of Psychiatry, pp. 2988–2991.

    Google Scholar 

  251. Johnstone, E. C., Crow, T. J., and Mashiter, K., 1977, Psychol. Med. 7:223–228.

    Article  PubMed  CAS  Google Scholar 

  252. Ferrier, I. N., 1982, Biological Aspects of Schizophrenia and Addiction, (G. Hemmings, ed.), John Wiley and Sons, New York, pp. 35–47.

    Google Scholar 

  253. Horrobin, D. F., 1977, Lancet 1:936–937.

    Article  PubMed  CAS  Google Scholar 

  254. Feldberg, W., 1976, Psychol. Med. 6:359–369.

    Article  PubMed  CAS  Google Scholar 

  255. Price, E. J., and Rowe, C. E., 1972, Biochem. J. 126:575.

    PubMed  CAS  Google Scholar 

  256. Mathe, A. A., Sedvall, C., Wiesel, F. A., and Nyback, H., 1980, Lancet 1:16–17.

    Article  PubMed  CAS  Google Scholar 

  257. Wolfe, L. S., and Coceani, F., 1979, Annu. Rev. Physiol. 41:669–684.

    Article  PubMed  CAS  Google Scholar 

  258. Lycke, E., and Roos, B. E., 1968, Experientia 24:687–689.

    Article  PubMed  CAS  Google Scholar 

  259. Lycke, E., and Roos, B. E., 1974, J. Neurol. Sci. 22:277–289.

    Article  PubMed  CAS  Google Scholar 

  260. Rosenthal, D., Wender, P. H., Kety, S. S., Schulsinger, F., Welner, J., and Oskergaard, J., The Transmission of Schizophrenia (D. Rosenthal and S. S. Kety, eds.), Pergamon Press, New York.

    Google Scholar 

  261. Slater, E., 1968, The Transmission of Schizophrenia (D. Rosenthal and S. S. Kety eds.), Pergamon Press, New York.

    Google Scholar 

  262. Kety, S. S., Rosenthal, D., Wender, P. H., Schulsinger, F., and Jacobsen, B., 1975, Genetic Research in Psychiatry (R. R. Fieve, D. Rosenthal, and H. Brill, eds.), Johns Hopkins University Press, Baltimore.

    Google Scholar 

  263. Cancro, R., 1982, Psychiatry 1982: The American Psychiatric Association Annual Review (L. Grinspoon, ed.), American Psychiatric Press, Washington, pp. 92–96.

    Google Scholar 

  264. Gottesman, I. I., and Shields, J., 1976, Schizophren. Bull. 2:360–401.

    Article  CAS  Google Scholar 

  265. Lidz, T., Schafer, S., Fleck, S., Cornelison, A., and Terry, D., 1962, J. Am. Psychoanal. Assoc. 10:74–90.

    Article  PubMed  CAS  Google Scholar 

  266. Jackson, D. D., 1959, The Study of Schizophrenia (D. D. Jackson, ed.), Basic Books, New York, pp. 37–90.

    Google Scholar 

  267. Allen, M. G., Cohen, S., and Pollin, W., 1971, Am. J. Psychiatry 128:939–945.

    Google Scholar 

  268. Elston, R. C., and Cambell, M. A., 1970, Behav. Genet. 1:3–10.

    Article  PubMed  CAS  Google Scholar 

  269. Tsuang, M. T., Bucher, K. D., and Fleming, J. A., 1982, Br. J. Psychiatry 140:595–599.

    Article  PubMed  CAS  Google Scholar 

  270. DeLisi, L. E., Wise, C. D., Bridge, T. P., Potkin, S., Phelps, B., and Wyatt, R. J., 1981, Biological Markers for Mental Illness, Pergammon Press, New York, pp. 79–96.

    Google Scholar 

  271. Weinshilboum, R. M., Raymond, F. A., Elveback, L. R., and Weidman, W. H., 1973, Science 181:943.

    Article  PubMed  CAS  Google Scholar 

  272. Ross, S. B., Book, J. A., and Wetterberg, L., 1981, Clin. Genet. 19(5):415–426.

    Article  PubMed  CAS  Google Scholar 

  273. Fujita, D., Ito, T., Maruta, K., Teradaera, R., Beppu, H., Nakagama, Y., Kato, Y., Nagatsu, T., and Kato, T., 1978, J. Neurochem. 30:1569–1572.

    Article  PubMed  CAS  Google Scholar 

  274. Böök, J. A., Wetterberg, L., and Modrzewska, S., 1978, Clin. Genet. 14(6):373–394.

    Article  PubMed  Google Scholar 

  275. DeLisi, L. E., Wise, C. D., Phelps, B. H., Zalcman, S., Potkin, S. G., and Wyatt, R. J., 1980, Biol. Psychiatry 15(6):899–905.

    Google Scholar 

  276. Markianos, E. S., Nystrom, I., Reichel, H., and Matussek, N., 1976, Psychopharmacology 50:259–267.

    Article  PubMed  CAS  Google Scholar 

  277. Sternberg, D. E., van Kammen, D. P., Lerner, P., and Bunney, W. E., 1980 Abstracts of the Annual Meeting of the Society of Biological Psychiatry, San Francisco.

    Google Scholar 

  278. van Kammen, D. P., Mann, L., Sternberg, D. E., Scheinan, M., Ninan, P., Marder, S. R., van Kammen, W. B., Reider, R., and Linnoila, M., 1983, Science 220:974–977.

    Article  PubMed  Google Scholar 

  279. DeLisi, L. E., Phelps, B., Wise, C. D., Apostoles, P. S., and Wyatt, R. J., 1981, Biol. Psychiatry 16:873–878.

    PubMed  CAS  Google Scholar 

  280. Jeste, D. V., DeLisi, L. E., Zalcman, S., Wise, C. D., Phelps, B. H., Rosenblatt, J. E., Potkin, S. G., Bridge, T. P., and Wyatt, R. J., 1981, Psychiatry Res. 4:327–332.

    Article  PubMed  CAS  Google Scholar 

  281. Viukari, M., and Linnoila, M., 1977, Acta. Psychiatr. Scand. 56:57–61.

    Article  PubMed  CAS  Google Scholar 

  282. Birket-Smith, E., and Anderson, J. V., 1973, Lancet 1:431.

    Article  PubMed  CAS  Google Scholar 

  283. Menninger, K. A., 1925, Assoc. Res. Nerv. Ment. Dis. Proc. 5:182–203.

    Google Scholar 

  284. Petrov, P. A., 1970, Am. J. Trop. Med. Hyg. 19:146–150.

    PubMed  CAS  Google Scholar 

  285. Torrey, E. F., 1980, Civilization and Schizophrenia, Jason Aronson, New York.

    Google Scholar 

  286. Torrey, E. F., Torrey, B., and Peterson, M., 1977, Arch. Gen. Psychiatry 34:1065–1070.

    Article  PubMed  CAS  Google Scholar 

  287. Hare, E. H., and Walter, S. D., 1978, J. Epidemiol. Commun. Health 32:47–52.

    Article  CAS  Google Scholar 

  288. Abe, K., 1969, Br. J. Psychiatry 115:519–531.

    Article  PubMed  CAS  Google Scholar 

  289. Crow, T. J., 1983, Lancet 1:173–175.

    Article  PubMed  CAS  Google Scholar 

  290. Strahilevitz, M., Fleishman, J., Fischer, G., Harris, R., and Narasimhachari, N., 1976, Am. J. Psychiatry 133:.772–777.

    PubMed  CAS  Google Scholar 

  291. Torrey, E. F., Peterson, M. R., Brannon, W. L., Carpenter, W. T., Post, R. M., and van Kammen, D. P., 1978, Br. J. Psychiatry 132:342–348.

    Article  CAS  Google Scholar 

  292. Gowdy, J. M., 1980, Psycho somatic s 21:751–756.

    CAS  Google Scholar 

  293. DeLisi, L. E., Weinberger, D. R., Neckers, L. M., Potkin, S. G., Shiling, D., and Wyatt, R. J., 1981, Br. J. Psychiatry 139:513–519.

    Article  PubMed  CAS  Google Scholar 

  294. Amkraut, A., Solomon, G. F., Allansmith, M., McClellan, B., and Rappaport, M., 1973, Arch. Gen. Psychiatry 28:673–677.

    Article  PubMed  CAS  Google Scholar 

  295. Johnstone, E. C., and Whaley, K., 1975, Br. Med. J. 2:724–725.

    Article  PubMed  CAS  Google Scholar 

  296. Koliaskina, G., Tsutsulkovskaya, M., Domashneva, L, Maznina, T., Kielholz, P., Gastpar, M., Bunney, W., Rafaelson, O., Heltberg, J., Coppen, A., Hippius, H., Hoechesl, B., and Vartanian, F., 1980, Neuropsychobiology 6:349–355.

    Article  PubMed  CAS  Google Scholar 

  297. Watanabe, M., Funahashi, T., Suzuki, T., Nomura, S., Nakazawa, T., Noguchi, T., and Tsukada, Y., 1982, Biol. Psychiatry 17(6):699–710.

    PubMed  CAS  Google Scholar 

  298. Halonen, P., Rimon, R., Arochonka, R., and Jantti, V., 1974, Br. J. Psychiatry 125:461–465.

    Article  PubMed  CAS  Google Scholar 

  299. Rimon, R., Halonen, P., Pukakka, P., Laitinen, L., Marttila, R., and Salmela, L., 1979, J. Clin. Psychiatry 40:241–243.

    PubMed  CAS  Google Scholar 

  300. Albrecht, P., Torrey, E. F., Boone, E., Hicks, J., and Daniel, N., 1980, Lancet 2:769–772.

    Article  PubMed  CAS  Google Scholar 

  301. Torrey, E. F., Yolken, R. H., Winfrey, C. J., 1982, Science 216:892–894.

    Article  PubMed  CAS  Google Scholar 

  302. Tyrrell, D. A. J., Parry, R. P., Crow, T. J., Johnstone, E., and Ferrier, I. N., 1979, Lancet 1:839–841.

    Article  PubMed  CAS  Google Scholar 

  303. Taylor, G. R., Crow, T. J., Ferrier, I. N., Johnstone, E. C., Parry, R. P., and Tyrrell, D. A. J., 1982, Lancet 2:1166–1167.

    Article  PubMed  CAS  Google Scholar 

  304. Sequiera, L. W., Carrasco, L. H., Curry, A., Jennings, L. C., Lord, M. A., and Sutton, R. N. P., 1979, Lancet 2:609–612.

    Article  PubMed  CAS  Google Scholar 

  305. Johnson, R. T., 1982, Viral Infections of the Nervous System, Raven Press, New York.

    Google Scholar 

  306. Nyberg, P., Almay, B. G. L., Carlsson, A., Masters, C., and Winblad, B., 1982, Acta Neurol. Scand. 66:16–24.

    Article  PubMed  CAS  Google Scholar 

  307. Hughes, J. J., and Little, J. C., 1967, Br. J. Psychiatry 113:867–873.

    Article  PubMed  CAS  Google Scholar 

  308. Letemendia, F. J. J., and Harris, A. D., 1967, Br. J. Psychiatry 113:950–958.

    Article  PubMed  CAS  Google Scholar 

  309. Baker, H. F., Bloxham, C., Crow, T. J., Davies, H., Ferrier, I. N., Johnstone, E. C., Parry, R. P., Ridley, R. M., Taylor, G. R., Tyrrell, D. A. J., 1983, Adv. Biol. Psychiat. 12:1–19.

    Google Scholar 

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Authors and Affiliations

  1. Neurogenetics Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland, 20205, USA

    Lynn Eleanor DeLisi

  2. Neuropsychiatry Branch, Intramural Research Program, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C., 20032, USA

    Richard Jed Wyatt

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  1. Lynn Eleanor DeLisi
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  2. Richard Jed Wyatt
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  1. Center for Neurochemistry, Wards Island, New York, USA

    Abel Lajtha

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© 1985 Plenum Press, New York

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DeLisi, L.E., Wyatt, R.J. (1985). Neurochemical Aspects of Schizophrenia. In: Lajtha, A. (eds) Pathological Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0797-7_21

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  • DOI: https://doi.org/10.1007/978-1-4757-0797-7_21

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