Abstract
The application of crystallographic techniques to Fab, Fc, and light-chain components of immunoglobulins has provided a three-dimensional framework for interpreting chemical and biological observations like those summarized by Metzger in the next chapter (p. 119) (Poljak et al.,1974, 1976; Segal et al.,1974; Padian et al.,1974; Davies et al., 1975; Deisenhofer et al., 1976; Epp et al., 1974; Fehlhammer et al.,1975; Wang et al., 1975; Schiffer et al., 1973; Edmundson et al., 1975). These high-resolution analyses have been supplemented by low-resolution studies of intact IgG1 and IgG2 immunoglobulins (Sarma et al., 1971; Silverton et al.,1977; Colman et al., 1976; Edmundson et al.,1970; Ely et al.,1978a; Colman et al.,unpublished data). The structures of immunoglobulin components are well described in the above articles and they will not be discussed in detail in the present report. Instead, we shall concentrate on recent crystallographic work relating to the capacities of immunoglobulins to assume different conformations.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Amzel, L. M., Poljak, R. J., Saul, F., Varga, J. M., and Richards, F. F., 1974, Proc. Nat. Acad. Sci. USA 71: 1427.
Cathou, R. E., and Dorrington, K. J., 1975, in: Biological Macromolecules, Subunits in Biological Systems, Part C, Vol. 7 (G. D. Fasman, and S. N. Timasheff, eds.), p. 91, Marcel Dekker, New York.
Colman, P. M., Deisenhofer, J., Huber, R., and Palm, W., 1976, J. Mol. Biol. 100: 257.
Crowther, R. A., 1971, in: The Molecular Replacement Method (M. G. Rossmann, ed.), p. 173, Gordon and Breach, New York.
Davies, D. R., Padlan, E. A., and Segal, D. M.. 1975, Ann. Rev. Biochem. 44: 639.
Deisenhofer, J., Colman, P. M., Epp, O., and Huber, R. (1976), Hoppe-Seyler’s Z. Physiol. Chem. 357: 1421.
Edmundson, A. B., Wood, M. K., Schiffer, M., Hardman, K. D., Ainsworth, C. F., Ely, K. R., and Deutsch, H. F., 1970, J. Biol. Chem. 245: 2763.
Edmundson, A. B., Ely, K. R., Girling, R. L., Abola, E. E., Schiffer, M., Westholm, F. A., Fausch, M. D., and Deutsch, H. F., 1974, Biochemistry 13: 3816.
Edmundson, A. B., Ely, K. R., Abola, E. E., Schiffer, M., and Panagiotopoulos, N., 1975, Biochemistry 14: 3953.
Ely, K. R., Colman, P. M., Abola, E. E., Hess, A. C., Peabody, D. S., Parr, D. M., Connell, G. E., Laschinger, C. A., and Edmundson, A. B., 1978a, Biochemistry 17: 820.
Ely, K. R., Firca, J. R., Williams, K. J., Abola, E. E., Fenton, J. M., Schiffer, M., Panagiotopoulos, N. C., and Edmundson, A. B., 1978b, Biochemistry 17: 158.
Epp, O., Colman, P., Fehlhammer, H., Bode, W., Schiffer, M., Huber, R., and Palm, W., 1974, Eur. J. Biochem. 45: 513.
Fehlhammer, H., Schiffer, M., Epp, O., Colman, P. M., Lattman, E. E., Schwager, P., Steigemann, W., and Schramm, H. J., 1975, Biophys. Struct. Mechanism 1: 139.
Feinstein, A., 1975, in: The Immune System, Vol. I (M. Hobart and I. McConnell, eds.), p. 24, Oxford, Blackwell.
Fett, J. W., Deutsch, H. F., and Smithies, O., 1973, Immunochemistry 10: 115.
Firca, J. R., Ely, K. R., Kremser, P., Westholm, F. A., Dorrington, K. J., and Edmundson, A. B., 1978, Biochemistry 17: 148.
Green, N. M., 1969, Adv. Immunol. II: 1.
Huber, R., Deisenhofer, J., Colman, P. M., Matsushima, M., and Palm, W., 1976, Nature (London) 264: 415.
Lataw, L. W., and Davies, D. R., 1971, J. Biol. Chem. 247: 3760.
Lancet, D., Licht, A., Schechter, I., and Pecht, I., 1977, Nature (London) 269: 827.
Lopes, A. D., and Steiner, L. A., 1973, Fed. Proc. 32: 1003.
Milstein, C., and Pink, J. R. L., 1970, Progr. Biophys. Mol. Biol. 21: 209.
Noelken, M. E., Nelson, C. A., Buckley, C. E., III, and Tanford, C., 1965, J. Biol. Chem. 240: 218.
Padlan, E. A., Segal, D. M., Cohen, G. H., Davies, D. R., Rudikoff, S., and Potter, M., 1974, in: The Immune System (E. E. Sercarz, A. R. Williamson, and C. F. Cox, eds.), p. 7. Academic Press, New York.
Padlan, E. A., Davies, D. R., Rudikoff, S., and Potter, M., 1976, Immunochemistry 13: 945.
Panagiotopoulos, N. C., Abola, E. E., Ely, K. R., Schiffer, M., and Edmundson, A. B., 1977, Am. Cryst. Assoc. Meeting, Asilomar, EA 1, p. 16.
Poljak, R. J., Amzel, L. M., Chen, B. L., Phizackerley, R. P., and Saul, F., 1974, Proc. Nat. Acad. Sci. USA 71: 3440.
Poljak, R. J., Amzel, L. M., and Phizackerley, R. P., 1976, Progr. Biophys. Mol. Biol. 31: 67.
Rossmann, M. G., and Blow, D. M., 1962, Acta Cryst. 15: 24.
Sauna, V. R., Silverton, E. W., Davies, D. R., and Terry, W. D., 1971, J. Biol. Chem. 247: 3753.
Schechter, I., Ziv, E., and Licht, A., 1976, Biochemistry 15: 2785.
Schiffer, M., Girling, R. L., Ely, K. R., and Edmundson, A. B., 1973, Biochemistry 12: 4620.
Segal, D. M., Padlan, E. A., Cohen, G. H., Rudikoff, S., Potter, M., and Davies, D. R., 1974, Proc. Nat. Acad. Sci. USA 71: 4298.
Silverton, E. W., Navia, M. A., and Davies, D. R., 1977, Proc. Nat. Acad. Sci. USA, 74: 5140.
Wang, B.-C., Yoo, C. S., and Sax, M., 1975, Am. Cryst. Assoc. Meeting, Charlottesville, A 4.
Zaloga, G., and Sarnia, V. R., 1974, Nature (London) 251: 551.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Springer Science+Business Media New York
About this chapter
Cite this chapter
Edmundson, A.B., Ely, K.R., Abola, E.E. (1978). Conformational Flexibility in Immunoglobulins. In: Reisfeld, R.A., Inman, F.P. (eds) Contemporary Topics in Molecular Immunology. Contemporary Topics in Molecular Immunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0779-3_3
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0779-3_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0781-6
Online ISBN: 978-1-4757-0779-3
eBook Packages: Springer Book Archive