Summary
Human sera, exceptionally, do contain lymphocytotoxic antibodies which detect polymorphic mouse lymphocyte membrane antigens whose expression is controled by the H-2 complex. In accordance with the original plans of Gorer, mouse transplantation antigens, namely the H-2 system, might have been discovered by naturally occurring human antibodies.
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References
Gorer, P.A.: The detection of a hereditary antigenic difference in the blood of mice by means of human group A serum. J. Genetics, 32: 17–31, 1936.
Ivanyi, P., Leupers, T., Mourik, P. van,: Naturally occurring cytotoxic human antibodies recognize H-2 controlled murine lymphocytotoxic antigens. Proc.Ndt.ANad.Soti.USA, 80: 4479–4483, 1983.
Klein, J.: Natural History of the Major Histocompatibility Complex. J. Wiley and Sons New York, 198, 1968.
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© 1987 Springer Science+Business Media New York
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Ivanyi, P., Kloosterman, T. (1987). Peter Gorer Could Discover the H-2 Complex by Naturally Occurring Human Antibodies. In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_2
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DOI: https://doi.org/10.1007/978-1-4757-0764-9_2
Publisher Name: Springer, Boston, MA
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